Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation
Purpose: To quantify liver T1 relaxation times before and after oxygen inhalation in patients with and without liver cirrhosis using a 3 Tesla (T) MRI. Materials and Methods: Institutional Review Board approval and written informed consent were obtained. Ninety‐two noncirrhotic patients and 87 patie...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2012-08, Vol.36 (2), p.405-410 |
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| creator | Kim, Kyung Ah Park, Mi-Suk Kim, In-Seong Kiefer, Berthold Chung, Woo-Suk Kim, Myeong-Jin Kim, Ki Whang |
| description | Purpose:
To quantify liver T1 relaxation times before and after oxygen inhalation in patients with and without liver cirrhosis using a 3 Tesla (T) MRI.
Materials and Methods:
Institutional Review Board approval and written informed consent were obtained. Ninety‐two noncirrhotic patients and 87 patients with hepatitis B viral liver cirrhosis (72 Child‐Pugh class A and 15 Child‐Pugh class B or C) underwent MRI with a 3.0T system before and after the supply of 100% oxygen at a rate of 15 L/min by means of a nonrebreather ventilation mask for 3 min. T1 maps were acquired using three‐dimensional spoiled gradient echo sequences with two different flip angles (2° and 14°) and a fixed TR/TE (2.54 ms/0.95 ms). Liver T1 values were obtained using a T1 processing tool (MapIT software). The mean baseline T1 values of three groups (control, Child‐Pugh class A, and Child‐Pugh class B/C) were compared using an analysis of variance test. Liver T1 value before and after oxygenation was compared using a paired t‐test for each group.
Results:
The baseline liver T1 value was significantly higher in the control group (941 ± 136 ms) than in Child‐Pugh A (858 ± 143 ms) and Child‐Pugh B/C (783 ± 164 ms) group (P < 0.001 and P < 0.0001). The reduction in the liver T1 value after oxygen inhalation was significant in the control group (P = 0.012) but not significant in Child‐Pugh class A (P = 0.079) and Child‐Pugh class B/C (P = 0.752).
Conclusion:
The baseline liver T1 relaxation time was significantly different between the patients with and without liver cirrhosis. The shortening effect of oxygen on the liver T1 value was significant in the control group but not in the cirrhotic patients. J. Magn. Reson. Imaging 2012;36:405–410. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmri.23620 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1027041098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1027041098</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3670-e57e024ae9590e8a24c361d321ed8b5f25d939ac02c47ad99efcace6609355d83</originalsourceid><addsrcrecordid>eNp9kE1P3DAURS3UqlDopj-g8rKqFPpsx0m8pKN2ykeLqCgsLU_ywhichNoOM_Pv8RBg2dW7ejr3LC4hHxkcMgD-9bbz9pCLgsMO2WOS84zLqniTMkiRsQrKXfI-hFsAUCqX78gu50LxSsg9sroYTR9tNNE-IMUH48YUh54OLXXp5WltvV8OwQY6Btvf0EtGPTqznrBoO6QrG5dU0IjBGfrrzzFdYDt4pKZvqGljkgzrzQ321PZL456KB-Rta1zAD893n_z98f1y9jM7O58fz47OsloUJWQoSwSeG1RSAVaG5-nPGsEZNtVCtlw2SihTA6_z0jRKYVubGosClJCyqcQ--Tx57_3wb8QQdWdDjc6ZHocxaAa8hJyB2qJfJrT2QwgeW33vbWf8JkF6O7TeDq2fhk7wp2fvuOiweUVflk0Am4CVdbj5j0qfpMVepNnUsSHi-rVj_J0uSlFKff17rmfz06vTa3mhv4lHR4WZKg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1027041098</pqid></control><display><type>article</type><title>Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kim, Kyung Ah ; Park, Mi-Suk ; Kim, In-Seong ; Kiefer, Berthold ; Chung, Woo-Suk ; Kim, Myeong-Jin ; Kim, Ki Whang</creator><creatorcontrib>Kim, Kyung Ah ; Park, Mi-Suk ; Kim, In-Seong ; Kiefer, Berthold ; Chung, Woo-Suk ; Kim, Myeong-Jin ; Kim, Ki Whang</creatorcontrib><description>Purpose:
To quantify liver T1 relaxation times before and after oxygen inhalation in patients with and without liver cirrhosis using a 3 Tesla (T) MRI.
