Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation

Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The ef...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-08, Vol.22 (15), p.5051-5054
Hauptverfasser:	Nemoto, Hisao, Katagiri, Ayato, Kamiya, Masaki, Matsushita, Tsuyoshi, Hattori, Hatsuhiko, Matsumura, Kosuke, Itou, Tomohiro, Kawamura, Tomoyuki, Kita, Toshiyuki, Nishida, Hana, Arakaki, Naokatu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fat-reducing Glycerol Glycerol - chemical synthesis Glycerol - chemistry Medical sciences Mitochondria Mitochondria - metabolism Pharmacology. Drug treatments Resveratrol Solubility Stilbenes - chemical synthesis Stilbenes - chemistry structure-activity relationships Water - chemistry Water-solubility
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