Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling

Access to the dermis for continuous PK/PD sampling is provided by a new, minimally invasive, membrane-free method: dermal open-flow microperfusion (dOFM). PK profiles and AUC 24h indicate accumulation of BCT194 in the dermis of both psoriatic lesional skin and non-lesional skin. Methodologies for co...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2012-08, Vol.81 (3), p.635-641
Hauptverfasser:	Bodenlenz, Manfred, Höfferer, Christian, Magnes, Christoph, Schaller-Ammann, Roland, Schaupp, Lukas, Feichtner, Franz, Ratzer, Maria, Pickl, Karin, Sinner, Frank, Wutte, Andrea, Korsatko, Stefan, Köhler, Gerd, Legat, Franz J., Benfeldt, Eva M., Wright, Andrew M., Neddermann, Daniel, Jung, Thomas, Pieber, Thomas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Adult Biomarkers - metabolism Chromatography, Liquid - methods Enzyme-Linked Immunosorbent Assay Equipment Design Feasibility Studies Female Humans Male Microdialysis - methods Middle Aged Open-flow microperfusion p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Perfusion - methods Pharmacodynamics Pharmacokinetics Psoriasis Psoriasis - drug therapy Skin penetration Tandem Mass Spectrometry Time Factors Topical drugs Tumor Necrosis Factor-alpha - metabolism Young Adult
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