N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression
Synthetic retinoid N‐(4‐hydroxyphenyl)retinamide (4‐HPR) has been reported to exhibit anti‐invasive and anti‐metastatic activities by suppressing the enzymatic activity of matrix metalloproteinase (MMP)‐9, but the underlying mechanism remains unclear. Here, we show that 4‐HPR blocks the activity of...
Gespeichert in:
| Veröffentlicht in: | Journal of cellular biochemistry 2012-09, Vol.113 (9), p.2845-2855 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2855 |
|---|---|
| container_issue | 9 |
| container_start_page | 2845 |
| container_title | Journal of cellular biochemistry |
| container_volume | 113 |
| creator | Kang, Hyereen Lee, Minjae Choi, Kyung-chul Shin, Dong-Myoung Ko, Jesang Jang, Sung-Wuk |
| description | Synthetic retinoid N‐(4‐hydroxyphenyl)retinamide (4‐HPR) has been reported to exhibit anti‐invasive and anti‐metastatic activities by suppressing the enzymatic activity of matrix metalloproteinase (MMP)‐9, but the underlying mechanism remains unclear. Here, we show that 4‐HPR blocks the activity of MMP‐9 in two ways: by reducing phorbol 12‐myristate 13‐acetate (PMA)‐induced MMP‐9 secretion and by suppressing cell invasion through the downregulation of MMP‐9 gene transcription in MCF‐7 breast cancer cells. 4‐HPR inhibits the transcriptional activity of MMP‐9 by reducing the DNA‐binding activity of NF‐κB on the MMP‐9 promoter as well as by inhibiting the degradation of IκBα, leading to cytoplasmic accumulation of NF‐κB. We also found that 4‐HPR inhibits invasion and MMP‐9 expression in the highly metastatic breast cancer cell line MDA‐MB‐231. Thus, 4‐HPR might be a potent anti‐invasive agent that works by suppressing MMP‐9 expression via the NF‐κB signaling pathway. J. Cell. Biochem. 113: 2845–2855, 2012. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jcb.24159 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1024935345</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1024935345</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4579-68782a717b716caa6ab6c93a5ad4f9b10c135b4bacca5bed75e6e8c4eca5c5473</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhiMEokvhwB9Akbi0h7R2bMfJka5oS6kWofJxtCbObOMlX7WddvNf-LF4SbcHJE6WNc88M6M3it5SckIJSU83ujxJORXFs2hBSSETnnH-PFoQyUiSMpoeRK-c2xBCioKlL6ODNOV5zkmxiH6vkiOe1FNl--001NhNzbFFbzpoTYWx6WpTGu_i0iI4H2voNNpYY9OE2j0403exr20_3taxG4fBonOmu41X58nnsxi0N_fgdxB01d62q7fgrdnGLXpomn6wvccw02FSxLidLX33Onqxhsbhm8f3MPp-_vHb8jK5_nLxafnhOtFcyCLJcpmnIKksJc00QAZlpgsGAiq-LkpKNGWi5CVoDaLESgrMMNccw1cLLtlhdDR7wx53IzqvWuN2N0KH_egUJSkvmGBcBPT9P-imH20XtlOMhjE0pzwN1PFMads7Z3GtBmtasFNQqV1kKkSm_kYW2HePxrFssXoi9xkF4HQGHkyD0_9N6mp5tlcmc4dxHrdPHWB_qUwyKdTP1YW6EtmPr9nNUt2wP1qpsuM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3113518142</pqid></control><display><type>article</type><title>N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kang, Hyereen ; Lee, Minjae ; Choi, Kyung-chul ; Shin, Dong-Myoung ; Ko, Jesang ; Jang, Sung-Wuk</creator><creatorcontrib>Kang, Hyereen ; Lee, Minjae ; Choi, Kyung-chul ; Shin, Dong-Myoung ; Ko, Jesang ; Jang, Sung-Wuk</creatorcontrib><description>Synthetic retinoid N‐(4‐hydroxyphenyl)retinamide (4‐HPR) has been reported to exhibit anti‐invasive and anti‐metastatic activities by suppressing the enzymatic activity of matrix metalloproteinase (MMP)‐9, but the underlying mechanism remains unclear. Here, we show that 4‐HPR blocks the activity of MMP‐9 in two ways: by reducing phorbol 12‐myristate 13‐acetate (PMA)‐induced MMP‐9 secretion and by suppressing cell invasion through the downregulation of MMP‐9 gene transcription in MCF‐7 breast cancer cells. 4‐HPR inhibits the transcriptional activity of MMP‐9 by reducing the DNA‐binding activity of NF‐κB on the MMP‐9 promoter as well as by inhibiting the degradation of IκBα, leading to cytoplasmic accumulation of NF‐κB. We also found that 4‐HPR inhibits invasion and MMP‐9 expression in the highly metastatic breast cancer cell line MDA‐MB‐231. Thus, 4‐HPR might be a potent anti‐invasive agent that works by suppressing MMP‐9 expression via the NF‐κB signaling pathway. J. Cell. Biochem. 113: 2845–2855, 2012. