Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease
Human paraoxonase-1 (PON1) has also been described as a lactonase. Decreased PON1 lactonase activity was found to be a predictor of cardiovascular disease. Homocysteine thiolactonase activity may prevent proteins from homocysteinylation and is thought to be a protective factor against the progressio...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2012-07, Vol.27 (7), p.2866-2872 |
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| creator | SZTANEK, Ferenc SERES, Ildikó HARANGI, Mariann LOCSEY, Lajos PADRA, Janos PARAGH, György J. R ASZTALOS, László PARAGH, György |
| description | Human paraoxonase-1 (PON1) has also been described as a lactonase. Decreased PON1 lactonase activity was found to be a predictor of cardiovascular disease. Homocysteine thiolactonase activity may prevent proteins from homocysteinylation and is thought to be a protective factor against the progression of atherosclerosis. Previous studies have demonstrated decreased PON1 paraoxonase activity in hemodialyzed (HD) and renal transplant (TRX) patients; however, lactonase activity has not been investigated. We aimed to determine the paraoxonase and lactonase activities and to clarify the relationship between lactonase activity and a set of cardiovascular risk factors, such as homocysteine, cystatin C and asymmetric dimethylarginine (ADMA) levels, in HD and TRX patients and in healthy controls.
One hundred and eight HD and 78 TRX patients and 63 healthy controls were involved in the study. Paraoxonase and lactonase activities (paraoxon and gamma-thiobutyrolactone as substrates) were measured spectrophotometrically. ADMA level was determined with sandwich enzyme-linked immunosorbent assay.
Both HD and TRX patients had significantly lower lactonase activities compared to the control group (P |
| doi_str_mv | 10.1093/ndt/gfr753 |
| format | Article |
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One hundred and eight HD and 78 TRX patients and 63 healthy controls were involved in the study. Paraoxonase and lactonase activities (paraoxon and gamma-thiobutyrolactone as substrates) were measured spectrophotometrically. ADMA level was determined with sandwich enzyme-linked immunosorbent assay.
Both HD and TRX patients had significantly lower lactonase activities compared to the control group (P<0.05). Significantly lower paraoxonase activities were found in HD patients compared to the TRX group (P<0.05). Significant negative correlation was found between lactonase activity and ADMA level in the whole study population (P<0.001), while paraoxonase and lactonase activities showed significant positive correlation (P<0.001). Multiple regression analysis identified paraoxonase activity and homocysteine level as independent predictors of lactonase activity.
Lactonase activity is a potential new predictor of cardiovascular risk in renal failure. Measurement of lactonase activity is recommended in future studies on HD and TRX patients.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfr753</identifier><identifier>PMID: 22247228</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Aryldialkylphosphatase - blood ; Biological and medical sciences ; Biomarkers - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - enzymology ; Cardiovascular Diseases - etiology ; Case-Control Studies ; Emergency and intensive care: renal failure. Dialysis management ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - enzymology ; Kidney Failure, Chronic - therapy ; Kidney Transplantation - adverse effects ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Renal Dialysis - adverse effects ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system</subject><ispartof>Nephrology, dialysis, transplantation, 2012-07, Vol.27 (7), p.2866-2872</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-128916d24d570e2f696382c03db0ccdd14cfeede73595b25b212ad26a0ea1d283</citedby><cites>FETCH-LOGICAL-c353t-128916d24d570e2f696382c03db0ccdd14cfeede73595b25b212ad26a0ea1d283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26181022$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22247228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SZTANEK, Ferenc</creatorcontrib><creatorcontrib>SERES, Ildikó</creatorcontrib><creatorcontrib>HARANGI, Mariann</creatorcontrib><creatorcontrib>LOCSEY, Lajos</creatorcontrib><creatorcontrib>PADRA, Janos</creatorcontrib><creatorcontrib>PARAGH, György J. R</creatorcontrib><creatorcontrib>ASZTALOS, László</creatorcontrib><creatorcontrib>PARAGH, György</creatorcontrib><title>Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Human paraoxonase-1 (PON1) has also been described as a lactonase. Decreased PON1 lactonase activity was found to be a predictor of cardiovascular disease. Homocysteine thiolactonase activity may prevent proteins from homocysteinylation and is thought to be a protective factor against the progression of atherosclerosis. Previous studies have demonstrated decreased PON1 paraoxonase activity in hemodialyzed (HD) and renal transplant (TRX) patients; however, lactonase activity has not been investigated. We aimed to determine the paraoxonase and lactonase activities and to clarify the relationship between lactonase activity and a set of cardiovascular risk factors, such as homocysteine, cystatin C and asymmetric dimethylarginine (ADMA) levels, in HD and TRX patients and in healthy controls.
One hundred and eight HD and 78 TRX patients and 63 healthy controls were involved in the study. Paraoxonase and lactonase activities (paraoxon and gamma-thiobutyrolactone as substrates) were measured spectrophotometrically. ADMA level was determined with sandwich enzyme-linked immunosorbent assay.
Both HD and TRX patients had significantly lower lactonase activities compared to the control group (P<0.05). Significantly lower paraoxonase activities were found in HD patients compared to the TRX group (P<0.05). Significant negative correlation was found between lactonase activity and ADMA level in the whole study population (P<0.001), while paraoxonase and lactonase activities showed significant positive correlation (P<0.001). Multiple regression analysis identified paraoxonase activity and homocysteine level as independent predictors of lactonase activity.
