Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival
Background EphA3, a member of the Eph receptor tyrosine kinases, plays important roles in tumor angiogenesis and progression. However, the function of EphA3 in solid tumors has not been widely studied. We aimed to explore EphA3 expression in gastric carcinoma and analyze its role as a potential prog...
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| Veröffentlicht in: | Journal of gastroenterology 2012-07, Vol.47 (7), p.785-794 |
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| creator | Xi, Hong-Qing Wu, Xiao-Song Wei, Bo Chen, Lin |
| description | Background
EphA3, a member of the Eph receptor tyrosine kinases, plays important roles in tumor angiogenesis and progression. However, the function of EphA3 in solid tumors has not been widely studied. We aimed to explore EphA3 expression in gastric carcinoma and analyze its role as a potential prognostic factor.
Methods
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to assess EphA3 mRNA in a normal gastric mucosa cell line and carcinoma cell lines. Immunohistochemistry for EphA3 and vascular endothelial growth factor (VEGF) was performed in 318 cases of gastric carcinoma. CD34 immunohistochemical staining was used for microvessel density (MVD) counting. Western blotting was used to analyze EphA3 expression in the cell lines and to determine the expression of EphA3 and VEGF in 75 cases of gastric carcinoma and matched normal mucosa.
Results
EphA3 mRNA and protein expression was significantly higher in gastric cancer than that in normal mucosa (all
P
|
| doi_str_mv | 10.1007/s00535-012-0549-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1027373094</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714585942</galeid><sourcerecordid>A714585942</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-6d3062bed3513e79720f7f9c26bf59de5644cca87007487dfb8b494e0d151b2f3</originalsourceid><addsrcrecordid>eNp1kU1vFSEUhonR2NvqD3BjSNy4mcrnMLi7aao1aeJG14RhDlOaGbjCTKv_Xia3fkbDgnB4zsvLeRF6Qck5JUS9KYRILhtCWUOk0I14hHZU1IrUjD1GO6KFaChV4gSdlnJLCOVEdk_RCWNcEkXIDrl9DznbuGD4eshQSkgRJ48vDzd7jkPEoy1LDg47m12IabZvsUs5w2SXDb0Pyw1e1jllbOMY0ggRSij1MOCy5rtwZ6dn6Im3U4HnD_sZ-vzu8tPFVXP98f2Hi_1144RmS9MOnLSsh4FLykFpxYhXXjvW9l7qAWQrhHO2q76V6NTg-64XWgAZqKQ98_wMvT7qHnL6skJZzByKg2myEdJaDCVMccXrVCr66i_0Nq05Vncb1XayTkj_okY7gQnRpyVbt4mavaJCdlILVqnzf1B1DTAHlyL4UOt_NNBjg8uplAzeHHKYbf5W3zZbsOYYrKnBmi1Ysxl--WB47WcYfnb8SLIC7AiUehVHyL__6H-q3wG8oavm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1026852239</pqid></control><display><type>article</type><title>Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Xi, Hong-Qing ; Wu, Xiao-Song ; Wei, Bo ; Chen, Lin</creator><creatorcontrib>Xi, Hong-Qing ; Wu, Xiao-Song ; Wei, Bo ; Chen, Lin</creatorcontrib><description><![CDATA[Background
EphA3, a member of the Eph receptor tyrosine kinases, plays important roles in tumor angiogenesis and progression. However, the function of EphA3 in solid tumors has not been widely studied. We aimed to explore EphA3 expression in gastric carcinoma and analyze its role as a potential prognostic factor.
Methods
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to assess EphA3 mRNA in a normal gastric mucosa cell line and carcinoma cell lines. Immunohistochemistry for EphA3 and vascular endothelial growth factor (VEGF) was performed in 318 cases of gastric carcinoma. CD34 immunohistochemical staining was used for microvessel density (MVD) counting. Western blotting was used to analyze EphA3 expression in the cell lines and to determine the expression of EphA3 and VEGF in 75 cases of gastric carcinoma and matched normal mucosa.
Results
EphA3 mRNA and protein expression was significantly higher in gastric cancer than that in normal mucosa (all
P
< 0.001). EphA3 was significantly correlated with TNM stage and poor prognosis (all
P
< 0.001). Multivariate analysis showed that EphA3 had an independent effect on survival (
P
= 0.037). EphA3 was positively correlated with VEGF (
P
< 0.001), and MVD (
P
< 0.001). According to Western blot analysis, both EphA3 and VEGF expression were significantly higher in carcinoma than that in normal mucosa (all
P
< 0.001). A positive correlation was observed between EphA3 and VEGF expression in cancer (
P
< 0.001,
r
= 0.513).