Materials and Methods:
Institutional Review Board approval and written informed consent were obtained. Ninety‐two noncirrhotic patients and 87 patients with hepatitis B viral liver cirrhosis (72 Child‐Pugh class A and 15 Child‐Pugh class B or C) underwent MRI with a 3.0T system before and after the supply of 100% oxygen at a rate of 15 L/min by means of a nonrebreather ventilation mask for 3 min. T1 maps were acquired using three‐dimensional spoiled gradient echo sequences with two different flip angles (2° and 14°) and a fixed TR/TE (2.54 ms/0.95 ms). Liver T1 values were obtained using a T1 processing tool (MapIT software). The mean baseline T1 values of three groups (control, Child‐Pugh class A, and Child‐Pugh class B/C) were compared using an analysis of variance test. Liver T1 value before and after oxygenation was compared using a paired t‐test for each group.
Results:
The baseline liver T1 value was significantly higher in the control group (941 ± 136 ms) than in Child‐Pugh A (858 ± 143 ms) and Child‐Pugh B/C (783 ± 164 ms) group (P < 0.001 and P < 0.0001). The reduction in the liver T1 value after oxygen inhalation was significant in the control group (P = 0.012) but not significant in Child‐Pugh class A (P = 0.079) and Child‐Pugh class B/C (P = 0.752).
Conclusion:
The baseline liver T1 relaxation time was significantly different between the patients with and without liver cirrhosis. The shortening effect of oxygen on the liver T1 value was significant in the control group but not in the cirrhotic patients. J. Magn. Reson. Imaging 2012;36:405–410. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.23620</identifier><identifier>PMID: 22392835</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Administration, Inhalation ; Adult ; Aged ; Contrast Media - administration & dosage ; Female ; Humans ; Liver - drug effects ; Liver - physiopathology ; liver cirrhosis ; Liver Cirrhosis - pathology ; Liver Cirrhosis - physiopathology ; magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Oxygen - administration & dosage ; oxygenation ; T1 relaxation time</subject><ispartof>Journal of magnetic resonance imaging, 2012-08, Vol.36 (2), p.405-410</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3670-e57e024ae9590e8a24c361d321ed8b5f25d939ac02c47ad99efcace6609355d83</citedby><cites>FETCH-LOGICAL-c3670-e57e024ae9590e8a24c361d321ed8b5f25d939ac02c47ad99efcace6609355d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.23620$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.23620$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22392835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Kyung Ah</creatorcontrib><creatorcontrib>Park, Mi-Suk</creatorcontrib><creatorcontrib>Kim, In-Seong</creatorcontrib><creatorcontrib>Kiefer, Berthold</creatorcontrib><creatorcontrib>Chung, Woo-Suk</creatorcontrib><creatorcontrib>Kim, Myeong-Jin</creatorcontrib><creatorcontrib>Kim, Ki Whang</creatorcontrib><title>Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose:
To quantify liver T1 relaxation times before and after oxygen inhalation in patients with and without liver cirrhosis using a 3 Tesla (T) MRI.
Materials and Methods:
Institutional Review Board approval and written informed consent were obtained. Ninety‐two noncirrhotic patients and 87 patients with hepatitis B viral liver cirrhosis (72 Child‐Pugh class A and 15 Child‐Pugh class B or C) underwent MRI with a 3.0T system before and after the supply of 100% oxygen at a rate of 15 L/min by means of a nonrebreather ventilation mask for 3 min. T1 maps were acquired using three‐dimensional spoiled gradient echo sequences with two different flip angles (2° and 14°) and a fixed TR/TE (2.54 ms/0.95 ms). Liver T1 values were obtained using a T1 processing tool (MapIT software). The mean baseline T1 values of three groups (control, Child‐Pugh class A, and Child‐Pugh class B/C) were compared using an analysis of variance test. Liver T1 value before and after oxygenation was compared using a paired t‐test for each group.
Results:
The baseline liver T1 value was significantly higher in the control group (941 ± 136 ms) than in Child‐Pugh A (858 ± 143 ms) and Child‐Pugh B/C (783 ± 164 ms) group (P < 0.001 and P < 0.0001). The reduction in the liver T1 value after oxygen inhalation was significant in the control group (P = 0.012) but not significant in Child‐Pugh class A (P = 0.079) and Child‐Pugh class B/C (P = 0.752).
