Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice

Abstract The apolipoprotein ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and is associated with earlier age of onset. The incidence of spontaneous seizures has been reported to be increased in sporadic AD as well as in the early onset autosomal dominant...

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Veröffentlicht in:	Brain research 2012-07, Vol.1467, p.120-132
Hauptverfasser:	Hunter, Jesse M, Cirrito, John R, Restivo, Jessica L, Kinley, Robert D, Sullivan, Patrick M, Holtzman, David M, Koger, Deanna, Delong, Cynthia, Lin, Suizhen, Zhao, Lingzhi, Liu, Feng, Bales, Kelly, Paul, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology alleles Alzheimer Alzheimer disease Amyloid beta Amyloid beta-Peptides - blood Amyloid beta-Peptides - metabolism Animals Apolipoprotein E apolipoprotein E4 Apolipoprotein E4 - blood Apolipoprotein E4 - genetics Behavior, Animal - physiology Biological and medical sciences Biomarkers Body Weight Cerebral Cortex - physiopathology Convulsants death Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electroencephalography Enzyme-Linked Immunosorbent Assay Epilepsy gene overexpression head Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hippocampus Hippocampus - physiopathology Humans Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic neck Nervous system (semeiology, syndromes) neural networks Neurology Neurons - physiology penetrance Pentylenetetrazole Phenotype risk factors Seizure seizures Seizures - chemically induced Seizures - genetics Seizures - physiopathology
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