Solid pseudopapillary neoplasm, pancreas type, presenting as a primary ovarian neoplasm
Summary Solid pseudopapillary neoplasm has historically been associated with the pancreas, categorized as a tumor of low malignancy. Recently, solid pseudopapillary neoplasm was reported to arise as a primary ovarian tumor in 3 women. We report a fourth case identified in a 48 year-old woman with an...
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| Veröffentlicht in: | Human pathology 2012-08, Vol.43 (8), p.1339-1343 |
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| container_title | Human pathology |
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| creator | Stoll, Lisa M., MD, MPH Parvataneni, Ram, MD, MPH Johnson, Michael W., MD, PhD Gui, Dorina, MD, PhD Dorigo, Oliver, MD, PhD Sullivan, Peggy, MD |
| description | Summary Solid pseudopapillary neoplasm has historically been associated with the pancreas, categorized as a tumor of low malignancy. Recently, solid pseudopapillary neoplasm was reported to arise as a primary ovarian tumor in 3 women. We report a fourth case identified in a 48 year-old woman with an 8-cm left ovarian mass. A left salpingo-oophorectomy was performed. Microscopic examination demonstrated a predominately cystic neoplasm comprised of solid nests of cells with an epithelioid to plasmacytoid appearance, associated with blood vessels, hemorrhage, and degenerative changes, that is, pseudopapillary structures. The tumor cells stained focally for pancytokeratin, progesterone receptor, and CD57 with diffuse nuclear expression of β -catenin. Ki-67 was 5% to 10%. Synaptophysin, inhibin, and E-cadherin stains were negative. Clinical and radiologic follow-up of our patient demonstrated no pancreatic lesions. This is a rare report of a primary ovarian solid pseudopapillary neoplasm. Prolonged follow-up is needed to determine how this case will fare clinically. |
| doi_str_mv | 10.1016/j.humpath.2011.12.018 |
| format | Article |
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Recently, solid pseudopapillary neoplasm was reported to arise as a primary ovarian tumor in 3 women. We report a fourth case identified in a 48 year-old woman with an 8-cm left ovarian mass. A left salpingo-oophorectomy was performed. Microscopic examination demonstrated a predominately cystic neoplasm comprised of solid nests of cells with an epithelioid to plasmacytoid appearance, associated with blood vessels, hemorrhage, and degenerative changes, that is, pseudopapillary structures. The tumor cells stained focally for pancytokeratin, progesterone receptor, and CD57 with diffuse nuclear expression of β -catenin. Ki-67 was 5% to 10%. Synaptophysin, inhibin, and E-cadherin stains were negative. Clinical and radiologic follow-up of our patient demonstrated no pancreatic lesions. This is a rare report of a primary ovarian solid pseudopapillary neoplasm. Prolonged follow-up is needed to determine how this case will fare clinically.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2011.12.018</identifier><identifier>PMID: 22534259</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cancer ; Cystectomy ; Family medical history ; Female ; Humans ; Hypothyroidism ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - surgery ; Ovariectomy ; Ovary ; Pancreas ; Pancreas - pathology ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Solid pseudopapillary tumor ; Tumors ; Women</subject><ispartof>Human pathology, 2012-08, Vol.43 (8), p.1339-1343</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-84ed0543b9ac9714791af6304c9dfb638103514e092031ce6a324ffb5c5c6ea3</citedby><cites>FETCH-LOGICAL-c525t-84ed0543b9ac9714791af6304c9dfb638103514e092031ce6a324ffb5c5c6ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2011.12.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26175784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22534259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoll, Lisa M., MD, MPH</creatorcontrib><creatorcontrib>Parvataneni, Ram, MD, MPH</creatorcontrib><creatorcontrib>Johnson, Michael W., MD, PhD</creatorcontrib><creatorcontrib>Gui, Dorina, MD, PhD</creatorcontrib><creatorcontrib>Dorigo, Oliver, MD, PhD</creatorcontrib><creatorcontrib>Sullivan, Peggy, MD</creatorcontrib><title>Solid pseudopapillary neoplasm, pancreas type, presenting as a primary ovarian neoplasm</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Solid pseudopapillary neoplasm has historically been associated with the pancreas, categorized as a tumor of low malignancy. Recently, solid pseudopapillary neoplasm was reported to arise as a primary ovarian tumor in 3 women. We report a fourth case identified in a 48 year-old woman with an 8-cm left ovarian mass. A left salpingo-oophorectomy was performed. Microscopic examination demonstrated a predominately cystic neoplasm comprised of solid nests of cells with an epithelioid to plasmacytoid appearance, associated with blood vessels, hemorrhage, and degenerative changes, that is, pseudopapillary structures. The tumor cells stained focally for pancytokeratin, progesterone receptor, and CD57 with diffuse nuclear expression of β -catenin. Ki-67 was 5% to 10%. Synaptophysin, inhibin, and E-cadherin stains were negative. Clinical and radiologic follow-up of our patient demonstrated no pancreatic lesions. This is a rare report of a primary ovarian solid pseudopapillary neoplasm. Prolonged follow-up is needed to determine how this case will fare clinically.