Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence
Background & Aims Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HCC was assessed using a novel immuno-inhibition method. Methods Among patients with cirrhosis caused b...
Gespeichert in:
| Veröffentlicht in: | Journal of hepatology 2012-08, Vol.57 (2), p.330-336 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 336 |
|---|---|
| container_issue | 2 |
| container_start_page | 330 |
| container_title | Journal of hepatology |
| container_volume | 57 |
| creator | Soroida, Yoko Ohkawa, Ryunosuke Nakagawa, Hayato Satoh, Yumiko Yoshida, Haruhiko Kinoshita, Hiroto Tateishi, Ryosuke Masuzaki, Ryota Enooku, Kenichiro Shiina, Shuichiro Sato, Takahisa Obi, Shuntaro Hoshino, Tadashi Nagatomo, Ritsuko Okubo, Shigeo Yokota, Hiromitsu Koike, Kazuhiko Yatomi, Yutaka Ikeda, Hitoshi |
| description | Background & Aims Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HCC was assessed using a novel immuno-inhibition method. Methods Among patients with cirrhosis caused by hepatitis B or C virus, 147 patients with HCC (12 with the first occurrence and 135 with recurrence) and 92 patients without HCC were enrolled. Results Serum MtCK activity was higher in cirrhotic patients with HCC than in those without HCC or healthy subjects. Elevated serum MtCK activity in HCC patients decreased after radiofrequency ablation. In case of prediction of HCC, MtCK had a sensitivity of 62.6% and a specificity of 70.7% at a cut-off point of 8.0 U/L, with an area under the receiver operating curve of 0.722 vs. 0.713 for alpha-fetoprotein (AFP) and 0.764 for des-gamma-carboxy prothrombin (DCP). Among the HCC patients, serum MtCK activity was elevated in 52.9% individuals with serum AFP level |
| doi_str_mv | 10.1016/j.jhep.2012.03.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1026867506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S016882781200267X</els_id><sourcerecordid>1026867506</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-86dcffa65b2b8d08d2935450370dd5b5b2553380045950717f708f28386b90ec3</originalsourceid><addsrcrecordid>eNp9kk2LFDEQhhtR3HH1D3iQXAQvM1aS_siACLL4sbDgQQVvIZ1UM-ntTsake6X9B_5rq5lRwYOnguJ5K5X3raJ4ymHHgdcv-11_wONOABc7kDsq94oNrwG2UJf8frEhSG2VaNRF8SjnHgAk7MuHxYUQleCy3G-Kn9fBJjQZHTN28nd-WljsWMY0j2z0U7SHGFzyZmA-Rww_lhFXYBVNPiC79YHUzAdGuxjicRjmwSRmTbI-xNEwansMU2bHhC6OJAjTsLDvfjqwhHZOCYPFx8WDzgwZn5zrZfHl3dvPVx-2Nx_fX1-9udnasuTTVtXOdp2pq1a0yoFyYi-rsgLZgHNVS-2qklIBlNW-goY3XQOqE0qqut0DWnlZvDjNPab4bcY86dHndWsTMM5ZcxC1qpsKakLFCbUp5pyw08fkR5MWgvQage71GoFeI9AgNRUSPTvPn9sR3R_Jb88JeH4GTLZm6JIJ1ue_XM1L-kxD3KsTh-TGnceks_WrU86Ta5N20f9_j9f_yO3gg6cXb3HB3Mc5BfJZc51Joz-tx7LeChdADjRf5S-HWbwf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1026867506</pqid></control><display><type>article</type><title>Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Soroida, Yoko ; Ohkawa, Ryunosuke ; Nakagawa, Hayato ; Satoh, Yumiko ; Yoshida, Haruhiko ; Kinoshita, Hiroto ; Tateishi, Ryosuke ; Masuzaki, Ryota ; Enooku, Kenichiro ; Shiina, Shuichiro ; Sato, Takahisa ; Obi, Shuntaro ; Hoshino, Tadashi ; Nagatomo, Ritsuko ; Okubo, Shigeo ; Yokota, Hiromitsu ; Koike, Kazuhiko ; Yatomi, Yutaka ; Ikeda, Hitoshi</creator><creatorcontrib>Soroida, Yoko ; Ohkawa, Ryunosuke ; Nakagawa, Hayato ; Satoh, Yumiko ; Yoshida, Haruhiko ; Kinoshita, Hiroto ; Tateishi, Ryosuke ; Masuzaki, Ryota ; Enooku, Kenichiro ; Shiina, Shuichiro ; Sato, Takahisa ; Obi, Shuntaro ; Hoshino, Tadashi ; Nagatomo, Ritsuko ; Okubo, Shigeo ; Yokota, Hiromitsu ; Koike, Kazuhiko ; Yatomi, Yutaka ; Ikeda, Hitoshi</creatorcontrib><description>Background & Aims Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HCC was assessed using a novel immuno-inhibition method. Methods Among patients with cirrhosis caused by hepatitis B or C virus, 147 patients with HCC (12 with the first occurrence and 135 with recurrence) and 92 patients without HCC were enrolled. Results Serum MtCK activity was higher in cirrhotic patients with HCC than in those without HCC or healthy subjects. Elevated serum MtCK activity in HCC patients decreased after radiofrequency ablation. In case of prediction of HCC, MtCK had a sensitivity of 62.6% and a specificity of 70.7% at a cut-off point of 8.0 U/L, with an area under the receiver operating curve of 0.722 vs. 0.713 for alpha-fetoprotein (AFP) and 0.764 for des-gamma-carboxy prothrombin (DCP). Among the HCC patients, serum MtCK activity was elevated in 52.9% individuals with serum AFP level <20 ng/ml and 63.2% individuals with serum DCP level <40 mAu/ml. Even in patients with a single HCC ⩽2 cm, the sensitivity of serum MtCK activity for the prediction of HCC was 64.4%, which was comparable to the overall sensitivity. This increased activity was due to an increase in ubiquitous MtCK, not sarcomeric MtCK, and the enhanced mRNA expression of ubiquitous MtCK was observed in cell lines originating from HCCs in contrast to healthy liver tissues. Conclusions Serum MtCK activity merits consideration as a novel marker for HCC to be further tested as for its diagnostic and prognostic power.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2012.03.012</identifier><identifier>PMID: 22521349</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Aged ; Alpha-fetoprotein ; alpha-Fetoproteins - analysis ; Biological and medical sciences ; Biomarkers - blood ; Carcinoma, Hepatocellular - enzymology ; Creatine Kinase, Mitochondrial Form - blood ; Creatine Kinase, Mitochondrial Form - genetics ; Des-gamma-carboxy prothrombin ; Female ; Gastroenterology and Hepatology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatocellular carcinoma ; Humans ; Isoenzymes - blood ; Liver Neoplasms - enzymology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Mitochondrial isoenzyme of creatine kinase ; Neoplasm Recurrence, Local - enzymology ; Protein Precursors - blood ; Prothrombin ; RNA, Messenger - analysis ; Tumors</subject><ispartof>Journal of hepatology, 2012-08, Vol.57 (2), p.330-336</ispartof><rights>European Association for the Study of the Liver</rights><rights>2012 European Association for the Study of the Liver</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-86dcffa65b2b8d08d2935450370dd5b5b2553380045950717f708f28386b90ec3</citedby><cites>FETCH-LOGICAL-c441t-86dcffa65b2b8d08d2935450370dd5b5b2553380045950717f708f28386b90ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhep.2012.03.