Anti-Myeloma Effects of the Novel Anthracycline Derivative INNO-206

Doxorubicin has shown efficacy especially in combination treatment for the treatment of multiple myeloma; however, its side effects limit its use. INNO-206 is an albumin-binding prodrug of doxorubicin, which is released from albumin under acidic conditions. Because INNO-206 has not been previously e...

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Veröffentlicht in:	Clinical cancer research 2012-07, Vol.18 (14), p.3856-3867
Hauptverfasser:	SANCHEZ, Eric, MINGJIE LI, WANG, Cathy, NICHOLS, Cydney M, LI, Jennifer, CHEN, Haiming, BERENSON, James R
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - administration & dosage Animals Antibiotics, Antineoplastic - administration & dosage Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biological and medical sciences Boronic Acids - administration & dosage Bortezomib Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Hematologic and hematopoietic diseases Humans Hydrazones - administration & dosage Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mice Multiple Myeloma - drug therapy Neoplasms, Experimental - drug therapy Neovascularization, Pathologic - drug therapy Pharmacology. Drug treatments Pyrazines - administration & dosage
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