Calorie Restriction from a Young Age Preserves the Functions of Pancreatic β Cells in Aging Rats

Calorie restriction (CR) is a simple method for delaying aging process, extending lifespan, and preventing the onset of aging-related diseases, such as diabetes. However, the mechanism, by which CR influences β-cell functions during the aging process, still remains unclear. In this study, sixteen 8-...

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Veröffentlicht in:	The Tohoku Journal of Experimental Medicine 2012, Vol.227(4), pp.245-252
Hauptverfasser:	He, Xiao-ye, Zhao, Xiao-long, Gu, Qian, Shen, Ji-ping, Hu, Yu, Hu, Ren-ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Apoptosis Blood Glucose - metabolism Body Weight Caloric Restriction calorie restriction Catalase - blood Cell Proliferation Energy Intake Glucose Tolerance Test Glutathione Peroxidase - blood In Situ Nick-End Labeling Insulin - blood Insulin-Secreting Cells - cytology Insulin-Secreting Cells - enzymology Insulin-Secreting Cells - physiology Intra-Abdominal Fat - metabolism Male Malondialdehyde - blood Organ Size oxidative stress pancreatic β-cell function pancreatic β-cell mass Proliferating Cell Nuclear Antigen - metabolism rat Rats Rats, Sprague-Dawley Superoxide Dismutase - blood Tissue Extracts
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