Expression of activated type I receptor tyrosine kinases in early breast cancer

Overexpression of EGFR, HER2 and HER3 are known to be associated with poor outcome in breast cancer. Few studies have examined the clinical impact of activation of these proteins. In the present study, we evaluated EGFR, HER2 and HER3 and the activated (phosphorylated) forms of these proteins in pat...

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Veröffentlicht in:	Breast cancer research and treatment 2012-07, Vol.134 (2), p.701-708
Hauptverfasser:	Spears, Melanie, Pederson, Hans Christian, Lyttle, Nicola, Gray, Claire, Quintayo, Mary Anne, Brogan, Lyndsay, J Thomas, Jeremy St, Kerr, Gillian R., Jack, Wilma J. L., Kunkler, Ian H., Cameron, David A., Chetty, Udi, Bartlett, John M. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Cancer research Cancer therapies Care and treatment Clinical Trial Cohort Studies Disease-Free Survival Enzyme Activation Epidermal growth factor Female Gynecology. Andrology. Obstetrics Humans Kaplan-Meier Estimate Mammary gland diseases Medical prognosis Medical sciences Medicine Medicine & Public Health Middle Aged Oncology Phenols Phosphorylation Phosphotransferases Protein Processing, Post-Translational Proteins Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - metabolism Receptors, Estrogen - metabolism Tamoxifen - therapeutic use Tissue Array Analysis Tumors Tyrosine
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