Production of the antimicrobial peptides Caseicin A and B by Bacillus isolates growing on sodium caseinate

Aims: The aim of this study was to identify Bacillus isolates capable of degrading sodium caseinate and subsequently to generate bioactive peptides with antimicrobial activity. Methods and results: Sodium caseinate (2·5% w/v) was inoculated separately with 16 Bacillus isolates and allowed to ferment...

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Veröffentlicht in:	Letters in applied microbiology 2012-08, Vol.55 (2), p.141-148
Hauptverfasser:	Kent, R.M, Guinane, C.M, O’Connor, P.M, Fitzgerald, G.F, Hill, C, Stanton, C, Ross, R.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - pharmacology antimicrobial peptides antimicrobial properties Bacillus Bacillus - isolation & purification Bacillus - metabolism Bacillus cereus Bacillus thuringiensis bioactives Biological and medical sciences casein Caseins - metabolism Cattle Chromatography, High Pressure Liquid - methods Cronobacter sakazakii Cronobacter sakazakii - drug effects enzymes Fundamental and applied biological sciences. Psychology gels infant formulas mass spectrometry Microbial Sensitivity Tests Microbiology new methods pathogens Peptide Fragments - metabolism sodium caseinate
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Beschreibung
Zusammenfassung:	Aims: The aim of this study was to identify Bacillus isolates capable of degrading sodium caseinate and subsequently to generate bioactive peptides with antimicrobial activity. Methods and results: Sodium caseinate (2·5% w/v) was inoculated separately with 16 Bacillus isolates and allowed to ferment overnight. Protein breakdown in the fermentates was analysed using gel permeation‐HPLC (GP‐HPLC) and screened for peptides (
ISSN:	0266-8254 1472-765X
DOI:	10.1111/j.1472-765X.2012.03271.x