The expression and role of non-canonical (PKC) signaling in nucleus pulposus cell metabolism

Canonical Wnt/β‐catenin (hereafter Wnt) signaling regulates the proliferation and differentiation of various cell types. However, the role of non‐canonical signaling including protein kinase C (PKC) signaling has not been investigated in intervertebral disc (IVD) cells. The aim of this study was to...

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Veröffentlicht in:	Journal of orthopaedic research 2012-09, Vol.30 (9), p.1478-1485
Hauptverfasser:	Arai, Fumiyuki, Hiyama, Akihiko, Sakai, Daisuke, Yokoyama, Katsuya, Mochida, Joji
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecans - metabolism Animals disc degeneration Glycosaminoglycans - metabolism intervertebral disc (IVD) Intervertebral Disc - enzymology Isoenzymes - metabolism Phorbol Esters PKC signal Protein Kinase C - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Signal Transduction Wnt Proteins - metabolism Wnt signal
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