Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway

Olprinone, a specific phosphodiesterase III inhibitor, and corforsin daropate, a direct adenylate cyclase activator, are now being used in critical conditions. We investigated whether their therapeutic use provides protection against septic acute lung injury (ALI) and mortality. Polymicrobial sepsis...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2012-07, Vol.303 (2), p.L130-L140
Hauptverfasser:	Oishi, Hirofumi, Takano, Ken-ichi, Tomita, Kengo, Takebe, Mariko, Yokoo, Hiroki, Yamazaki, Mitsuaki, Hattori, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - drug therapy Acute Lung Injury - microbiology Acute Lung Injury - pathology Androstadienes - pharmacology Animals Apoptosis Apoptosis - drug effects Cecum - microbiology Cecum - pathology Colforsin - analogs & derivatives Colforsin - pharmacology Colforsin - therapeutic use Cyclic AMP Response Element-Binding Protein - metabolism Cytokines - blood Cytokines - genetics Cytokines - metabolism Enzyme Activation Enzyme Activators - pharmacology Enzyme Activators - therapeutic use Hypotension - microbiology Imidazoles - pharmacology Imidazoles - therapeutic use Ligation Lung - drug effects Lung - metabolism Lung - pathology Lung diseases Male Mice Mice, Inbred BALB C NF-kappa B - metabolism Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphodiesterase Inhibitors - pharmacology Phosphodiesterase Inhibitors - therapeutic use Phosphorylation Pneumonia - drug therapy Pneumonia - microbiology Pneumonia - pathology Proto-Oncogene Proteins c-akt - metabolism Pyridones - pharmacology Pyridones - therapeutic use Rodents Sepsis Shock, Septic - blood Shock, Septic - drug therapy Shock, Septic - microbiology Signal Transduction
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