Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: Pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors

Serotonin (5-HT) exerts multiple physiological functions not only in the central and peripheral nervous systems but also in the gastrointestinal tract, and these multiple functions are accounted for by a variety of 5-HT receptor subtypes. We investigated the role of 5-HT in the pathogenesis of indom...

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Veröffentlicht in:	Pharmacological research 2012-09, Vol.66 (3), p.226-234
Hauptverfasser:	Kato, Shinichi, Matsuda, Narumi, Matsumoto, Kenjiro, Wada, Mai, Onimaru, Naoki, Yasuda, Masashi, Amagase, Kikuko, Horie, Syunji, Takeuchi, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT receptor subtyeps Aconitine - analogs & derivatives Aconitine - pharmacology alpha7 Nicotinic Acetylcholine Receptor Animals Anti-Ulcer Agents - pharmacology Benzamides - pharmacology Dual role of serotonin Fenclonine - pharmacology Indoles - pharmacology Indomethacin Indomethacin-induced intestinal lesions Intestinal Diseases - chemically induced Intestinal Diseases - drug therapy Intestinal Diseases - metabolism Intestinal Diseases - pathology Intestine, Small - drug effects Intestine, Small - metabolism Intestine, Small - pathology Male Mice Mice, Inbred C57BL Morpholines - pharmacology Mosapride Ondansetron Ondansetron - pharmacology Receptors, Nicotinic - metabolism Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT3 - metabolism Receptors, Serotonin, 5-HT4 - metabolism Serotonin - metabolism Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Sulfonamides - pharmacology Ulcer - chemically induced Ulcer - drug therapy Ulcer - metabolism Ulcer - pathology
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