</description><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cystectomy</subject><subject>Family medical history</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Ovariectomy</subject><subject>Ovary</subject><subject>Pancreas</subject><subject>Pancreas - pathology</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Solid pseudopapillary tumor</subject><subject>Tumors</subject><subject>Women</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1TAQhoMo7nH1JygFEbywNZOPpr1RZPELFrzYBS9DTjp1c-yXSbtw_r1TTt2FvfEqJDzvZOZhGHsJvAAO5ftDcbP0k5tvCsEBChAFh-oR24GWIq9kLR6zHeeqzCsw5ow9S-nACdRKP2VnQmiphK537OfV2IUmmxIuzTi5KXSdi8dswHHqXOrfZZMbfESXsvk4IV0jJhzmMPzK6M3RPfRrYLx1MbjhLvicPWldl_DFdp6z6y-fry--5Zc_vn6_-HSZey30nFcKG66V3NfO1waUqcG1peTK1027L2UFXGpQyGvBJXgsnRSqbffaa1-ik-fs7ansFMc_C6bZ9iF5pCGokSVZ4MJIo6U2hL5-gB7GJQ7UHFGyrHUJFRClT5SPY0oRW7tNSJBdxduD3cTbVbwFYUk85V5t1Zd9j81d6p9pAt5sgEvedW0kryHdcyUYbSpF3McTh2TtNmC0yQccPDYhop9tM4b_tvLhQQXfhSHQp7_xiOl-apsoYK_WLVmXBIBzLYyQfwGqgrg1</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Stoll, Lisa M., MD, MPH</creator><creator>Parvataneni, Ram, MD, MPH</creator><creator>Johnson, Michael W., MD, PhD</creator><creator>Gui, Dorina, MD, PhD</creator><creator>Dorigo, Oliver, MD, PhD</creator><creator>Sullivan, Peggy, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Solid pseudopapillary neoplasm, pancreas type, presenting as a primary ovarian neoplasm</title><author>Stoll, Lisa M., MD, MPH ; Parvataneni, Ram, MD, MPH ; Johnson, Michael W., MD, PhD ; Gui, Dorina, MD, PhD ; Dorigo, Oliver, MD, PhD ; Sullivan, Peggy, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-84ed0543b9ac9714791af6304c9dfb638103514e092031ce6a324ffb5c5c6ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cystectomy</topic><topic>Family medical history</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Ovariectomy</topic><topic>Ovary</topic><topic>Pancreas</topic><topic>Pancreas - pathology</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Solid pseudopapillary tumor</topic><topic>Tumors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoll, Lisa M., MD, MPH</creatorcontrib><creatorcontrib>Parvataneni, Ram, MD, MPH</creatorcontrib><creatorcontrib>Johnson, Michael W., MD, PhD</creatorcontrib><creatorcontrib>Gui, Dorina, MD, PhD</creatorcontrib><creatorcontrib>Dorigo, Oliver, MD, PhD</creatorcontrib><creatorcontrib>Sullivan, Peggy, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoll, Lisa M., MD, MPH</au><au>Parvataneni, Ram, MD, MPH</au><au>Johnson, Michael W., MD, PhD</au><au>Gui, Dorina, MD, PhD</au><au>Dorigo, Oliver, MD, PhD</au><au>Sullivan, Peggy, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid pseudopapillary neoplasm, pancreas type, presenting as a primary ovarian neoplasm</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>43</volume><issue>8</issue><spage>1339</spage><epage>1343</epage><pages>1339-1343</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Solid pseudopapillary neoplasm has historically been associated with the pancreas, categorized as a tumor of low malignancy. Recently, solid pseudopapillary neoplasm was reported to arise as a primary ovarian tumor in 3 women. We report a fourth case identified in a 48 year-old woman with an 8-cm left ovarian mass. A left salpingo-oophorectomy was performed. Microscopic examination demonstrated a predominately cystic neoplasm comprised of solid nests of cells with an epithelioid to plasmacytoid appearance, associated with blood vessels, hemorrhage, and degenerative changes, that is, pseudopapillary structures. The tumor cells stained focally for pancytokeratin, progesterone receptor, and CD57 with diffuse nuclear expression of β -catenin. Ki-67 was 5% to 10%. Synaptophysin, inhibin, and E-cadherin stains were negative. Clinical and radiologic follow-up of our patient demonstrated no pancreatic lesions. This is a rare report of a primary ovarian solid pseudopapillary neoplasm. Prolonged follow-up is needed to determine how this case will fare clinically.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22534259</pmid><doi>10.1016/j.humpath.2011.12.018</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Cancer Cystectomy Family medical history Female Humans Hypothyroidism Investigative techniques, diagnostic techniques (general aspects) Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Ovariectomy Ovary Pancreas Pancreas - pathology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Solid pseudopapillary tumor Tumors Women |
| title | Solid pseudopapillary neoplasm, pancreas type, presenting as a primary ovarian neoplasm |
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