Toxoplasmic cyst and heart transplant: a case report of serological reactivation in an acute graft rejection context
We describe the case of a serological reactivation in a Toxoplasma-seropositive subject, following a cardiac transplantation transmitting cysts contained in the myocardial tissue. In a context of acute graft rejection, primary chemoprophylaxis enables to avoid onset of opportunistic toxoplasmosis, e...
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| Veröffentlicht in: | Annales de biologie clinique (Paris) 2012-05, Vol.70 (3), p.323-328 |
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| container_end_page | 328 |
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| container_issue | 3 |
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| container_title | Annales de biologie clinique (Paris) |
| container_volume | 70 |
| creator | Desoubeaux, Guillaume Perret-Gallix, Kévin Machet, Marie-Christine Sirinelli, Agnès Bailly, Eric Van Langendonck, Nathalie Chandenier, Jacques |
| description | We describe the case of a serological reactivation in a Toxoplasma-seropositive subject, following a cardiac transplantation transmitting cysts contained in the myocardial tissue. In a context of acute graft rejection, primary chemoprophylaxis enables to avoid onset of opportunistic toxoplasmosis, emerging with immunodepletion performed by high-dose steroids. Then, we draw up a brief review of the bibliographical literature about pathophysiological mechanisms of toxoplasmic reactivation in heart transplants. |
| doi_str_mv | 10.1684/abc.2012.0706 |
| format | Article |
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In a context of acute graft rejection, primary chemoprophylaxis enables to avoid onset of opportunistic toxoplasmosis, emerging with immunodepletion performed by high-dose steroids. Then, we draw up a brief review of the bibliographical literature about pathophysiological mechanisms of toxoplasmic reactivation in heart transplants.</description><identifier>ISSN: 0003-3898</identifier><identifier>DOI: 10.1684/abc.2012.0706</identifier><identifier>PMID: 22565180</identifier><language>fre</language><publisher>France</publisher><subject>Acute Disease ; Antibodies, Protozoan - blood ; Antibodies, Protozoan - immunology ; Graft Rejection - etiology ; Graft Rejection - immunology ; Graft Rejection - parasitology ; Heart Transplantation - adverse effects ; Heart Transplantation - immunology ; Heart Transplantation - physiology ; Humans ; Lymphocyte Activation - immunology ; Lymphocyte Activation - physiology ; Male ; Middle Aged ; Serology ; Tissue Donors ; Toxoplasma - immunology ; Toxoplasma - isolation & purification ; Toxoplasma - physiology ; Toxoplasmosis - blood ; Toxoplasmosis - diagnosis ; Toxoplasmosis - etiology ; Toxoplasmosis - immunology</subject><ispartof>Annales de biologie clinique (Paris), 2012-05, Vol.70 (3), p.323-328</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22565180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Desoubeaux, Guillaume</creatorcontrib><creatorcontrib>Perret-Gallix, Kévin</creatorcontrib><creatorcontrib>Machet, Marie-Christine</creatorcontrib><creatorcontrib>Sirinelli, Agnès</creatorcontrib><creatorcontrib>Bailly, Eric</creatorcontrib><creatorcontrib>Van Langendonck, Nathalie</creatorcontrib><creatorcontrib>Chandenier, Jacques</creatorcontrib><title>Toxoplasmic cyst and heart transplant: a case report of serological reactivation in an acute graft rejection context</title><title>Annales de biologie clinique (Paris)</title><addtitle>Ann Biol Clin (Paris)</addtitle><description>We describe the case of a serological reactivation in a Toxoplasma-seropositive subject, following a cardiac transplantation transmitting cysts contained in the myocardial tissue. In a context of acute graft rejection, primary chemoprophylaxis enables to avoid onset of opportunistic toxoplasmosis, emerging with immunodepletion performed by high-dose steroids. 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| ispartof | Annales de biologie clinique (Paris), 2012-05, Vol.70 (3), p.323-328 |
| issn | 0003-3898 |
| language | fre |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acute Disease Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Graft Rejection - etiology Graft Rejection - immunology Graft Rejection - parasitology Heart Transplantation - adverse effects Heart Transplantation - immunology Heart Transplantation - physiology Humans Lymphocyte Activation - immunology Lymphocyte Activation - physiology Male Middle Aged Serology Tissue Donors Toxoplasma - immunology Toxoplasma - isolation & purification Toxoplasma - physiology Toxoplasmosis - blood Toxoplasmosis - diagnosis Toxoplasmosis - etiology Toxoplasmosis - immunology |
| title | Toxoplasmic cyst and heart transplant: a case report of serological reactivation in an acute graft rejection context |
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