Progressive nonfluent aphasia: A rare clinical subtype of FTLD‐TDP in Japan

Progressive nonfluent aphasia (PNFA) is a clinical subtype of frontotemporal lobar degeneration (FTLD). FTLD with tau accumulation (FTLD‐tau) and FTLD with TDP‐43 accumulation (FTLD‐TDP) both cause PNFA. We reviewed clinical records of 29 FTLD‐TDP cases in the brain archive of our institute and foun...

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Veröffentlicht in:	Neuropathology 2012-06, Vol.32 (3), p.272-279
Hauptverfasser:	Aoki, Naoya, Tsuchiya, Kuniaki, Kobayashi, Zen, Arai, Tetsuaki, Togo, Takashi, Miyazaki, Hiroshi, Kondo, Hiromi, Ishizu, Hideki, Uchikado, Hirotake, Katsuse, Omi, Hirayasu, Yoshio, Akiyama, Haruhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged, 80 and over aphasia apraxia of speech Atrophy Axons Brain Brain - pathology Dementia disorders Disease Progression Fatal Outcome frontal gyrus Frontotemporal dementia Frontotemporal Lobar Degeneration - pathology Frontotemporal Lobar Degeneration - psychology FTLD‐TDP Functional Laterality - physiology Hemispheric laterality Humans Inclusion bodies Inclusion Bodies - pathology Japan Magnetic Resonance Imaging Male Movement disorders MRI Neurites - pathology Neurons - pathology Neuropsychological Tests Primary Progressive Nonfluent Aphasia - pathology Primary Progressive Nonfluent Aphasia - psychology progressive nonfluent aphasia Reviews speech Substantia nigra superior temporal gyrus Tau protein TDP-43 Proteinopathies - pathology TDP‐43 Tissue Fixation Ubiquitin - metabolism
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