Effect of epistasis and linkage on fixation probability in three-locus models: An ancestral recombination–selection graph approach

We study the probability of ultimate fixation of a single new mutant arising in an individual chosen at random at a locus linked to two other loci carrying previously arisen mutations. This is done using the Ancestral Recombination–Selection Graph (ARSG) in a finite population in the limit of a larg...

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Veröffentlicht in:	Theoretical population biology 2012-09, Vol.82 (2), p.131-145
Hauptverfasser:	Kermany, Amir R., Lessard, Sabin
Format:	Artikel
Sprache:	eng
Schlagworte:	Ancestral influence graph Ancestral recombination graph Ancestral selection graph Biological Evolution Epistasis, Genetic Evolution of recombination Genetic Loci Genetics, Population Hill–Robertson effect Linkage Disequilibrium Models, Genetic Modifier theory Recombination, Genetic
Online-Zugang:	Volltext
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