Conclusions
EphA3 may play important roles in the angiogenesis and prognosis of gastric carcinoma, and thus may become a useful target for therapeutic intervention and a potential indicator for clinical assessment of tumor prognosis.]]></description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-012-0549-4</identifier><identifier>PMID: 22350700</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Abdominal Surgery ; Adult ; Aged, 80 and over ; Analysis ; Cancer ; Carcinoma ; Case-Control Studies ; Cell Line ; Cell Line, Tumor ; Colorectal Surgery ; Development and progression ; Female ; Gastric Mucosa - metabolism ; Gastroenterology ; Gene Expression Regulation, Neoplastic ; Health aspects ; Hepatology ; Humans ; Immunohistochemistry ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Neovascularization, Pathologic - genetics ; Neovascularization, Pathologic - pathology ; Original Article—Alimentary Tract ; Prognosis ; Receptor Protein-Tyrosine Kinases - genetics ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; RNA, Messenger - metabolism ; Stomach cancer ; Stomach Neoplasms - blood supply ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology ; Surgical Oncology ; Survival Rate ; Tyrosine ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - metabolism ; Young Adult</subject><ispartof>Journal of gastroenterology, 2012-07, Vol.47 (7), p.785-794</ispartof><rights>Springer 2012</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-6d3062bed3513e79720f7f9c26bf59de5644cca87007487dfb8b494e0d151b2f3</citedby><cites>FETCH-LOGICAL-c492t-6d3062bed3513e79720f7f9c26bf59de5644cca87007487dfb8b494e0d151b2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-012-0549-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-012-0549-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22350700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xi, Hong-Qing</creatorcontrib><creatorcontrib>Wu, Xiao-Song</creatorcontrib><creatorcontrib>Wei, Bo</creatorcontrib><creatorcontrib>Chen, Lin</creatorcontrib><title>Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description><![CDATA[Background
EphA3, a member of the Eph receptor tyrosine kinases, plays important roles in tumor angiogenesis and progression. However, the function of EphA3 in solid tumors has not been widely studied. We aimed to explore EphA3 expression in gastric carcinoma and analyze its role as a potential prognostic factor.
Methods
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to assess EphA3 mRNA in a normal gastric mucosa cell line and carcinoma cell lines. Immunohistochemistry for EphA3 and vascular endothelial growth factor (VEGF) was performed in 318 cases of gastric carcinoma. CD34 immunohistochemical staining was used for microvessel density (MVD) counting. Western blotting was used to analyze EphA3 expression in the cell lines and to determine the expression of EphA3 and VEGF in 75 cases of gastric carcinoma and matched normal mucosa.
Results
EphA3 mRNA and protein expression was significantly higher in gastric cancer than that in normal mucosa (all
P
< 0.001). EphA3 was significantly correlated with TNM stage and poor prognosis (all
P
< 0.001). Multivariate analysis showed that EphA3 had an independent effect on survival (
P
= 0.037). EphA3 was positively correlated with VEGF (
P
< 0.001), and MVD (
P
< 0.001). According to Western blot analysis, both EphA3 and VEGF expression were significantly higher in carcinoma than that in normal mucosa (all
P
< 0.001). A positive correlation was observed between EphA3 and VEGF expression in cancer (
P
< 0.001,
r
= 0.513).
