Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole-Induced Seizure in Rats
Flavonoids are important constituents of food and beverages and have several neuropharmacological activities. Many of these compounds are ligands for γ‐aminobutyric acid type A receptors in the central nervous system. This study aimed to investigate the anticonvulsant effects of intracerebroventricu...
Gespeichert in:
| Veröffentlicht in: | Chemical biology & drug design 2012-08, Vol.80 (2), p.274-278 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 278 |
|---|---|
| container_issue | 2 |
| container_start_page | 274 |
| container_title | Chemical biology & drug design |
| container_volume | 80 |
| creator | Abbasi, Esmail Nassiri-Asl, Marjan Shafeei, Mahsa Sheikhi, Mehdi |
| description | Flavonoids are important constituents of food and beverages and have several neuropharmacological activities. Many of these compounds are ligands for γ‐aminobutyric acid type A receptors in the central nervous system. This study aimed to investigate the anticonvulsant effects of intracerebroventricularly administered vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants, in rats treated with pentylenetetrazole (90 mg/kg, intraperitoneally) and to clarify the underlying mechanism. Vitexin (100 and 200 μm, i.c.v) affected minimal clonic seizures and generalized tonic–clonic seizures induced by pentylenetetrazole by increasing the seizure onset time. Pretreatment with flumazenil suppressed the anticonvulsant effects of vitexin during the onset of both the seizures. These results indicate that vitexin has anticonvulsant effects in the brain, possibly through interaction at the benzodiazepine site of the γ‐aminobutyric acid type A receptor complex.
Vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants. The anticonvulsant effects of vitexin were investigated in rats. Vitexin affected minimal clonic seizures and generalized toni–clonic seizures induced by pentylenetetrazole. |
| doi_str_mv | 10.1111/j.1747-0285.2012.01400.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1027041615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1027041615</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5240-d239a9ff243d150e8e5c1cb67d7ea8c0d66971327f8b07b9ec1338df9aa152413</originalsourceid><addsrcrecordid>eNqNkM1u1DAUhS0EoqXwCshLFk3wb5xskGDaDpWqgviVWGB57GvJQyZu7aTM9OlxmDJrvPGRfO535Q8hTElNy3m9rqkSqiKslTUjlNWECkLq7SN0fHh4fMhKHaFnOa8JEUKy9ik6YkxKIXhzjH5ew5TiTYoj2DHcAT73vqSMo8ffwgjbMJxigy96cxeHGNwpjgP-CMO462GAEcZk7mMP1eXgJgsOf4ZwPyXAYcCfzJifoyfe9BlePNwn6OvF-ZfF--rqw_Jy8faqspIJUjnGO9N5zwR3VBJoQVpqV41yCkxriWuaTlHOlG9XRK06sJTz1vnOGFoAlJ-gV3tu-cntBHnUm5At9L0ZIE5Z02KBCNpQWartvmpTzDmB1zcpbEzalZKe7eq1nsXpWaKe7eq_dvW2jL582DKtNuAOg_90lsKbfeF36GH332C9eHd2NscCqPaAkIv7A8CkX7pRXEn9_Xqpl4zwjv8oDP4HoHaXZg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1027041615</pqid></control><display><type>article</type><title>Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole-Induced Seizure in Rats</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Abbasi, Esmail ; Nassiri-Asl, Marjan ; Shafeei, Mahsa ; Sheikhi, Mehdi</creator><creatorcontrib>Abbasi, Esmail ; Nassiri-Asl, Marjan ; Shafeei, Mahsa ; Sheikhi, Mehdi</creatorcontrib><description>Flavonoids are important constituents of food and beverages and have several neuropharmacological activities. Many of these compounds are ligands for γ‐aminobutyric acid type A receptors in the central nervous system. This study aimed to investigate the anticonvulsant effects of intracerebroventricularly administered vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants, in rats treated with pentylenetetrazole (90 mg/kg, intraperitoneally) and to clarify the underlying mechanism. Vitexin (100 and 200 μm, i.c.v) affected minimal clonic seizures and generalized tonic–clonic seizures induced by pentylenetetrazole by increasing the seizure onset time. Pretreatment with flumazenil suppressed the anticonvulsant effects of vitexin during the onset of both the seizures. These results indicate that vitexin has anticonvulsant effects in the brain, possibly through interaction at the benzodiazepine site of the γ‐aminobutyric acid type A receptor complex.
Vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants. The anticonvulsant effects of vitexin were investigated in rats. Vitexin affected minimal clonic seizures and generalized toni–clonic seizures induced by pentylenetetrazole.</description><identifier>ISSN: 1747-0277</identifier><identifier>EISSN: 1747-0285</identifier><identifier>DOI: 10.1111/j.1747-0285.2012.01400.x</identifier><identifier>PMID: 22554436</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Anticonvulsants - pharmacology ; Anticonvulsants - therapeutic use ; Apigenin - pharmacology ; Apigenin - therapeutic use ; flavonoids ; Flumazenil - pharmacology ; GABA Modulators - pharmacology ; GABAA ; gamma-Aminobutyric Acid - metabolism ; Male ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Pennisetum - chemistry ; Pentylenetetrazole ; Rats ; Rats, Wistar ; seizure ; Seizures - chemically induced ; Seizures - drug therapy ; vitexin</subject><ispartof>Chemical biology & drug design, 2012-08, Vol.80 (2), p.274-278</ispartof><rights>2012 John Wiley & Sons A/S</rights><rights>2012 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5240-d239a9ff243d150e8e5c1cb67d7ea8c0d66971327f8b07b9ec1338df9aa152413</citedby><cites>FETCH-LOGICAL-c5240-d239a9ff243d150e8e5c1cb67d7ea8c0d66971327f8b07b9ec1338df9aa152413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1747-0285.2012.01400.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1747-0285.2012.01400.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22554436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abbasi, Esmail</creatorcontrib><creatorcontrib>Nassiri-Asl, Marjan</creatorcontrib><creatorcontrib>Shafeei, Mahsa</creatorcontrib><creatorcontrib>Sheikhi, Mehdi</creatorcontrib><title>Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole-Induced Seizure in Rats</title><title>Chemical biology & drug design</title><addtitle>Chem Biol Drug Des</addtitle><description>Flavonoids are important constituents of food and beverages and have several neuropharmacological activities. Many of these compounds are ligands for γ‐aminobutyric acid type A receptors in the central nervous system. This study aimed to investigate the anticonvulsant effects of intracerebroventricularly administered vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants, in rats treated with pentylenetetrazole (90 mg/kg, intraperitoneally) and to clarify the underlying mechanism. Vitexin (100 and 200 μm, i.c.v) affected minimal clonic seizures and generalized tonic–clonic seizures induced by pentylenetetrazole by increasing the seizure onset time. Pretreatment with flumazenil suppressed the anticonvulsant effects of vitexin during the onset of both the seizures. These results indicate that vitexin has anticonvulsant effects in the brain, possibly through interaction at the benzodiazepine site of the γ‐aminobutyric acid type A receptor complex.
Vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants. The anticonvulsant effects of vitexin were investigated in rats. Vitexin affected minimal clonic seizures and generalized toni–clonic seizures induced by pentylenetetrazole.</description><subject>Animals</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Apigenin - pharmacology</subject><subject>Apigenin - therapeutic use</subject><subject>flavonoids</subject><subject>Flumazenil - pharmacology</subject><subject>GABA Modulators - pharmacology</subject><subject>GABAA</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Male</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Pennisetum - chemistry</subject><subject>Pentylenetetrazole</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>seizure</subject><subject>Seizures - chemically induced</subject><subject>Seizures - drug therapy</subject><subject>vitexin</subject><issn>1747-0277</issn><issn>1747-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1DAUhS0EoqXwCshLFk3wb5xskGDaDpWqgviVWGB57GvJQyZu7aTM9OlxmDJrvPGRfO535Q8hTElNy3m9rqkSqiKslTUjlNWECkLq7SN0fHh4fMhKHaFnOa8JEUKy9ik6YkxKIXhzjH5ew5TiTYoj2DHcAT73vqSMo8ffwgjbMJxigy96cxeHGNwpjgP-CMO462GAEcZk7mMP1eXgJgsOf4ZwPyXAYcCfzJifoyfe9BlePNwn6OvF-ZfF--rqw_Jy8faqspIJUjnGO9N5zwR3VBJoQVpqV41yCkxriWuaTlHOlG9XRK06sJTz1vnOGFoAlJ-gV3tu-cntBHnUm5At9L0ZIE5Z02KBCNpQWartvmpTzDmB1zcpbEzalZKe7eq1nsXpWaKe7eq_dvW2jL582DKtNuAOg_90lsKbfeF36GH332C9eHd2NscCqPaAkIv7A8CkX7pRXEn9_Xqpl4zwjv8oDP4HoHaXZg</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Abbasi, Esmail</creator><creator>Nassiri-Asl, Marjan</creator><creator>Shafeei, Mahsa</creator><creator>Sheikhi, Mehdi</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole-Induced