Serotonin potentiates high-glucose-induced endothelial injury: the role of serotonin and 5-HT(2A) receptors in promoting thrombosis in diabetes

To clarify the involvement of 5-hydroxytryptamine (5-HT) in promotion of thrombogenesis in diabetes, we examined the inhibitory effect of sarpogrelate, a 5-HT(2A) receptor antagonist, on thrombus formation in diabetic rats. In streptozotocin-induced diabetic rats, polyethylene tube-induced thrombus...

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Veröffentlicht in:	Journal of pharmacological sciences 2012, Vol.119 (3), p.243-250
Hauptverfasser:	Yamada, Kumi, Niki, Hisae, Nagai, Hitoshi, Nishikawa, Masakuni, Nakagawa, Haruto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspirin - pharmacology Cells, Cultured Cilostazol Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Fibrinolytic Agents - pharmacology Glucose - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Male Platelet Aggregation - drug effects Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2A - metabolism Serotonin - metabolism Serotonin - pharmacology Serotonin 5-HT2 Receptor Antagonists - pharmacology Succinates - pharmacology Tetrazoles - pharmacology Thrombosis - drug therapy Thrombosis - metabolism Thrombosis - prevention & control Vascular Cell Adhesion Molecule-1 - metabolism
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