Effect of Adenosine-Regulating Agent Acadesine on Morbidity and Mortality Associated With Coronary Artery Bypass Grafting: The RED-CABG Randomized Controlled Trial

CONTEXT Ischemia/reperfusion injury remains an important cause of morbidity and mortality after coronary artery bypass graft (CABG) surgery. In a meta-analysis of randomized controlled trials, perioperative and postoperative infusion of acadesine, a first-in-class adenosine-regulating agent, was ass...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2012-07, Vol.308 (2), p.157-164
Hauptverfasser:	Newman, Mark F, Ferguson, T. Bruce, White, Jennifer A, Ambrosio, Giuseppe, Koglin, Joerg, Nussmeier, Nancy A, Pearl, Ronald G, Pitt, Bertram, Wechsler, Andrew S, Weisel, Richard D, Reece, Tammy L, Lira, Armando, Harrington, Robert A, RED-CABG Steering Committee and Investigators, for the
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - metabolism Aged Aminoimidazole Carboxamide - adverse effects Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - therapeutic use Biological and medical sciences Cardiology. Vascular system Clinical trials Coronary Artery Bypass - adverse effects Coronary Artery Bypass - methods Coronary Artery Bypass - mortality Coronary Artery Disease - surgery Coronary heart disease Double-Blind Method Epidemiology Female General aspects Heart Heart surgery Humans Male Medical sciences Middle Aged Mortality Perioperative Period Public health. Hygiene Public health. Hygiene-occupational medicine Reperfusion Injury - prevention & control Ribonucleosides - adverse effects Ribonucleosides - therapeutic use Stroke Ventricular Dysfunction, Left
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