Organocatalyzed Michael-Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

Organocatalyzed Michael-Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

Asymmetric formal [3+2] cycloadditions of 4-hydroxybut-2-enal, a succinaldehyde surrogate, and nitroalkenes with an organocatalyst provided cyclopentanecarbaldehydes containing four consecutive stereogenic centers with excellent enantioselectivities.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (63), p.7790-7792
Hauptverfasser: Hong, Bor-Cherng, Chen, Po-Yuan, Kotame, Prakash, Lu, Pei-Ying, Lee, Gene-Hsiang, Liao, Ju-Hsiou
Format: Artikel
Sprache:eng
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Zusammenfassung:Asymmetric formal [3+2] cycloadditions of 4-hydroxybut-2-enal, a succinaldehyde surrogate, and nitroalkenes with an organocatalyst provided cyclopentanecarbaldehydes containing four consecutive stereogenic centers with excellent enantioselectivities.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc33309k