Orthosteric versus allosteric GPCR activation: The great challenge of group-III mGluRs

Group-III metabotropic glutamate receptors (mGluRs) comprise four structurally related brain and retinal G protein-coupled receptors (GPCRs), mGluR4, mGluR6, mGluR7 and mGluR8, which receive much attention as promising targets for nervous system drugs. In particular, activation of mGluR4 is a major...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 2012-08, Vol.84 (4), p.414-424
Hauptverfasser:	Flor, Peter J., Acher, Francine C.
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Allosteric Regulation AMN082 Animals brain Central Nervous System Agents - chemistry Central Nervous System Agents - pharmacology chemotypes drugs glutamic acid GPCR Humans LSP1-2111 LSP4-2022 Metabotropic glutamate Parkinson disease PHCCC receptors Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - metabolism screening therapeutics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!