Effect of Pomegranate Juice on Intestinal Transport and Pharmacokinetics of Nitrendipine in Rats

Pomegranate juice (PJ) is known to be a potent inhibitor of human cytochromes (CYP), particularly CYP2C9 and CYP3A4. The purpose of this study was to investigate the effect of oral PJ on the pharmacokinetics of nitrendipine (10 mg/kg) in rats. The effect of PJ was also investigated on the absorption...

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Veröffentlicht in:	Phytotherapy research 2012-08, Vol.26 (8), p.1240-1245
Hauptverfasser:	Voruganti, Swathi, Yamsani, Shravan Kumar, Ravula, Shiva Kumar, Gannu, Ramesh, Yamsani, Madhusudan Rao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Biological and medical sciences Biological Transport CYP3A Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - metabolism General pharmacology Half-Life Herb-Drug Interactions Intestine, Small - drug effects Intestine, Small - metabolism Male Medical sciences Molecular Structure nitrendipine Nitrendipine - blood Nitrendipine - pharmacokinetics P-glycoprotein Pharmacognosy. Homeopathy. Health food pharmacokinetics Pharmacology. Drug treatments Plant Extracts - administration & dosage Plant Extracts - pharmacology Pomegranate juice Punicaceae - metabolism Rats Rats, Wistar
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