Seizure in Rats</title><author>Abbasi, Esmail ; Nassiri-Asl, Marjan ; Shafeei, Mahsa ; Sheikhi, Mehdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5240-d239a9ff243d150e8e5c1cb67d7ea8c0d66971327f8b07b9ec1338df9aa152413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Apigenin - pharmacology</topic><topic>Apigenin - therapeutic use</topic><topic>flavonoids</topic><topic>Flumazenil - pharmacology</topic><topic>GABA Modulators - pharmacology</topic><topic>GABAA</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Male</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Pennisetum - chemistry</topic><topic>Pentylenetetrazole</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>seizure</topic><topic>Seizures - chemically induced</topic><topic>Seizures - drug therapy</topic><topic>vitexin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abbasi, Esmail</creatorcontrib><creatorcontrib>Nassiri-Asl, Marjan</creatorcontrib><creatorcontrib>Shafeei, Mahsa</creatorcontrib><creatorcontrib>Sheikhi, Mehdi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical biology & drug design</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbasi, Esmail</au><au>Nassiri-Asl, Marjan</au><au>Shafeei, Mahsa</au><au>Sheikhi, Mehdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole-Induced Seizure in Rats</atitle><jtitle>Chemical biology & drug design</jtitle><addtitle>Chem Biol Drug Des</addtitle><date>2012-08</date><risdate>2012</risdate><volume>80</volume><issue>2</issue><spage>274</spage><epage>278</epage><pages>274-278</pages><issn>1747-0277</issn><eissn>1747-0285</eissn><abstract>Flavonoids are important constituents of food and beverages and have several neuropharmacological activities. Many of these compounds are ligands for γ‐aminobutyric acid type A receptors in the central nervous system. This study aimed to investigate the anticonvulsant effects of intracerebroventricularly administered vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants, in rats treated with pentylenetetrazole (90 mg/kg, intraperitoneally) and to clarify the underlying mechanism. Vitexin (100 and 200 μm, i.c.v) affected minimal clonic seizures and generalized tonic–clonic seizures induced by pentylenetetrazole by increasing the seizure onset time. Pretreatment with flumazenil suppressed the anticonvulsant effects of vitexin during the onset of both the seizures. These results indicate that vitexin has anticonvulsant effects in the brain, possibly through interaction at the benzodiazepine site of the γ‐aminobutyric acid type A receptor complex.
Vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants. The anticonvulsant effects of vitexin were investigated in rats. Vitexin affected minimal clonic seizures and generalized toni–clonic seizures induced by pentylenetetrazole.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22554436</pmid><doi>10.1111/j.1747-0285.2012.01400.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1747-0277 |
| ispartof | Chemical biology & drug design, 2012-08, Vol.80 (2), p.274-278 |
| issn | 1747-0277 1747-0285 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1027041615 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Apigenin - pharmacology Apigenin - therapeutic use flavonoids Flumazenil - pharmacology GABA Modulators - pharmacology GABAA gamma-Aminobutyric Acid - metabolism Male Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Pennisetum - chemistry Pentylenetetrazole Rats Rats, Wistar seizure Seizures - chemically induced Seizures - drug therapy vitexin |
| title | Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole-Induced Seizure in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T05%3A30%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuroprotective%20Effects%20of%20Vitexin,%20a%20Flavonoid,%20on%20Pentylenetetrazole-Induced%20Seizure%20in%20Rats&rft.jtitle=Chemical%20biology%20&%20drug%20design&rft.au=Abbasi,%20Esmail&rft.date=2012-08&rft.volume=80&rft.issue=2&rft.spage=274&rft.epage=278&rft.pages=274-278&rft.issn=1747-0277&rft.eissn=1747-0285&rft_id=info:doi/10.1111/j.1747-0285.2012.01400.x&rft_dat=%3Cproquest_cross%3E1027041615%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1027041615&rft_id=info:pmid/22554436&rfr_iscdi=true |