Triple Receptor―Negative Breast Cancer: Imaging and Clinical Characteristics
The objective of our study was to retrospectively evaluate the imaging findings of patients with breast cancer negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)-so-called "triple receptor-negative cancer"-and to compare the...
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| Veröffentlicht in: | American journal of roentgenology (1976) 2012-08, Vol.199 (2), p.458-464 |
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| container_title | American journal of roentgenology (1976) |
| container_volume | 199 |
| creator | KRIZMANICH-CONNIFF, Kristin M PARAMAGUL, Chintana PATTERSON, Stephanie K HELVIE, Mark A ROUBIDOUX, Marilyn A MYLES, Jamie D JIANG, Kiting SABEL, Michael |
| description | The objective of our study was to retrospectively evaluate the imaging findings of patients with breast cancer negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)-so-called "triple receptor-negative cancer"-and to compare the mammographic findings and clinical characteristics of triple receptor-negative cancer with non-triple receptor-negative cancers (i.e., ER-positive, PR-positive, or HER2-positive or two of the three markers positive).
Triple receptor-negative cancer was most commonly an irregular noncalcified mass with ill-defined or spiculated margins on mammography and a hypoechoic or complex mass with an irregular shape and noncircumscribed margins on ultrasound. Most triple receptor-negative cancers were discovered on physical examination. Compared with non-triple receptor-negative cancers, triple receptor-negative cancers were found in younger women and were a higher pathologic grade. |
| doi_str_mv | 10.2214/AJR.10.6096 |
| format | Article |
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Triple receptor-negative cancer was most commonly an irregular noncalcified mass with ill-defined or spiculated margins on mammography and a hypoechoic or complex mass with an irregular shape and noncircumscribed margins on ultrasound. Most triple receptor-negative cancers were discovered on physical examination. Compared with non-triple receptor-negative cancers, triple receptor-negative cancers were found in younger women and were a higher pathologic grade.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/AJR.10.6096</identifier><identifier>PMID: 22826413</identifier><identifier>CODEN: AAJRDX</identifier><language>eng</language><publisher>Reston, VA: American Roentgen Ray Society</publisher><subject>Adult ; Biological and medical sciences ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Chi-Square Distribution ; Female ; Genital system. Mammary gland ; Gynecology. Andrology. Obstetrics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Logistic Models ; Mammary gland diseases ; Mammography ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Registries ; Retrospective Studies ; Risk Factors ; Statistics, Nonparametric ; Tumors ; Ultrasonography, Mammary</subject><ispartof>American journal of roentgenology (1976), 2012-08, Vol.199 (2), p.458-464</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-905aca560b4d3900c94938af5d9c1900a6ccab9bff7800b08743ac9f700765b53</citedby><cites>FETCH-LOGICAL-c356t-905aca560b4d3900c94938af5d9c1900a6ccab9bff7800b08743ac9f700765b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4106,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26181155$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22826413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KRIZMANICH-CONNIFF, Kristin M</creatorcontrib><creatorcontrib>PARAMAGUL, Chintana</creatorcontrib><creatorcontrib>PATTERSON, Stephanie K</creatorcontrib><creatorcontrib>HELVIE, Mark A</creatorcontrib><creatorcontrib>ROUBIDOUX, Marilyn A</creatorcontrib><creatorcontrib>MYLES, Jamie D</creatorcontrib><creatorcontrib>JIANG, Kiting</creatorcontrib><creatorcontrib>SABEL, Michael</creatorcontrib><title>Triple Receptor―Negative Breast Cancer: Imaging and Clinical Characteristics</title><title>American journal of roentgenology (1976)</title><addtitle>AJR Am J Roentgenol</addtitle><description>The objective of our study was to retrospectively evaluate the imaging findings of patients with breast cancer negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)-so-called "triple receptor-negative cancer"-and to compare the mammographic findings and clinical characteristics of triple receptor-negative cancer with non-triple receptor-negative cancers (i.e., ER-positive, PR-positive, or HER2-positive or two of the three markers positive).
