Prognosis by C-reactive protein and matrix metalloproteinase-9 levels in stable coronary heart disease during 15 years of follow-up
Abstract Background and Aim Elevated CRP and matrix metalloproteinase-9 associate with increased risk of cardiovascular events, possibly because these plasma proteins mark vulnerable atherosclerotic plaques. We tested the hypothesis that levels of C-reactive protein (CRP) and matrix metalloproteinas...
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| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2012-08, Vol.22 (8), p.677-683 |
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| creator | Eldrup, N Kragelund, C Steffensen, R Nordestgaard, B.G |
| description | Abstract Background and Aim Elevated CRP and matrix metalloproteinase-9 associate with increased risk of cardiovascular events, possibly because these plasma proteins mark vulnerable atherosclerotic plaques. We tested the hypothesis that levels of C-reactive protein (CRP) and matrix metalloproteinase-9 associate with prognosis in patients with stable coronary heart disease. Methods and Results We measured baseline plasma CRP and matrix metalloproteinase-9 in 1090 patients with stable coronary heart disease and as the primary composite endpoint detected incident unstable angina, myocardial infarction and any death during 15 years of follow-up. CRP above versus below the median of 3.0 mg/L was associated with an increased cumulative incidence of unstable angina, myocardial infarction and any death combined (log-rank p |
| doi_str_mv | 10.1016/j.numecd.2010.11.003 |
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We tested the hypothesis that levels of C-reactive protein (CRP) and matrix metalloproteinase-9 associate with prognosis in patients with stable coronary heart disease. Methods and Results We measured baseline plasma CRP and matrix metalloproteinase-9 in 1090 patients with stable coronary heart disease and as the primary composite endpoint detected incident unstable angina, myocardial infarction and any death during 15 years of follow-up. CRP above versus below the median of 3.0 mg/L was associated with an increased cumulative incidence of unstable angina, myocardial infarction and any death combined (log-rank p < 0.0001). CRP above versus below the median had a corresponding hazard ratio of 1.5(95% CI, 1.3–1.8) after age adjustment, of 1.4(1.2–1.6) after multifactorial adjustment, and of 1.4(1.2–1.6) after multifactorial adjustment including degree of coronary disease. In contrast, matrix metalloproteinase-9 above versus below the median was not associated with risk of unstable angina, myocardial infarction and death. Conclusions Elevated CRP, but not elevated matrix metalloproteinase-9, associates with increased risk of unstable angina, myocardial infarction and death in patients with stable coronary heart disease.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2010.11.003</identifier><identifier>PMID: 21194909</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Angina, Unstable - mortality ; Biomarkers - blood ; C-reactive protein ; C-Reactive Protein - analysis ; Cardiovascular ; Cause of Death ; Chi-Square Distribution ; coronary disease ; Coronary Disease - blood ; Coronary Disease - enzymology ; Coronary Disease - immunology ; Coronary Disease - mortality ; Coronary heart disease ; death ; Denmark - epidemiology ; Disease Progression ; Female ; Follow-Up Studies ; gelatinase B ; Humans ; Kaplan-Meier Estimate ; Male ; Matrix Metalloproteinase 9 - blood ; Matrix metalloproteinase-9 ; Middle Aged ; myocardial infarction ; Myocardial Infarction - mortality ; patients ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; risk ; Risk Assessment ; Risk Factors ; Time Factors ; Up-Regulation</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2012-08, Vol.22 (8), p.677-683</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-207852f637423c85cce6d3e95bca234db8941b7c90c8790cd1f23aa65a38fe783</citedby><cites>FETCH-LOGICAL-c441t-207852f637423c85cce6d3e95bca234db8941b7c90c8790cd1f23aa65a38fe783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475310002693$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21194909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eldrup, N</creatorcontrib><creatorcontrib>Kragelund, C</creatorcontrib><creatorcontrib>Steffensen, R</creatorcontrib><creatorcontrib>Nordestgaard, B.G</creatorcontrib><title>Prognosis by C-reactive protein and matrix metalloproteinase-9 levels in stable coronary heart disease during 15 years of follow-up</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and Aim Elevated CRP and matrix metalloproteinase-9 associate with increased risk of cardiovascular events, possibly because these plasma proteins mark vulnerable atherosclerotic plaques. We tested the hypothesis that levels of C-reactive protein (CRP) and matrix metalloproteinase-9 associate with prognosis in patients with stable coronary heart disease. Methods and Results We measured baseline plasma CRP and matrix metalloproteinase-9 in 1090 patients with stable coronary heart disease and as the primary composite endpoint detected incident unstable angina, myocardial infarction and any death during 15 years of follow-up. CRP above versus below the median of 3.0 mg/L was associated with an increased cumulative incidence of unstable angina, myocardial infarction and any death combined (log-rank p < 0.0001). CRP above versus below the median had a corresponding hazard ratio of 1.5(95% CI, 1.3–1.8) after age adjustment, of 1.4(1.2–1.6) after multifactorial adjustment, and of 1.4(1.2–1.6) after multifactorial adjustment including degree of coronary disease. In contrast, matrix metalloproteinase-9 above versus below the median was not associated with risk of unstable angina, myocardial infarction and death. Conclusions Elevated CRP, but not elevated matrix metalloproteinase-9, associates with increased risk of unstable angina, myocardial infarction and death in patients with stable coronary heart disease.