Real-time monitoring of breath ammonia during haemodialysis: use of ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques
The diffusion of high-performance analytical technology has opened prospects for breath diagnosis as a non-invasive diagnostic tool. In this study, ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques were used to analyse ammonia gas (NH3) in real-time in breath from p...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2012-07, Vol.27 (7), p.2945-2952 |
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| container_title | Nephrology, dialysis, transplantation |
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| creator | NERI, Giovanni LACQUANITI, Antonio RIZZO, Giuseppe DONATO, Nicola LATINO, Mariangela BUEMI, Michele |
| description | The diffusion of high-performance analytical technology has opened prospects for breath diagnosis as a non-invasive diagnostic tool. In this study, ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques were used to analyse ammonia gas (NH3) in real-time in breath from patients undergoing haemodialysis (HD) treatment and any correlation with blood urea nitrogen (BUN) levels and Kt/V were investigated.
We studied 20 patients on intermittent HD treatment. The first breath samples were taken before the start of dialysis and further breath samples were taken every hour during the treatment and after the end of the session. An evaluation was also made of 20 healthy volunteers, acting as controls [healthy subjects (HS)].
Breath ammonia concentrations were higher in CRDS-HD (914.5±301.4 versus 280±120 parts per billion (p.p.b.), P |
| doi_str_mv | 10.1093/ndt/gfr738 |
| format | Article |
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We studied 20 patients on intermittent HD treatment. The first breath samples were taken before the start of dialysis and further breath samples were taken every hour during the treatment and after the end of the session. An evaluation was also made of 20 healthy volunteers, acting as controls [healthy subjects (HS)].
Breath ammonia concentrations were higher in CRDS-HD (914.5±301.4 versus 280±120 parts per billion (p.p.b.), P<0.0001) and IMS-HD patients (964.4±402.4 versus 280±120 p.p.b., P<0.0001) than in HS. We assessed real-time variations in the levels of NH(3) and showed a continuous decrease in the levels of NH3. Expired NH3 correlated directly with BUN levels, both in the IMS-HD (P=0.002; r=0.84; P=0.009; r=0.76) and in the CRDS-HD group (P=0.005; r=0.80; P=0.008; r=0.77), respectively, both before and at the end of dialysis. A direct correlation with Kt/V was found in both groups studied (IMS-HD: P=0.003; r=0.82; CRDS-HD: P=0.006; r=0.79).
Breath monitoring of NH3 with IMS and CRDS techniques could be useful to assess the real-time clinical status of patients during HD. By using pre-dialysis ammonia values, an approximate calculation of the Kt/Vurea ratio can be established.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfr738</identifier><identifier>PMID: 22492831</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Ammonia - analysis ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Urea Nitrogen ; Blood. Blood coagulation. Reticuloendothelial system ; Breath Tests ; Case-Control Studies ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Glomerular Filtration Rate ; Humans ; Intensive care medicine ; Ions - chemistry ; Male ; Mass Spectrometry ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Prognosis ; Renal Dialysis ; Renal Insufficiency, Chronic - metabolism ; Renal Insufficiency, Chronic - therapy</subject><ispartof>Nephrology, dialysis, transplantation, 2012-07, Vol.27 (7), p.2945-2952</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-5faa6667b5bd54b94e7bb4c4cf3e24bd374295e9a06cd97a75ca2ff9d82214dc3</citedby><cites>FETCH-LOGICAL-c419t-5faa6667b5bd54b94e7bb4c4cf3e24bd374295e9a06cd97a75ca2ff9d82214dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26181033$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22492831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NERI, Giovanni</creatorcontrib><creatorcontrib>LACQUANITI, Antonio</creatorcontrib><creatorcontrib>RIZZO, Giuseppe</creatorcontrib><creatorcontrib>DONATO, Nicola</creatorcontrib><creatorcontrib>LATINO, Mariangela</creatorcontrib><creatorcontrib>BUEMI, Michele</creatorcontrib><title>Real-time monitoring of breath ammonia during haemodialysis: use of ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>The diffusion of high-performance analytical technology has opened prospects for breath diagnosis as a non-invasive diagnostic tool. In this study, ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques were used to analyse ammonia gas (NH3) in real-time in breath from patients undergoing haemodialysis (HD) treatment and any correlation with blood urea nitrogen (BUN) levels and Kt/V were investigated.
We studied 20 patients on intermittent HD treatment. The first breath samples were taken before the start of dialysis and further breath samples were taken every hour during the treatment and after the end of the session. An evaluation was also made of 20 healthy volunteers, acting as controls [healthy subjects (HS)].
Breath ammonia concentrations were higher in CRDS-HD (914.5±301.4 versus 280±120 parts per billion (p.p.b.), P<0.0001) and IMS-HD patients (964.4±402.4 versus 280±120 p.p.b., P<0.0001) than in HS. We assessed real-time variations in the levels of NH(3) and showed a continuous decrease in the levels of NH3. Expired NH3 correlated directly with BUN levels, both in the IMS-HD (P=0.002; r=0.84; P=0.009; r=0.76) and in the CRDS-HD group (P=0.005; r=0.80; P=0.008; r=0.77), respectively, both before and at the end of dialysis. A direct correlation with Kt/V was found in both groups studied (IMS-HD: P=0.003; r=0.82; CRDS-HD: P=0.006; r=0.79).
