Fenofibrate Increases High-Density Lipoprotein and Sphingosine 1 Phosphate Concentrations Limiting Abdominal Aortic Aneurysm Progression in a Mouse Model

There are currently no acceptable treatments to limit progression of abdominal aortic aneurysm (AAA). Increased serum concentrations of high-density lipoprotein (HDL) are associated with reduced risk of developing an AAA. The present study aimed to assess the effects of fenofibrate on aortic dilatat...

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Veröffentlicht in:	The American journal of pathology 2012-08, Vol.181 (2), p.706-718
Hauptverfasser:	Krishna, Smriti M, Seto, Sai Wang, Moxon, Joseph V, Rush, Catherine, Walker, Philip J, Norman, Paul E, Golledge, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Aorta - drug effects Aorta - enzymology Aorta - pathology Aorta, Thoracic - drug effects Aorta, Thoracic - pathology Aortic Aneurysm, Abdominal - blood Aortic Aneurysm, Abdominal - complications Aortic Aneurysm, Abdominal - drug therapy Aortic Aneurysm, Abdominal - pathology Apoptosis - drug effects Azo Compounds - metabolism Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Dilatation, Pathologic - blood Dilatation, Pathologic - complications Dilatation, Pathologic - drug therapy Dilatation, Pathologic - pathology Disease Models, Animal Disease Progression Diseases of the aorta Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelial Cells - pathology Fenofibrate - pharmacology Fenofibrate - therapeutic use Inflammation - blood Inflammation - complications Inflammation - drug therapy Inflammation - pathology Investigative techniques, diagnostic techniques (general aspects) Kidney - blood supply Kidney - drug effects Kidney - pathology Lipoproteins, HDL - blood Lysophospholipids - blood Male Medical sciences Mice Mice, Inbred C57BL Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-akt - metabolism Receptors, Lysosphingolipid - metabolism Sphingosine - analogs & derivatives Sphingosine - blood Treatment Outcome Up-Regulation - drug effects
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