</description><subject>Aged</subject><subject>Angina, Unstable - mortality</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular</subject><subject>Cause of Death</subject><subject>Chi-Square Distribution</subject><subject>coronary disease</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - enzymology</subject><subject>Coronary Disease - immunology</subject><subject>Coronary Disease - mortality</subject><subject>Coronary heart disease</subject><subject>death</subject><subject>Denmark - epidemiology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>gelatinase B</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Matrix metalloproteinase-9</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - mortality</subject><subject>patients</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>risk</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuP0zAQgC0EYsvCP0DgI5cUP5I4viChanlIK4G07Nly7ElxcexiJ4We-eM4SuHAhYstjb8Zz3wahJ5TsqWEtq8P2zCPYOyWkSVEt4TwB2hDG0kqLph8iDZEclnVouFX6EnOhwIIwuvH6IpRKmtJ5Ab9-pziPsTsMu7PeFcl0GZyJ8DHFCdwAetg8ain5H7iESbtfby86AyVxB5O4DMuYJ507wGbmGLQ6Yy_gk4Tti5DIbGdkwt7TBt8LvGM44CHWIr9qObjU_Ro0D7Ds8t9je7f3XzZfahuP73_uHt7W5m6plPFiOgaNrRc1IybrjEGWstBNr3RjNe272RNe2EkMZ0oh6UD41q3jebdAKLj1-jVWrdM8H2GPKnRZQPe6wBxzooSJtqOsoYWtF5Rk2LOCQZ1TG4sYxVILfrVQa361aJfUaqK3ZL24vLD3I9g_yb98V2Alysw6Kj0Prms7u9KhYYQ0lFBSSHerETRCicHSWXjIBiwLoGZlI3ufz38W8B4F5zR_hucIR_inEKxrKjKTBF1tyzJsiO0tMBayflv4I23cQ</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Eldrup, N</creator><creator>Kragelund, C</creator><creator>Steffensen, R</creator><creator>Nordestgaard, B.G</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Prognosis by C-reactive protein and matrix metalloproteinase-9 levels in stable coronary heart disease during 15 years of follow-up</title><author>Eldrup, N ; Kragelund, C ; Steffensen, R ; Nordestgaard, B.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-207852f637423c85cce6d3e95bca234db8941b7c90c8790cd1f23aa65a38fe783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Angina, Unstable - mortality</topic><topic>Biomarkers - blood</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular</topic><topic>Cause of Death</topic><topic>Chi-Square Distribution</topic><topic>coronary disease</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - enzymology</topic><topic>Coronary Disease - immunology</topic><topic>Coronary Disease - mortality</topic><topic>Coronary heart disease</topic><topic>death</topic><topic>Denmark - epidemiology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>gelatinase B</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Matrix metalloproteinase-9</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - mortality</topic><topic>patients</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>risk</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eldrup, N</creatorcontrib><creatorcontrib>Kragelund, C</creatorcontrib><creatorcontrib>Steffensen, R</creatorcontrib><creatorcontrib>Nordestgaard, B.G</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eldrup, N</au><au>Kragelund, C</au><au>Steffensen, R</au><au>Nordestgaard, B.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognosis by C-reactive protein and matrix metalloproteinase-9 levels in stable coronary heart disease during 15 years of follow-up</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>22</volume><issue>8</issue><spage>677</spage><epage>683</epage><pages>677-683</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and Aim Elevated CRP and matrix metalloproteinase-9 associate with increased risk of cardiovascular events, possibly because these plasma proteins mark vulnerable atherosclerotic plaques. We tested the hypothesis that levels of C-reactive protein (CRP) and matrix metalloproteinase-9 associate with prognosis in patients with stable coronary heart disease. Methods and Results We measured baseline plasma CRP and matrix metalloproteinase-9 in 1090 patients with stable coronary heart disease and as the primary composite endpoint detected incident unstable angina, myocardial infarction and any death during 15 years of follow-up. CRP above versus below the median of 3.0 mg/L was associated with an increased cumulative incidence of unstable angina, myocardial infarction and any death combined (log-rank p < 0.0001). CRP above versus below the median had a corresponding hazard ratio of 1.5(95% CI, 1.3–1.8) after age adjustment, of 1.4(1.2–1.6) after multifactorial adjustment, and of 1.4(1.2–1.6) after multifactorial adjustment including degree of coronary disease. In contrast, matrix metalloproteinase-9 above versus below the median was not associated with risk of unstable angina, myocardial infarction and death. Conclusions Elevated CRP, but not elevated matrix metalloproteinase-9, associates with increased risk of unstable angina, myocardial infarction and death in patients with stable coronary heart disease.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21194909</pmid><doi>10.1016/j.numecd.2010.11.003</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Angina, Unstable - mortality Biomarkers - blood C-reactive protein C-Reactive Protein - analysis Cardiovascular Cause of Death Chi-Square Distribution coronary disease Coronary Disease - blood Coronary Disease - enzymology Coronary Disease - immunology Coronary Disease - mortality Coronary heart disease death Denmark - epidemiology Disease Progression Female Follow-Up Studies gelatinase B Humans Kaplan-Meier Estimate Male Matrix Metalloproteinase 9 - blood Matrix metalloproteinase-9 Middle Aged myocardial infarction Myocardial Infarction - mortality patients Prognosis Proportional Hazards Models Prospective Studies risk Risk Assessment Risk Factors Time Factors Up-Regulation |
| title | Prognosis by C-reactive protein and matrix metalloproteinase-9 levels in stable coronary heart disease during 15 years of follow-up |
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