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.24159</identifier><identifier>PMID: 22488409</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>4-HPR ; Acetic acid ; BREAST CANCER ; Breast Neoplasms - metabolism ; Cell activation ; CELL INVASION ; Cell Line ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Electrophoretic Mobility Shift Assay ; Enzymatic activity ; Enzyme-Linked Immunosorbent Assay ; Female ; Fenretinide - pharmacology ; Humans ; Immunoblotting ; Invasiveness ; Matrix metalloproteinase ; Matrix Metalloproteinase 9 - metabolism ; Matrix metalloproteinases ; Metalloproteinase ; Metastases ; MMP-9 ; NF-kappa B - metabolism ; NF-κB ; Reverse Transcriptase Polymerase Chain Reaction ; Signal transduction ; Tetradecanoylphorbol Acetate - pharmacology</subject><ispartof>Journal of cellular biochemistry, 2012-09, Vol.113 (9), p.2845-2855</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><rights>Copyright Wiley Subscription Services, Inc. Sep 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4579-68782a717b716caa6ab6c93a5ad4f9b10c135b4bacca5bed75e6e8c4eca5c5473</citedby><cites>FETCH-LOGICAL-c4579-68782a717b716caa6ab6c93a5ad4f9b10c135b4bacca5bed75e6e8c4eca5c5473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.24159$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.24159$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22488409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Hyereen</creatorcontrib><creatorcontrib>Lee, Minjae</creatorcontrib><creatorcontrib>Choi, Kyung-chul</creatorcontrib><creatorcontrib>Shin, Dong-Myoung</creatorcontrib><creatorcontrib>Ko, Jesang</creatorcontrib><creatorcontrib>Jang, Sung-Wuk</creatorcontrib><title>N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression</title><title>Journal of cellular biochemistry</title><addtitle>J. Cell. Biochem</addtitle><description>Synthetic retinoid N‐(4‐hydroxyphenyl)retinamide (4‐HPR) has been reported to exhibit anti‐invasive and anti‐metastatic activities by suppressing the enzymatic activity of matrix metalloproteinase (MMP)‐9, but the underlying mechanism remains unclear. Here, we show that 4‐HPR blocks the activity of MMP‐9 in two ways: by reducing phorbol 12‐myristate 13‐acetate (PMA)‐induced MMP‐9 secretion and by suppressing cell invasion through the downregulation of MMP‐9 gene transcription in MCF‐7 breast cancer cells. 4‐HPR inhibits the transcriptional activity of MMP‐9 by reducing the DNA‐binding activity of NF‐κB on the MMP‐9 promoter as well as by inhibiting the degradation of IκBα, leading to cytoplasmic accumulation of NF‐κB. We also found that 4‐HPR inhibits invasion and MMP‐9 expression in the highly metastatic breast cancer cell line MDA‐MB‐231. Thus, 4‐HPR might be a potent anti‐invasive agent that works by suppressing MMP‐9 expression via the NF‐κB signaling pathway. J. Cell. Biochem. 113: 2845–2855, 2012. © 2012 Wiley Periodicals, Inc.</description><subject>4-HPR</subject><subject>Acetic acid</subject><subject>BREAST CANCER</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cell activation</subject><subject>CELL INVASION</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Electrophoretic Mobility Shift Assay</subject><subject>Enzymatic activity</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fenretinide - pharmacology</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Invasiveness</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Matrix metalloproteinases</subject><subject>Metalloproteinase</subject><subject>Metastases</subject><subject>MMP-9</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Signal transduction</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhiMEokvhwB9Akbi0h7R2bMfJka5oS6kWofJxtCbObOMlX7WddvNf-LF4SbcHJE6WNc88M6M3it5SckIJSU83ujxJORXFs2hBSSETnnH-PFoQyUiSMpoeRK-c2xBCioKlL6ODNOV5zkmxiH6vkiOe1FNl--001NhNzbFFbzpoTYWx6WpTGu_i0iI4H2voNNpYY9OE2j0403exr20_3taxG4fBonOmu41X58nnsxi0N_fgdxB01d62q7fgrdnGLXpomn6wvccw02FSxLidLX33Onqxhsbhm8f3MPp-_vHb8jK5_nLxafnhOtFcyCLJcpmnIKksJc00QAZlpgsGAiq-LkpKNGWi5CVoDaLESgrMMNccw1cLLtlhdDR7wx53IzqvWuN2N0KH_egUJSkvmGBcBPT9P-imH20XtlOMhjE0pzwN1PFMads7Z3GtBmtasFNQqV1kKkSm_kYW2HePxrFssXoi9xkF4HQGHkyD0_9N6mp5tlcmc4dxHrdPHWB_qUwyKdTP1YW6EtmPr9nNUt2wP1qpsuM</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Kang, Hyereen</creator><creator>Lee, Minjae</creator><creator>Choi, Kyung-chul</creator><creator>Shin, Dong-Myoung</creator><creator>Ko, Jesang</creator><creator>Jang, Sung-Wuk</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression</title><author>Kang, Hyereen ; Lee, Minjae ; Choi, Kyung-chul ; Shin, Dong-Myoung ; Ko, Jesang ; Jang, Sung-Wuk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4579-68782a717b716caa6ab6c93a5ad4f9b10c135b4bacca5bed75e6e8c4eca5c5473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>4-HPR</topic><topic>Acetic acid</topic><topic>BREAST CANCER</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cell activation</topic><topic>CELL INVASION</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Electrophoretic Mobility Shift Assay</topic><topic>Enzymatic activity</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fenretinide - pharmacology</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Invasiveness</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>Matrix metalloproteinases</topic><topic>Metalloproteinase</topic><topic>Metastases</topic><topic>MMP-9</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Signal transduction</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Hyereen</creatorcontrib><creatorcontrib>Lee, Minjae</creatorcontrib><creatorcontrib>Choi, Kyung-chul</creatorcontrib><creatorcontrib>Shin, Dong-Myoung</creatorcontrib><creatorcontrib>Ko, Jesang</creatorcontrib><creatorcontrib>Jang, Sung-Wuk</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Hyereen</au><au>Lee, Minjae</au><au>Choi, Kyung-chul</au><au>Shin, Dong-Myoung</au><au>Ko, Jesang</au><au>Jang, Sung-Wuk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J. Cell. Biochem</addtitle><date>2012-09</date><risdate>2012</risdate><volume>113</volume><issue>9</issue><spage>2845</spage><epage>2855</epage><pages>2845-2855</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>Synthetic retinoid N‐(4‐hydroxyphenyl)retinamide (4‐HPR) has been reported to exhibit anti‐invasive and anti‐metastatic activities by suppressing the enzymatic activity of matrix metalloproteinase (MMP)‐9, but the underlying mechanism remains unclear. Here, we show that 4‐HPR blocks the activity of MMP‐9 in two ways: by reducing phorbol 12‐myristate 13‐acetate (PMA)‐induced MMP‐9 secretion and by suppressing cell invasion through the downregulation of MMP‐9 gene transcription in MCF‐7 breast cancer cells. 4‐HPR inhibits the transcriptional activity of MMP‐9 by reducing the DNA‐binding activity of NF‐κB on the MMP‐9 promoter as well as by inhibiting the degradation of IκBα, leading to cytoplasmic accumulation of NF‐κB. We also found that 4‐HPR inhibits invasion and MMP‐9 expression in the highly metastatic breast cancer cell line MDA‐MB‐231. Thus, 4‐HPR might be a potent anti‐invasive agent that works by suppressing MMP‐9 expression via the NF‐κB signaling pathway. J. Cell. Biochem. 113: 2845–2855, 2012. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22488409</pmid><doi>10.1002/jcb.24159</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0730-2312 |
| ispartof | Journal of cellular biochemistry, 2012-09, Vol.113 (9), p.2845-2855 |
| issn | 0730-2312 1097-4644 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1024935345 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 4-HPR Acetic acid BREAST CANCER Breast Neoplasms - metabolism Cell activation CELL INVASION Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Electrophoretic Mobility Shift Assay Enzymatic activity Enzyme-Linked Immunosorbent Assay Female Fenretinide - pharmacology Humans Immunoblotting Invasiveness Matrix metalloproteinase Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Metalloproteinase Metastases MMP-9 NF-kappa B - metabolism NF-κB Reverse Transcriptase Polymerase Chain Reaction Signal transduction Tetradecanoylphorbol Acetate - pharmacology |
| title | N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T14%3A50%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=N-(4-hydroxyphenyl)retinamide%20inhibits%20breast%20cancer%20cell%20invasion%20through%20suppressing%20NF-KB%20activation%20and%20inhibiting%20matrix%20metalloproteinase-9%20expression&rft.jtitle=Journal%20of%20cellular%20biochemistry&rft.au=Kang,%20Hyereen&rft.date=2012-09&rft.volume=113&rft.issue=9&rft.spage=2845&rft.epage=2855&rft.pages=2845-2855&rft.issn=0730-2312&rft.eissn=1097-4644&rft_id=info:doi/10.1002/jcb.24159&rft_dat=%3Cproquest_cross%3E1024935345%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3113518142&rft_id=info:pmid/22488409&rfr_iscdi=true |