miR-34a Expression, Cell Cycle Arrest and Cell Death of Malignant Mesothelioma Cells upon Treatment with Radiation, Docetaxel or Combination Treatment

Objective: Malignant mesothelioma (MM) is a highly aggressive tumour related to asbestos exposure. Histopathologically, the tumour is classified as epithelial, sarcomatoid or biphasic. To date, MM is still an incurable disease. Methods: To evaluate treatment strategies on MM cells, the effects of ra...

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Veröffentlicht in:	Oncology 2011-01, Vol.81 (5-6), p.330-335
Hauptverfasser:	Ghawanmeh, Taha, Thunberg, Ulf, Castro, Juan, Murray, Fiona, Laytragoon-Lewin, Nongnit
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Asbestos Biological and medical sciences Cell cycle Cell Cycle - drug effects Cell Cycle - genetics Cell Cycle - radiation effects Cell Cycle Checkpoints - drug effects Cell Cycle Checkpoints - genetics Cell Cycle Checkpoints - radiation effects Cell death Cell Death - drug effects Cell Death - genetics Cell Death - radiation effects Cell Line, Tumor Cell number Clinical Translational Research Combined Modality Therapy - methods Docetaxel Humans Lung diseases Malignant mesothelioma Medical sciences mesothelioma Mesothelioma - drug therapy Mesothelioma - genetics Mesothelioma - pathology Mesothelioma - radiotherapy MicroRNAs - biosynthesis MicroRNAs - genetics Microtubules miR-34a Oncology p53 p53 protein Radiation Radiation therapy Radiation-Sensitizing Agents - pharmacology Radiotherapy Taxoids - pharmacology Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Tumors
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