Breath monitoring of NH3 with IMS and CRDS techniques could be useful to assess the real-time clinical status of patients during HD. By using pre-dialysis ammonia values, an approximate calculation of the Kt/Vurea ratio can be established.</description><subject>Ammonia - analysis</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Urea Nitrogen</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Breath Tests</subject><subject>Case-Control Studies</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Ions - chemistry</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - metabolism</subject><subject>Renal Insufficiency, Chronic - therapy</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0cuKFDEUBuAgitOObnwAyUYYhXJyq0vcSXsbGBFGXRcnt-lIVdImKaWfxNc1ZffoKpD_y0nIj9BTSl5RIvllMOXy1qWeD_fQhoqONIwP7X20qSFtSEvkGXqU83dCiGR9_xCdMSYkGzjdoN83Fqam-NniOQZfYvLhFkeHVbJQdhjmdRuwWf4GO7BzNB6mQ_b5NV6yXa2PoZ5WfvLlgPPe6pLibEs64IurT19eYAgGa_i5puuUxsRf4c5lHffVbW_eVlis3gX_Y7H5MXrgYMr2yWk9R9_ev_u6_dhcf_5wtX1z3WhBZWlaB9B1Xa9aZVqhpLC9UkIL7bhlQhneCyZbK4F02sge-lYDc06agTEqjObn6OI4d5_iem8ZZ5-1nSYINi55pIR1Q8dl21X68kh1fXVO1o375GdIh4rGtYixFjEei6j42WnuomZr_tG7n6_g-QlA1jC5BEH7_N91dKCEc_4HaxqUyA</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>NERI, Giovanni</creator><creator>LACQUANITI, Antonio</creator><creator>RIZZO, Giuseppe</creator><creator>DONATO, Nicola</creator><creator>LATINO, Mariangela</creator><creator>BUEMI, Michele</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Real-time monitoring of breath ammonia during haemodialysis: use of ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques</title><author>NERI, Giovanni ; LACQUANITI, Antonio ; RIZZO, Giuseppe ; DONATO, Nicola ; LATINO, Mariangela ; BUEMI, Michele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-5faa6667b5bd54b94e7bb4c4cf3e24bd374295e9a06cd97a75ca2ff9d82214dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Ammonia - analysis</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Urea Nitrogen</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Breath Tests</topic><topic>Case-Control Studies</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Ions - chemistry</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Renal Dialysis</topic><topic>Renal Insufficiency, Chronic - metabolism</topic><topic>Renal Insufficiency, Chronic - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NERI, Giovanni</creatorcontrib><creatorcontrib>LACQUANITI, Antonio</creatorcontrib><creatorcontrib>RIZZO, Giuseppe</creatorcontrib><creatorcontrib>DONATO, Nicola</creatorcontrib><creatorcontrib>LATINO, Mariangela</creatorcontrib><creatorcontrib>BUEMI, Michele</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NERI, Giovanni</au><au>LACQUANITI, Antonio</au><au>RIZZO, Giuseppe</au><au>DONATO, Nicola</au><au>LATINO, Mariangela</au><au>BUEMI, Michele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-time monitoring of breath ammonia during haemodialysis: use of ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>27</volume><issue>7</issue><spage>2945</spage><epage>2952</epage><pages>2945-2952</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>The diffusion of high-performance analytical technology has opened prospects for breath diagnosis as a non-invasive diagnostic tool. In this study, ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques were used to analyse ammonia gas (NH3) in real-time in breath from patients undergoing haemodialysis (HD) treatment and any correlation with blood urea nitrogen (BUN) levels and Kt/V were investigated.
We studied 20 patients on intermittent HD treatment. The first breath samples were taken before the start of dialysis and further breath samples were taken every hour during the treatment and after the end of the session. An evaluation was also made of 20 healthy volunteers, acting as controls [healthy subjects (HS)].
Breath ammonia concentrations were higher in CRDS-HD (914.5±301.4 versus 280±120 parts per billion (p.p.b.), P<0.0001) and IMS-HD patients (964.4±402.4 versus 280±120 p.p.b., P<0.0001) than in HS. We assessed real-time variations in the levels of NH(3) and showed a continuous decrease in the levels of NH3. Expired NH3 correlated directly with BUN levels, both in the IMS-HD (P=0.002; r=0.84; P=0.009; r=0.76) and in the CRDS-HD group (P=0.005; r=0.80; P=0.008; r=0.77), respectively, both before and at the end of dialysis. A direct correlation with Kt/V was found in both groups studied (IMS-HD: P=0.003; r=0.82; CRDS-HD: P=0.006; r=0.79).
Breath monitoring of NH3 with IMS and CRDS techniques could be useful to assess the real-time clinical status of patients during HD. By using pre-dialysis ammonia values, an approximate calculation of the Kt/Vurea ratio can be established.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22492831</pmid><doi>10.1093/ndt/gfr738</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Ammonia - analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Urea Nitrogen Blood. Blood coagulation. Reticuloendothelial system Breath Tests Case-Control Studies Emergency and intensive care: renal failure. Dialysis management Female Glomerular Filtration Rate Humans Intensive care medicine Ions - chemistry Male Mass Spectrometry Medical sciences Middle Aged Pharmacology. Drug treatments Prognosis Renal Dialysis Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - therapy |
| title | Real-time monitoring of breath ammonia during haemodialysis: use of ion mobility spectrometry (IMS) and cavity ring-down spectroscopy (CRDS) techniques |
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