Triple receptor-negative cancer was most commonly an irregular noncalcified mass with ill-defined or spiculated margins on mammography and a hypoechoic or complex mass with an irregular shape and noncircumscribed margins on ultrasound. Most triple receptor-negative cancers were discovered on physical examination. Compared with non-triple receptor-negative cancers, triple receptor-negative cancers were found in younger women and were a higher pathologic grade.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Genital system. Mammary gland</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Logistic Models</subject><subject>Mammary gland diseases</subject><subject>Mammography</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Statistics, Nonparametric</subject><subject>Tumors</subject><subject>Ultrasonography, Mammary</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0N1KwzAUwPEgipvTK--lN4IgnUnTpIl3s_jJmDAmeFdO03RG-mXSCd75Er6gT2LGpl7lBH4cOH-EjgkeRxGJLyYP87GfOZZ8Bw0Ji3lISUx20RBTTkKB6fMAHTj3ijFOhEz20SCKRMRjQodotrCmq3Qw10p3fWu_P79megm9edfBldXg-iCFRml7GdzXsDTNMoCmCNLKNEZBFaQvYEH12hrXG-UO0V4JldNH23eEnm6uF-ldOH28vU8n01BRxvtQYgYKGMd5XFCJsZKxpAJKVkhF_B-4UpDLvCwTgXGORRJTULJM_AWc5YyO0Nlmb2fbt5V2fVYbp3RVQaPblcsIjhJBqUwiT883VNnWOavLrLOmBvvhUbYOmPmA63kd0OuT7eJVXuviz_4W8-B0C8D5AKX1dYz7d5wIQhijP2nqeA8</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>KRIZMANICH-CONNIFF, Kristin M</creator><creator>PARAMAGUL, Chintana</creator><creator>PATTERSON, Stephanie K</creator><creator>HELVIE, Mark A</creator><creator>ROUBIDOUX, Marilyn A</creator><creator>MYLES, Jamie D</creator><creator>JIANG, Kiting</creator><creator>SABEL, Michael</creator><general>American Roentgen Ray Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Triple Receptor―Negative Breast Cancer: Imaging and Clinical Characteristics</title><author>KRIZMANICH-CONNIFF, Kristin M ; PARAMAGUL, Chintana ; PATTERSON, Stephanie K ; HELVIE, Mark A ; ROUBIDOUX, Marilyn A ; MYLES, Jamie D ; JIANG, Kiting ; SABEL, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-905aca560b4d3900c94938af5d9c1900a6ccab9bff7800b08743ac9f700765b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Genital system. Mammary gland</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Logistic Models</topic><topic>Mammary gland diseases</topic><topic>Mammography</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Statistics, Nonparametric</topic><topic>Tumors</topic><topic>Ultrasonography, Mammary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KRIZMANICH-CONNIFF, Kristin M</creatorcontrib><creatorcontrib>PARAMAGUL, Chintana</creatorcontrib><creatorcontrib>PATTERSON, Stephanie K</creatorcontrib><creatorcontrib>HELVIE, Mark A</creatorcontrib><creatorcontrib>ROUBIDOUX, Marilyn A</creatorcontrib><creatorcontrib>MYLES, Jamie D</creatorcontrib><creatorcontrib>JIANG, Kiting</creatorcontrib><creatorcontrib>SABEL, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of roentgenology (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KRIZMANICH-CONNIFF, Kristin M</au><au>PARAMAGUL, Chintana</au><au>PATTERSON, Stephanie K</au><au>HELVIE, Mark A</au><au>ROUBIDOUX, Marilyn A</au><au>MYLES, Jamie D</au><au>JIANG, Kiting</au><au>SABEL, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triple Receptor―Negative Breast Cancer: Imaging and Clinical Characteristics</atitle><jtitle>American journal of roentgenology (1976)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>199</volume><issue>2</issue><spage>458</spage><epage>464</epage><pages>458-464</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><coden>AAJRDX</coden><abstract>The objective of our study was to retrospectively evaluate the imaging findings of patients with breast cancer negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)-so-called "triple receptor-negative cancer"-and to compare the mammographic findings and clinical characteristics of triple receptor-negative cancer with non-triple receptor-negative cancers (i.e., ER-positive, PR-positive, or HER2-positive or two of the three markers positive).
Triple receptor-negative cancer was most commonly an irregular noncalcified mass with ill-defined or spiculated margins on mammography and a hypoechoic or complex mass with an irregular shape and noncircumscribed margins on ultrasound. Most triple receptor-negative cancers were discovered on physical examination. Compared with non-triple receptor-negative cancers, triple receptor-negative cancers were found in younger women and were a higher pathologic grade.</abstract><cop>Reston, VA</cop><pub>American Roentgen Ray Society</pub><pmid>22826413</pmid><doi>10.2214/AJR.10.6096</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of roentgenology (1976), 2012-08, Vol.199 (2), p.458-464 |
| issn | 0361-803X 1546-3141 |
| language | eng |
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| source | American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Chi-Square Distribution Female Genital system. Mammary gland Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Logistic Models Mammary gland diseases Mammography Medical sciences Middle Aged Neoplasm Invasiveness Radiodiagnosis. Nmr imagery. Nmr spectrometry Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Registries Retrospective Studies Risk Factors Statistics, Nonparametric Tumors Ultrasonography, Mammary |
| title | Triple Receptor―Negative Breast Cancer: Imaging and Clinical Characteristics |
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