LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/FoxO1 signaling

Background Pancreatic β cells are susceptible to fatty acid-induced apoptosis. The 17β-estradiol （E2） protects pancreatic βcells from apoptosis, mediated by the estrogen receptor-a （ERa）. The mRNA level and promoter activity of leukemia-related protein （LRP） 16 were significantly increased by E2 in...

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Veröffentlicht in:	Chinese medical journal 2012-05, Vol.125 (10), p.1695-1702
Hauptverfasser:	Li, Xiao-Jin, Guo, Qing-Hua, Wang, Xuan, Xue, Bing, Sun, Lian-Qing, Meng, Qu-Tao, Lu, Ju-Ming, Mu, Yi-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Blotting, Western Cell Line, Tumor Fatty Acids - pharmacology Forkhead Box Protein O1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism LRP16基因 Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects Signal Transduction - genetics Western印迹信号保护细胞凋亡细胞外信号调节激酶胰岛素分泌脂肪酸诱导凋亡
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