27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells

The principal aim of this study was to analyze in estrogen receptor-positive MCF7 cells the response of three estrogen-dependent proteins to 27-hydroxycholesterol (27OHC), a major circulating cholesterol metabolite. Immunofluorescence, immunoblotting and immunogold labelling analyses of MCF7 cells e...

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Veröffentlicht in:	Oncology reports 2012-09, Vol.28 (3), p.992-998
Hauptverfasser:	CRUZ, PAMELA, EPUÑÁN, MARÍA JOSÉ, RAMÍREZ, MARÍA EUGENIA, TORRES, CRISTIAN G, VALLADARES, LUIS E, SIERRALTA, WALTER D
Format:	Artikel
Sprache:	eng
Schlagworte:	27-hydroxycholesterol Biological and medical sciences Breast cancer Cell Line, Tumor EGFR2/neu Epithelial-Mesenchymal Transition ERβ Estradiol - pharmacology Estradiol - physiology Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Estrogens Estrogens - pharmacology Estrogens - physiology Forkhead Box Protein M1 Forkhead Transcription Factors - metabolism FOXM1 Gynecology. Andrology. Obstetrics Humans Hydroxycholesterols - pharmacology Kinases mammary cancer Mammary gland diseases MCF7 cells Medical sciences Mitochondria - enzymology Mitochondria - metabolism Mitochondria - ultrastructure MnSOD Reactive Oxygen Species - metabolism Receptors, Estrogen - metabolism Rodents Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Tumors
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