Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides
Chronic exposure of human skin to solar ultraviolet (UV) radiation causes photoaging. Naturally occurring phytochemicals are known to have anti-photoaging effects. The present study examined the effect of mangiferin isolated from Anemarrhena asphodeloides on wrinkle formation, skin thickness, and ch...
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| Veröffentlicht in: | European journal of pharmacology 2012-08, Vol.689 (1-3), p.38-44 |
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| container_title | European journal of pharmacology |
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| creator | Kim, Hui-Seong Song, Jae Hyoung Youn, Ui Joung Hyun, Jin Won Jeong, Woo Seok Lee, Mi Young Choi, Hwa Jung Lee, Hyeong-Kyu Chae, Sungwook |
| description | Chronic exposure of human skin to solar ultraviolet (UV) radiation causes photoaging. Naturally occurring phytochemicals are known to have anti-photoaging effects. The present study examined the effect of mangiferin isolated from Anemarrhena asphodeloides on wrinkle formation, skin thickness, and changes in collagen fibers in hairless mice. The in vitro effects and possible mechanism of mangiferin on UVB irradiation were determined in human keratinocyte (HEKa) cells. In vitro results showed that mangiferin reduced UVB-induced matrix metalloproteinase (MMP)-9 protein expression and enzyme activity and subsequent attenuation of UVB-induced phosphorylation of mitogen-activated protein kinase kinase1 (MEK) and extracellular signal-regulated kinase (ERK). In the in vivo studies, mangiferin inhibited UVB-induced mean length and mean depth of skin wrinkle based on skin replica, epidermal thickening, and damage to collagen fiber. Taken together, these results indicate that mangiferin exerts anti-photoaging activity in UVB-irradiated hairless mice by regulating MMP-9 expression through inhibition of MEK and ERK. |
| doi_str_mv | 10.1016/j.ejphar.2012.05.050 |
| format | Article |
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Naturally occurring phytochemicals are known to have anti-photoaging effects. The present study examined the effect of mangiferin isolated from Anemarrhena asphodeloides on wrinkle formation, skin thickness, and changes in collagen fibers in hairless mice. The in vitro effects and possible mechanism of mangiferin on UVB irradiation were determined in human keratinocyte (HEKa) cells. In vitro results showed that mangiferin reduced UVB-induced matrix metalloproteinase (MMP)-9 protein expression and enzyme activity and subsequent attenuation of UVB-induced phosphorylation of mitogen-activated protein kinase kinase1 (MEK) and extracellular signal-regulated kinase (ERK). In the in vivo studies, mangiferin inhibited UVB-induced mean length and mean depth of skin wrinkle based on skin replica, epidermal thickening, and damage to collagen fiber. Taken together, these results indicate that mangiferin exerts anti-photoaging activity in UVB-irradiated hairless mice by regulating MMP-9 expression through inhibition of MEK and ERK.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2012.05.050</identifier><identifier>PMID: 22683868</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anemarrhena ; Animals ; chronic exposure ; collagen ; enzyme activity ; Gene Expression Regulation, Enzymologic ; HEK293 Cells ; Humans ; in vivo studies ; irradiation ; Keratinocytes ; Mangiferin ; Matrix Metalloproteinase 9 - metabolism ; Matrix Metalloproteinase Inhibitors - isolation & purification ; Matrix Metalloproteinase Inhibitors - pharmacology ; Mice ; Mice, Hairless ; mitogen-activated protein kinase ; MMP-9 (Matrix metalloproteinase) ; pharmacology ; phosphorylation ; photoaging ; phytochemicals ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; protein synthesis ; Rhizome ; Skin aging ; Skin Aging - drug effects ; Skin Aging - pathology ; Ultraviolet B ; Ultraviolet Rays - adverse effects ; Xanthones - isolation & purification ; Xanthones - pharmacology</subject><ispartof>European journal of pharmacology, 2012-08, Vol.689 (1-3), p.38-44</ispartof><rights>2012 Elsevier B.V.