Conclusion:
The baseline liver T1 relaxation time was significantly different between the patients with and without liver cirrhosis. The shortening effect of oxygen on the liver T1 value was significant in the control group but not in the cirrhotic patients. J. Magn. Reson. Imaging 2012;36:405–410. © 2012 Wiley Periodicals, Inc.</description><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Aged</subject><subject>Contrast Media - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - drug effects</subject><subject>Liver - physiopathology</subject><subject>liver cirrhosis</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen - administration & dosage</subject><subject>oxygenation</subject><subject>T1 relaxation time</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAURS3UqlDopj-g8rKqFPpsx0m8pKN2ykeLqCgsLU_ywhichNoOM_Pv8RBg2dW7ejr3LC4hHxkcMgD-9bbz9pCLgsMO2WOS84zLqniTMkiRsQrKXfI-hFsAUCqX78gu50LxSsg9sroYTR9tNNE-IMUH48YUh54OLXXp5WltvV8OwQY6Btvf0EtGPTqznrBoO6QrG5dU0IjBGfrrzzFdYDt4pKZvqGljkgzrzQ321PZL456KB-Rta1zAD893n_z98f1y9jM7O58fz47OsloUJWQoSwSeG1RSAVaG5-nPGsEZNtVCtlw2SihTA6_z0jRKYVubGosClJCyqcQ--Tx57_3wb8QQdWdDjc6ZHocxaAa8hJyB2qJfJrT2QwgeW33vbWf8JkF6O7TeDq2fhk7wp2fvuOiweUVflk0Am4CVdbj5j0qfpMVepNnUsSHi-rVj_J0uSlFKff17rmfz06vTa3mhv4lHR4WZKg</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Kim, Kyung Ah</creator><creator>Park, Mi-Suk</creator><creator>Kim, In-Seong</creator><creator>Kiefer, Berthold</creator><creator>Chung, Woo-Suk</creator><creator>Kim, Myeong-Jin</creator><creator>Kim, Ki Whang</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation</title><author>Kim, Kyung Ah ; Park, Mi-Suk ; Kim, In-Seong ; Kiefer, Berthold ; Chung, Woo-Suk ; Kim, Myeong-Jin ; Kim, Ki Whang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3670-e57e024ae9590e8a24c361d321ed8b5f25d939ac02c47ad99efcace6609355d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Inhalation</topic><topic>Adult</topic><topic>Aged</topic><topic>Contrast Media - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Liver - drug effects</topic><topic>Liver - physiopathology</topic><topic>liver cirrhosis</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen - administration & dosage</topic><topic>oxygenation</topic><topic>T1 relaxation time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Kyung Ah</creatorcontrib><creatorcontrib>Park, Mi-Suk</creatorcontrib><creatorcontrib>Kim, In-Seong</creatorcontrib><creatorcontrib>Kiefer, Berthold</creatorcontrib><creatorcontrib>Chung, Woo-Suk</creatorcontrib><creatorcontrib>Kim, Myeong-Jin</creatorcontrib><creatorcontrib>Kim, Ki Whang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Kyung Ah</au><au>Park, Mi-Suk</au><au>Kim, In-Seong</au><au>Kiefer, Berthold</au><au>Chung, Woo-Suk</au><au>Kim, Myeong-Jin</au><au>Kim, Ki Whang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2012-08</date><risdate>2012</risdate><volume>36</volume><issue>2</issue><spage>405</spage><epage>410</epage><pages>405-410</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose:
To quantify liver T1 relaxation times before and after oxygen inhalation in patients with and without liver cirrhosis using a 3 Tesla (T) MRI.
Materials and Methods:
Institutional Review Board approval and written informed consent were obtained. Ninety‐two noncirrhotic patients and 87 patients with hepatitis B viral liver cirrhosis (72 Child‐Pugh class A and 15 Child‐Pugh class B or C) underwent MRI with a 3.0T system before and after the supply of 100% oxygen at a rate of 15 L/min by means of a nonrebreather ventilation mask for 3 min. T1 maps were acquired using three‐dimensional spoiled gradient echo sequences with two different flip angles (2° and 14°) and a fixed TR/TE (2.54 ms/0.95 ms). Liver T1 values were obtained using a T1 processing tool (MapIT software). The mean baseline T1 values of three groups (control, Child‐Pugh class A, and Child‐Pugh class B/C) were compared using an analysis of variance test. Liver T1 value before and after oxygenation was compared using a paired t‐test for each group.
Results:
The baseline liver T1 value was significantly higher in the control group (941 ± 136 ms) than in Child‐Pugh A (858 ± 143 ms) and Child‐Pugh B/C (783 ± 164 ms) group (P < 0.001 and P < 0.0001). The reduction in the liver T1 value after oxygen inhalation was significant in the control group (P = 0.012) but not significant in Child‐Pugh class A (P = 0.079) and Child‐Pugh class B/C (P = 0.752).
Conclusion:
The baseline liver T1 relaxation time was significantly different between the patients with and without liver cirrhosis. The shortening effect of oxygen on the liver T1 value was significant in the control group but not in the cirrhotic patients. J. Magn. Reson. Imaging 2012;36:405–410. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22392835</pmid><doi>10.1002/jmri.23620</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Inhalation Adult Aged Contrast Media - administration & dosage Female Humans Liver - drug effects Liver - physiopathology liver cirrhosis Liver Cirrhosis - pathology Liver Cirrhosis - physiopathology magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Oxygen - administration & dosage oxygenation T1 relaxation time |
| title | Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation |
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