Effect of Nuclear Receptor Downregulation on Hepatic Expression of Cytochrome P450 and Transporters in Chronic Hepatitis C in Association with Fibrosis Development

Analysis of mRNAs from liver biopsy samples of patients with chronic hepatitis C revealed that the levels of nuclear receptor expression were correlated with those of drug-metabolizing enzymes and transporters in relation to the development of fibrosis. Overall, the median mRNA level was largely dep...

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Veröffentlicht in:	Drug metabolism and pharmacokinetics 2012, Vol.27 (3), p.301-306
Hauptverfasser:	Hanada, Kazuhiko, Nakai, Kenya, Tanaka, Hiromasa, Suzuki, Fumitaka, Kumada, Hiromitsu, Ohno, Yasuo, Ozawa, Shogo, Ogata, Hiroyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult ATP Binding Cassette Transporter, Sub-Family B - genetics ATP Binding Cassette Transporter, Sub-Family B - metabolism Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biopsy Cell Nucleus - metabolism Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochrome P450 and transporters Disease Progression Down-Regulation Female Fibrosis Gene Expression Regulation Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism hepatitis C Hepatitis C, Chronic - enzymology Hepatitis C, Chronic - immunology Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - pathology Humans Liver - immunology Liver - metabolism Liver - pathology liver fibrosis Male Middle Aged mRNA downregulation nuclear receptors Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism Organic Cation Transporter 1 - genetics Organic Cation Transporter 1 - metabolism Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Steroid - genetics Receptors, Steroid - metabolism RNA, Messenger - metabolism Symporters - genetics Symporters - metabolism
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