Polymorphisms of genes related to endothelial cells are associated with primary biliary cirrhosis patients of Cretan origin

Abstract Background Primary biliary cirrhosis (PBC) is an organ specific autoimmune disease of still unidentified genetic etiology. We have shown that endothelins (ETs), produced by the liver endothelial cells are increased in PBC and may play a major pathogenetic role. Aims To study gene polymorphi...

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Veröffentlicht in:	Human immunology 2012-08, Vol.73 (8), p.829-835
Hauptverfasser:	Mantaka, Ai, Goulielmos, G.N, Koulentaki, M, Tsagournis, O, Voumvouraki, A, Kouroumalis, E.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alleles Allergy and Immunology CTLA-4 Antigen - genetics Endothelial Cells - metabolism Endothelial Cells - pathology Endothelin-1 - genetics Exons Female Genetic Association Studies Genetic Predisposition to Disease Greece - epidemiology Humans Introns Liver - metabolism Liver - pathology Liver Cirrhosis, Biliary - ethnology Liver Cirrhosis, Biliary - genetics Liver Cirrhosis, Biliary - pathology Male Middle Aged Nitric Oxide Synthase Type III - genetics Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Risk Factors
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