MicroRNA-181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) exhibit extensive self‐renewal potential and can modulate immunocyte activation. Our previous study reported that miR‐181a expression was significantly increased in placenta from women with severe preeclampsia (PE), but the mechanisms by which miR‐181a regulates MSCs ar...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2012-08, Vol.30 (8), p.1756-1770
Hauptverfasser:	Liu, Liu, Wang, Yaping, Fan, Hongye, Zhao, Xiaoyin, Liu, Dan, Hu, Yali, Kidd III, Ambrose R., Bao, Jianxin, Hou, Yayi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Cell Growth Processes - immunology Disease Models, Animal Humans IL-6 Interleukin-6 - immunology MAPK Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - immunology Mice MicroRNAs - genetics MicroRNAs - immunology miR-181a Stem cells TGF-β Transfection Transforming Growth Factor beta - immunology
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