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26143707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22521349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soroida, Yoko</creatorcontrib><creatorcontrib>Ohkawa, Ryunosuke</creatorcontrib><creatorcontrib>Nakagawa, Hayato</creatorcontrib><creatorcontrib>Satoh, Yumiko</creatorcontrib><creatorcontrib>Yoshida, Haruhiko</creatorcontrib><creatorcontrib>Kinoshita, Hiroto</creatorcontrib><creatorcontrib>Tateishi, Ryosuke</creatorcontrib><creatorcontrib>Masuzaki, Ryota</creatorcontrib><creatorcontrib>Enooku, Kenichiro</creatorcontrib><creatorcontrib>Shiina, Shuichiro</creatorcontrib><creatorcontrib>Sato, Takahisa</creatorcontrib><creatorcontrib>Obi, Shuntaro</creatorcontrib><creatorcontrib>Hoshino, Tadashi</creatorcontrib><creatorcontrib>Nagatomo, Ritsuko</creatorcontrib><creatorcontrib>Okubo, Shigeo</creatorcontrib><creatorcontrib>Yokota, Hiromitsu</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><creatorcontrib>Yatomi, Yutaka</creatorcontrib><creatorcontrib>Ikeda, Hitoshi</creatorcontrib><title>Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Background & Aims Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HCC was assessed using a novel immuno-inhibition method. Methods Among patients with cirrhosis caused by hepatitis B or C virus, 147 patients with HCC (12 with the first occurrence and 135 with recurrence) and 92 patients without HCC were enrolled. Results Serum MtCK activity was higher in cirrhotic patients with HCC than in those without HCC or healthy subjects. Elevated serum MtCK activity in HCC patients decreased after radiofrequency ablation. In case of prediction of HCC, MtCK had a sensitivity of 62.6% and a specificity of 70.7% at a cut-off point of 8.0 U/L, with an area under the receiver operating curve of 0.722 vs. 0.713 for alpha-fetoprotein (AFP) and 0.764 for des-gamma-carboxy prothrombin (DCP). Among the HCC patients, serum MtCK activity was elevated in 52.9% individuals with serum AFP level <20 ng/ml and 63.2% individuals with serum DCP level <40 mAu/ml. Even in patients with a single HCC ⩽2 cm, the sensitivity of serum MtCK activity for the prediction of HCC was 64.4%, which was comparable to the overall sensitivity. This increased activity was due to an increase in ubiquitous MtCK, not sarcomeric MtCK, and the enhanced mRNA expression of ubiquitous MtCK was observed in cell lines originating from HCCs in contrast to healthy liver tissues. Conclusions Serum MtCK activity merits consideration as a novel marker for HCC to be further tested as for its diagnostic and prognostic power.</description><subject>Aged</subject><subject>Alpha-fetoprotein</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Carcinoma, Hepatocellular - enzymology</subject><subject>Creatine Kinase, Mitochondrial Form - blood</subject><subject>Creatine Kinase, Mitochondrial Form - genetics</subject><subject>Des-gamma-carboxy prothrombin</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Isoenzymes - blood</subject><subject>Liver Neoplasms - enzymology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitochondrial isoenzyme of creatine kinase</subject><subject>Neoplasm Recurrence, Local - enzymology</subject><subject>Protein Precursors - blood</subject><subject>Prothrombin</subject><subject>RNA, Messenger - analysis</subject><subject>Tumors</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2LFDEQhhtR3HH1D3iQXAQvM1aS_siACLL4sbDgQQVvIZ1UM-ntTsake6X9B_5rq5lRwYOnguJ5K5X3raJ4ymHHgdcv-11_wONOABc7kDsq94oNrwG2UJf8frEhSG2VaNRF8SjnHgAk7MuHxYUQleCy3G-Kn9fBJjQZHTN28nd-WljsWMY0j2z0U7SHGFzyZmA-Rww_lhFXYBVNPiC79YHUzAdGuxjicRjmwSRmTbI-xNEwansMU2bHhC6OJAjTsLDvfjqwhHZOCYPFx8WDzgwZn5zrZfHl3dvPVx-2Nx_fX1-9udnasuTTVtXOdp2pq1a0yoFyYi-rsgLZgHNVS-2qklIBlNW-goY3XQOqE0qqut0DWnlZvDjNPab4bcY86dHndWsTMM5ZcxC1qpsKakLFCbUp5pyw08fkR5MWgvQage71GoFeI9AgNRUSPTvPn9sR3R_Jb88JeH4GTLZm6JIJ1ue_XM1L-kxD3KsTh-TGnceks_WrU86Ta5N20f9_j9f_yO3gg6cXb3HB3Mc5BfJZc51Joz-tx7LeChdADjRf5S-HWbwf</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Soroida, Yoko</creator><creator>Ohkawa, Ryunosuke</creator><creator>Nakagawa, Hayato</creator><creator>Satoh, Yumiko</creator><creator>Yoshida, Haruhiko</creator><creator>Kinoshita, Hiroto</creator><creator>Tateishi, Ryosuke</creator><creator>Masuzaki, Ryota</creator><creator>Enooku, Kenichiro</creator><creator>Shiina, Shuichiro</creator><creator>Sato, Takahisa</creator><creator>Obi, Shuntaro</creator><creator>Hoshino, Tadashi</creator><creator>Nagatomo, Ritsuko</creator><creator>Okubo, Shigeo</creator><creator>Yokota, Hiromitsu</creator><creator>Koike, Kazuhiko</creator><creator>Yatomi, Yutaka</creator><creator>Ikeda, Hitoshi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence</title><author>Soroida, Yoko ; Ohkawa, Ryunosuke ; Nakagawa, Hayato ; Satoh, Yumiko ; Yoshida, Haruhiko ; Kinoshita, Hiroto ; Tateishi, Ryosuke ; Masuzaki, Ryota ; Enooku, Kenichiro ; Shiina, Shuichiro ; Sato, Takahisa ; Obi, Shuntaro ; Hoshino, Tadashi ; Nagatomo, Ritsuko ; Okubo, Shigeo ; Yokota, Hiromitsu ; Koike, Kazuhiko ; Yatomi, Yutaka ; Ikeda, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-86dcffa65b2b8d08d2935450370dd5b5b2553380045950717f708f28386b90ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Alpha-fetoprotein</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Carcinoma, Hepatocellular - enzymology</topic><topic>Creatine Kinase, Mitochondrial Form - blood</topic><topic>Creatine Kinase, Mitochondrial Form - genetics</topic><topic>Des-gamma-carboxy prothrombin</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Isoenzymes - blood</topic><topic>Liver Neoplasms - enzymology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitochondrial isoenzyme of creatine kinase</topic><topic>Neoplasm Recurrence, Local - enzymology</topic><topic>Protein Precursors - blood</topic><topic>Prothrombin</topic><topic>RNA, Messenger - analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soroida, Yoko</creatorcontrib><creatorcontrib>Ohkawa, Ryunosuke</creatorcontrib><creatorcontrib>Nakagawa, Hayato</creatorcontrib><creatorcontrib>Satoh, Yumiko</creatorcontrib><creatorcontrib>Yoshida, Haruhiko</creatorcontrib><creatorcontrib>Kinoshita, Hiroto</creatorcontrib><creatorcontrib>Tateishi, Ryosuke</creatorcontrib><creatorcontrib>Masuzaki, Ryota</creatorcontrib><creatorcontrib>Enooku, Kenichiro</creatorcontrib><creatorcontrib>Shiina, Shuichiro</creatorcontrib><creatorcontrib>Sato, Takahisa</creatorcontrib><creatorcontrib>Obi, Shuntaro</creatorcontrib><creatorcontrib>Hoshino, Tadashi</creatorcontrib><creatorcontrib>Nagatomo, Ritsuko</creatorcontrib><creatorcontrib>Okubo, Shigeo</creatorcontrib><creatorcontrib>Yokota, Hiromitsu</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><creatorcontrib>Yatomi, Yutaka</creatorcontrib><creatorcontrib>Ikeda, Hitoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soroida, Yoko</au><au>Ohkawa, Ryunosuke</au><au>Nakagawa, Hayato</au><au>Satoh, Yumiko</au><au>Yoshida, Haruhiko</au><au>Kinoshita, Hiroto</au><au>Tateishi, Ryosuke</au><au>Masuzaki, Ryota</au><au>Enooku, Kenichiro</au><au>Shiina, Shuichiro</au><au>Sato, Takahisa</au><au>Obi, Shuntaro</au><au>Hoshino, Tadashi</au><au>Nagatomo, Ritsuko</au><au>Okubo, Shigeo</au><au>Yokota, Hiromitsu</au><au>Koike, Kazuhiko</au><au>Yatomi, Yutaka</au><au>Ikeda, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>57</volume><issue>2</issue><spage>330</spage><epage>336</epage><pages>330-336</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Background & Aims Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HCC was assessed using a novel immuno-inhibition method. Methods Among patients with cirrhosis caused by hepatitis B or C virus, 147 patients with HCC (12 with the first occurrence and 135 with recurrence) and 92 patients without HCC were enrolled. Results Serum MtCK activity was higher in cirrhotic patients with HCC than in those without HCC or healthy subjects. Elevated serum MtCK activity in HCC patients decreased after radiofrequency ablation. In case of prediction of HCC, MtCK had a sensitivity of 62.6% and a specificity of 70.7% at a cut-off point of 8.0 U/L, with an area under the receiver operating curve of 0.722 vs. 0.713 for alpha-fetoprotein (AFP) and 0.764 for des-gamma-carboxy prothrombin (DCP). Among the HCC patients, serum MtCK activity was elevated in 52.9% individuals with serum AFP level <20 ng/ml and 63.2% individuals with serum DCP level <40 mAu/ml. Even in patients with a single HCC ⩽2 cm, the sensitivity of serum MtCK activity for the prediction of HCC was 64.4%, which was comparable to the overall sensitivity. This increased activity was due to an increase in ubiquitous MtCK, not sarcomeric MtCK, and the enhanced mRNA expression of ubiquitous MtCK was observed in cell lines originating from HCCs in contrast to healthy liver tissues. Conclusions Serum MtCK activity merits consideration as a novel marker for HCC to be further tested as for its diagnostic and prognostic power.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>22521349</pmid><doi>10.1016/j.jhep.2012.03.012</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 2012-08, Vol.57 (2), p.330-336 |
| issn | 0168-8278 1600-0641 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1026867506 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Alpha-fetoprotein alpha-Fetoproteins - analysis Biological and medical sciences Biomarkers - blood Carcinoma, Hepatocellular - enzymology Creatine Kinase, Mitochondrial Form - blood Creatine Kinase, Mitochondrial Form - genetics Des-gamma-carboxy prothrombin Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Hepatocellular carcinoma Humans Isoenzymes - blood Liver Neoplasms - enzymology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Mitochondrial isoenzyme of creatine kinase Neoplasm Recurrence, Local - enzymology Protein Precursors - blood Prothrombin RNA, Messenger - analysis Tumors |
| title | Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T03%3A41%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20activity%20of%20serum%20mitochondrial%20isoenzyme%20of%20creatine%20kinase%20in%20hepatocellular%20carcinoma%20patients%20predominantly%20with%20recurrence&rft.jtitle=Journal%20of%20hepatology&rft.au=Soroida,%20Yoko&rft.date=2012-08-01&rft.volume=57&rft.issue=2&rft.spage=330&rft.epage=336&rft.pages=330-336&rft.issn=0168-8278&rft.eissn=1600-0641&rft.coden=JOHEEC&rft_id=info:doi/10.1016/j.jhep.2012.03.012&rft_dat=%3Cproquest_cross%3E1026867506%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1026867506&rft_id=info:pmid/22521349&rft_els_id=S016882781200267X&rfr_iscdi=true |