Lactonase activity is a potential new predictor of cardiovascular risk in renal failure. Measurement of lactonase activity is recommended in future studies on HD and TRX patients.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Aryldialkylphosphatase - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - enzymology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Case-Control Studies</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - enzymology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Renal Dialysis - adverse effects</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkctOWzEQhq2qCFLaTR-g8qYSRTpgj3NuS0TLRULQRbs-mthzqMGxU9uJSB-GZ61DQitZsj3-5vfM_Ix9lOJEil6depNP78fY1uoNm8hpIypQXf2WTcqjrEQt-gP2LqUHIUQPbbvPDgBg2gJ0E_b8lXQkTGT4AiOGp-DLhUt-9P3uVn7hDnXehsrBrmxec-v5L5oHY9Gt_5Q89IZH8uh4jujTwqHPL3LZks_phJ9xH1bkuMZobFhh0kuHkc9smGN8pLhRJG-qlPGedlLGpk1V79neiC7Rh91-yH5efPtxflXd3F1en5_dVFrVKlcSul42BqambgXB2PSN6kALZWZCa2PkVI9EhlpV9_UMypKABhoUhNJApw7Z0VZ3EcPvJaU8zG3S5EovFJZpkAKarqllv0GPt6iOIaVI47CItjSyLtCw8WMofgxbPwr8aae7nM3J_ENfDSjA5x1QxoJuLBPUNv3nGtmVv0H9Bf7dlpA</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>SZTANEK, Ferenc</creator><creator>SERES, Ildikó</creator><creator>HARANGI, Mariann</creator><creator>LOCSEY, Lajos</creator><creator>PADRA, Janos</creator><creator>PARAGH, György J. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Aryldialkylphosphatase - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - enzymology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Case-Control Studies</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - enzymology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Renal Dialysis - adverse effects</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SZTANEK, Ferenc</creatorcontrib><creatorcontrib>SERES, Ildikó</creatorcontrib><creatorcontrib>HARANGI, Mariann</creatorcontrib><creatorcontrib>LOCSEY, Lajos</creatorcontrib><creatorcontrib>PADRA, Janos</creatorcontrib><creatorcontrib>PARAGH, György J. R</creatorcontrib><creatorcontrib>ASZTALOS, László</creatorcontrib><creatorcontrib>PARAGH, György</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SZTANEK, Ferenc</au><au>SERES, Ildikó</au><au>HARANGI, Mariann</au><au>LOCSEY, Lajos</au><au>PADRA, Janos</au><au>PARAGH, György J. R</au><au>ASZTALOS, László</au><au>PARAGH, György</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>27</volume><issue>7</issue><spage>2866</spage><epage>2872</epage><pages>2866-2872</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Human paraoxonase-1 (PON1) has also been described as a lactonase. Decreased PON1 lactonase activity was found to be a predictor of cardiovascular disease. Homocysteine thiolactonase activity may prevent proteins from homocysteinylation and is thought to be a protective factor against the progression of atherosclerosis. Previous studies have demonstrated decreased PON1 paraoxonase activity in hemodialyzed (HD) and renal transplant (TRX) patients; however, lactonase activity has not been investigated. We aimed to determine the paraoxonase and lactonase activities and to clarify the relationship between lactonase activity and a set of cardiovascular risk factors, such as homocysteine, cystatin C and asymmetric dimethylarginine (ADMA) levels, in HD and TRX patients and in healthy controls.
One hundred and eight HD and 78 TRX patients and 63 healthy controls were involved in the study. Paraoxonase and lactonase activities (paraoxon and gamma-thiobutyrolactone as substrates) were measured spectrophotometrically. ADMA level was determined with sandwich enzyme-linked immunosorbent assay.
Both HD and TRX patients had significantly lower lactonase activities compared to the control group (P<0.05). Significantly lower paraoxonase activities were found in HD patients compared to the TRX group (P<0.05). Significant negative correlation was found between lactonase activity and ADMA level in the whole study population (P<0.001), while paraoxonase and lactonase activities showed significant positive correlation (P<0.001). Multiple regression analysis identified paraoxonase activity and homocysteine level as independent predictors of lactonase activity.
Lactonase activity is a potential new predictor of cardiovascular risk in renal failure. Measurement of lactonase activity is recommended in future studies on HD and TRX patients.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22247228</pmid><doi>10.1093/ndt/gfr753</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nephrology, dialysis, transplantation, 2012-07, Vol.27 (7), p.2866-2872 |
| issn | 0931-0509 1460-2385 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Aryldialkylphosphatase - blood Biological and medical sciences Biomarkers - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - enzymology Cardiovascular Diseases - etiology Case-Control Studies Emergency and intensive care: renal failure. Dialysis management Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Intensive care medicine Kidney Failure, Chronic - complications Kidney Failure, Chronic - enzymology Kidney Failure, Chronic - therapy Kidney Transplantation - adverse effects Male Medical sciences Middle Aged Prognosis Renal Dialysis - adverse effects Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system |
| title | Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease |
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