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-e28597f064d83b5e8b810cfcf352374eadb50f01dc3a74c42b1c04f4c4b6901b3</citedby><cites>FETCH-LOGICAL-c386t-e28597f064d83b5e8b810cfcf352374eadb50f01dc3a74c42b1c04f4c4b6901b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014299912005092$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22683868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hui-Seong</creatorcontrib><creatorcontrib>Song, Jae Hyoung</creatorcontrib><creatorcontrib>Youn, Ui Joung</creatorcontrib><creatorcontrib>Hyun, Jin Won</creatorcontrib><creatorcontrib>Jeong, Woo Seok</creatorcontrib><creatorcontrib>Lee, Mi Young</creatorcontrib><creatorcontrib>Choi, Hwa Jung</creatorcontrib><creatorcontrib>Lee, Hyeong-Kyu</creatorcontrib><creatorcontrib>Chae, Sungwook</creatorcontrib><title>Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Chronic exposure of human skin to solar ultraviolet (UV) radiation causes photoaging. Naturally occurring phytochemicals are known to have anti-photoaging effects. The present study examined the effect of mangiferin isolated from Anemarrhena asphodeloides on wrinkle formation, skin thickness, and changes in collagen fibers in hairless mice. The in vitro effects and possible mechanism of mangiferin on UVB irradiation were determined in human keratinocyte (HEKa) cells. In vitro results showed that mangiferin reduced UVB-induced matrix metalloproteinase (MMP)-9 protein expression and enzyme activity and subsequent attenuation of UVB-induced phosphorylation of mitogen-activated protein kinase kinase1 (MEK) and extracellular signal-regulated kinase (ERK). In the in vivo studies, mangiferin inhibited UVB-induced mean length and mean depth of skin wrinkle based on skin replica, epidermal thickening, and damage to collagen fiber. Taken together, these results indicate that mangiferin exerts anti-photoaging activity in UVB-irradiated hairless mice by regulating MMP-9 expression through inhibition of MEK and ERK.</description><subject>Anemarrhena</subject><subject>Animals</subject><subject>chronic exposure</subject><subject>collagen</subject><subject>enzyme activity</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>in vivo studies</subject><subject>irradiation</subject><subject>Keratinocytes</subject><subject>Mangiferin</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Matrix Metalloproteinase Inhibitors - isolation & purification</subject><subject>Matrix Metalloproteinase Inhibitors - pharmacology</subject><subject>Mice</subject><subject>Mice, Hairless</subject><subject>mitogen-activated protein kinase</subject><subject>MMP-9 (Matrix metalloproteinase)</subject><subject>pharmacology</subject><subject>phosphorylation</subject><subject>photoaging</subject><subject>phytochemicals</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>protein synthesis</subject><subject>Rhizome</subject><subject>Skin aging</subject><subject>Skin Aging - drug effects</subject><subject>Skin Aging - pathology</subject><subject>Ultraviolet B</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>Xanthones - isolation & purification</subject><subject>Xanthones - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vEzEQxS0EomnhGyDwkcuGsfeffUEqFYVKrUCCcLW89rhx2LUXe1Pot8chhSPSSDOyfm_89IaQFwzWDFj3ZrfG3bzVac2B8TW0peARWTHRywp6xh-TFQBrKi6lPCGnOe8AoJW8fUpOOO9ELTqxIndXYesHv_gYaHR08-1d5YPdG7T0Z_Lh-4jUxTTpP4AOlt7cfK4kxV9zwpwPj8M9nXS49Q4LT32Oo16K2qU40fOAk05pi0FTnedttDhGbzE_I0-cHjM-f-hnZHP5_uvFx-r604eri_PryhR7S4VctLJ30DVW1EOLYhAMjDOubnndN6jt0IIDZk2t-8Y0fGAGGlemoZPAhvqMvD7unVP8sce8qMlng-OoA8Z9Vgx43_VSCFHQ5oiaFHNO6NScfHF_XyB1SFzt1DFxdUhcQVsKiuzlww_7YUL7T_Q34gK8OgJOR6Vvk89q86VsaMs5GpA9L8TbI4EliTuPSWXjMZQb-IRmUTb6_3v4DYAmnnA</recordid><startdate>20120815</startdate><enddate>20120815</enddate><creator>Kim, Hui-Seong</creator><creator>Song, Jae Hyoung</creator><creator>Youn, Ui Joung</creator><creator>Hyun, Jin Won</creator><creator>Jeong, Woo Seok</creator><creator>Lee, Mi Young</creator><creator>Choi, Hwa Jung</creator><creator>Lee, Hyeong-Kyu</creator><creator>Chae, Sungwook</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120815</creationdate><title>Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides</title><author>Kim, Hui-Seong ; Song, Jae Hyoung ; Youn, Ui Joung ; Hyun, Jin Won ; Jeong, Woo Seok ; Lee, Mi Young ; Choi, Hwa Jung ; Lee, Hyeong-Kyu ; Chae, Sungwook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-e28597f064d83b5e8b810cfcf352374eadb50f01dc3a74c42b1c04f4c4b6901b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anemarrhena</topic><topic>Animals</topic><topic>chronic