Improving intraperitoneal chemotherapeutic effect and preventing postsurgical adhesions simultaneously with biodegradable micelles

Abstract The two major concerns after cytoreductive surgery of abdominal and pelvic malignancies are residual tumors and peritoneal adhesions, which are inevitable and have great impact on prognosis. Therefore, to improve the intraperitoneal chemotherapeutic effect and prevent postsurgical adhesions...

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Veröffentlicht in:	Nanomedicine 2012-08, Vol.8 (6), p.963-973
Hauptverfasser:	Gong, ChangYang, PhD, Yang, Bing, MD, Qian, ZhiYong, PhD, Zhao, Xia, MD, Wu, QinJie, PhD, Qi, XiaoRong, MD, Wang, YuJun, PhD, Guo, Gang, PhD, Kan, Bing, PhD, Luo, Feng, MD, Wei, YuQuan, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Animals Antiadhesion barrier Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Cell Line, Tumor Combined Modality Therapy Doxorubicin - administration & dosage Doxorubicin - chemistry Drug delivery system Drug Synergism Female Internal Medicine Intraperitoneal chemotherapy Mice Mice, Inbred BALB C Micelles Nanocapsules - administration & dosage Nanocapsules - chemistry Peritoneal Neoplasms - complications Peritoneal Neoplasms - therapy Postsurgical adhesion Tissue Adhesions - etiology Tissue Adhesions - prevention & control Treatment Outcome
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