Conclusions
EphA3 may play important roles in the angiogenesis and prognosis of gastric carcinoma, and thus may become a useful target for therapeutic intervention and a potential indicator for clinical assessment of tumor prognosis.]]></description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Case-Control Studies</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Colorectal Surgery</subject><subject>Development and progression</subject><subject>Female</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastroenterology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Original Article—Alimentary Tract</subject><subject>Prognosis</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA</subject><subject>RNA, Messenger - metabolism</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - blood supply</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Tyrosine</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>Young Adult</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1vFSEUhonR2NvqD3BjSNy4mcrnMLi7aao1aeJG14RhDlOaGbjCTKv_Xia3fkbDgnB4zsvLeRF6Qck5JUS9KYRILhtCWUOk0I14hHZU1IrUjD1GO6KFaChV4gSdlnJLCOVEdk_RCWNcEkXIDrl9DznbuGD4eshQSkgRJ48vDzd7jkPEoy1LDg47m12IabZvsUs5w2SXDb0Pyw1e1jllbOMY0ggRSij1MOCy5rtwZ6dn6Im3U4HnD_sZ-vzu8tPFVXP98f2Hi_1144RmS9MOnLSsh4FLykFpxYhXXjvW9l7qAWQrhHO2q76V6NTg-64XWgAZqKQ98_wMvT7qHnL6skJZzByKg2myEdJaDCVMccXrVCr66i_0Nq05Vncb1XayTkj_okY7gQnRpyVbt4mavaJCdlILVqnzf1B1DTAHlyL4UOt_NNBjg8uplAzeHHKYbf5W3zZbsOYYrKnBmi1Ysxl--WB47WcYfnb8SLIC7AiUehVHyL__6H-q3wG8oavm</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Xi, Hong-Qing</creator><creator>Wu, Xiao-Song</creator><creator>Wei, Bo</creator><creator>Chen, Lin</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival</title><author>Xi, Hong-Qing ; Wu, Xiao-Song ; Wei, Bo ; Chen, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-6d3062bed3513e79720f7f9c26bf59de5644cca87007487dfb8b494e0d151b2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Case-Control Studies</topic><topic>Cell Line</topic><topic>Cell Line, Tumor</topic><topic>Colorectal Surgery</topic><topic>Development and progression</topic><topic>Female</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastroenterology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Original Article—Alimentary Tract</topic><topic>Prognosis</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA</topic><topic>RNA, Messenger - metabolism</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - blood supply</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Tyrosine</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xi, Hong-Qing</creatorcontrib><creatorcontrib>Wu, Xiao-Song</creatorcontrib><creatorcontrib>Wei, Bo</creatorcontrib><creatorcontrib>Chen, Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xi, Hong-Qing</au><au>Wu, Xiao-Song</au><au>Wei, Bo</au><au>Chen, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>47</volume><issue>7</issue><spage>785</spage><epage>794</epage><pages>785-794</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract><![CDATA[Background
EphA3, a member of the Eph receptor tyrosine kinases, plays important roles in tumor angiogenesis and progression. However, the function of EphA3 in solid tumors has not been widely studied. We aimed to explore EphA3 expression in gastric carcinoma and analyze its role as a potential prognostic factor.
Methods
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to assess EphA3 mRNA in a normal gastric mucosa cell line and carcinoma cell lines. Immunohistochemistry for EphA3 and vascular endothelial growth factor (VEGF) was performed in 318 cases of gastric carcinoma. CD34 immunohistochemical staining was used for microvessel density (MVD) counting. Western blotting was used to analyze EphA3 expression in the cell lines and to determine the expression of EphA3 and VEGF in 75 cases of gastric carcinoma and matched normal mucosa.
Results
EphA3 mRNA and protein expression was significantly higher in gastric cancer than that in normal mucosa (all
P
< 0.001). EphA3 was significantly correlated with TNM stage and poor prognosis (all
P
< 0.001). Multivariate analysis showed that EphA3 had an independent effect on survival (
P
= 0.037). EphA3 was positively correlated with VEGF (
P
< 0.001), and MVD (
P
< 0.001). According to Western blot analysis, both EphA3 and VEGF expression were significantly higher in carcinoma than that in normal mucosa (all
P
< 0.001). A positive correlation was observed between EphA3 and VEGF expression in cancer (
P
< 0.001,
r
= 0.513).
Conclusions
EphA3 may play important roles in the angiogenesis and prognosis of gastric carcinoma, and thus may become a useful target for therapeutic intervention and a potential indicator for clinical assessment of tumor prognosis.]]></abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>22350700</pmid><doi>10.1007/s00535-012-0549-4</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2012-07, Vol.47 (7), p.785-794 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Adult Aged, 80 and over Analysis Cancer Carcinoma Case-Control Studies Cell Line Cell Line, Tumor Colorectal Surgery Development and progression Female Gastric Mucosa - metabolism Gastroenterology Gene Expression Regulation, Neoplastic Health aspects Hepatology Humans Immunohistochemistry Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Multivariate Analysis Neoplasm Staging Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Original Article—Alimentary Tract Prognosis Receptor Protein-Tyrosine Kinases - genetics Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Messenger - metabolism Stomach cancer Stomach Neoplasms - blood supply Stomach Neoplasms - genetics Stomach Neoplasms - pathology Surgical Oncology Survival Rate Tyrosine Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Young Adult |
| title | Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival |
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