exposure</topic><topic>collagen</topic><topic>enzyme activity</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>HEK293 Cells</topic><topic>Humans</topic><topic>in vivo studies</topic><topic>irradiation</topic><topic>Keratinocytes</topic><topic>Mangiferin</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>Matrix Metalloproteinase Inhibitors - isolation & purification</topic><topic>Matrix Metalloproteinase Inhibitors - pharmacology</topic><topic>Mice</topic><topic>Mice, Hairless</topic><topic>mitogen-activated protein kinase</topic><topic>MMP-9 (Matrix metalloproteinase)</topic><topic>pharmacology</topic><topic>phosphorylation</topic><topic>photoaging</topic><topic>phytochemicals</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>protein synthesis</topic><topic>Rhizome</topic><topic>Skin aging</topic><topic>Skin Aging - drug effects</topic><topic>Skin Aging - pathology</topic><topic>Ultraviolet B</topic><topic>Ultraviolet Rays - adverse effects</topic><topic>Xanthones - isolation & purification</topic><topic>Xanthones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hui-Seong</creatorcontrib><creatorcontrib>Song, Jae Hyoung</creatorcontrib><creatorcontrib>Youn, Ui Joung</creatorcontrib><creatorcontrib>Hyun, Jin Won</creatorcontrib><creatorcontrib>Jeong, Woo Seok</creatorcontrib><creatorcontrib>Lee, Mi Young</creatorcontrib><creatorcontrib>Choi, Hwa Jung</creatorcontrib><creatorcontrib>Lee, Hyeong-Kyu</creatorcontrib><creatorcontrib>Chae, Sungwook</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hui-Seong</au><au>Song, Jae Hyoung</au><au>Youn, Ui Joung</au><au>Hyun, Jin Won</au><au>Jeong, Woo Seok</au><au>Lee, Mi Young</au><au>Choi, Hwa Jung</au><au>Lee, Hyeong-Kyu</au><au>Chae, Sungwook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2012-08-15</date><risdate>2012</risdate><volume>689</volume><issue>1-3</issue><spage>38</spage><epage>44</epage><pages>38-44</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Chronic exposure of human skin to solar ultraviolet (UV) radiation causes photoaging. Naturally occurring phytochemicals are known to have anti-photoaging effects. The present study examined the effect of mangiferin isolated from Anemarrhena asphodeloides on wrinkle formation, skin thickness, and changes in collagen fibers in hairless mice. The in vitro effects and possible mechanism of mangiferin on UVB irradiation were determined in human keratinocyte (HEKa) cells. In vitro results showed that mangiferin reduced UVB-induced matrix metalloproteinase (MMP)-9 protein expression and enzyme activity and subsequent attenuation of UVB-induced phosphorylation of mitogen-activated protein kinase kinase1 (MEK) and extracellular signal-regulated kinase (ERK). In the in vivo studies, mangiferin inhibited UVB-induced mean length and mean depth of skin wrinkle based on skin replica, epidermal thickening, and damage to collagen fiber. Taken together, these results indicate that mangiferin exerts anti-photoaging activity in UVB-irradiated hairless mice by regulating MMP-9 expression through inhibition of MEK and ERK.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22683868</pmid><doi>10.1016/j.ejphar.2012.05.050</doi><tpages>7</tpages></addata></record> |
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| issn | 0014-2999 1879-0712 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anemarrhena Animals chronic exposure collagen enzyme activity Gene Expression Regulation, Enzymologic HEK293 Cells Humans in vivo studies irradiation Keratinocytes Mangiferin Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors - isolation & purification Matrix Metalloproteinase Inhibitors - pharmacology Mice Mice, Hairless mitogen-activated protein kinase MMP-9 (Matrix metalloproteinase) pharmacology phosphorylation photoaging phytochemicals Plant Extracts - isolation & purification Plant Extracts - pharmacology protein synthesis Rhizome Skin aging Skin Aging - drug effects Skin Aging - pathology Ultraviolet B Ultraviolet Rays - adverse effects Xanthones - isolation & purification Xanthones - pharmacology |
| title | Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides |
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