Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration
Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal-Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to resi...
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Veröffentlicht in: | Organic & biomolecular chemistry 2012-08, Vol.10 (30), p.5774-5779 |
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container_title | Organic & biomolecular chemistry |
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creator | Cranwell, Philippa B O'Brien, Matthew Browne, Duncan L Koos, Peter Polyzos, Anastasios Peña-López, Miguel Ley, Steven V |
description | Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal-Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature. |
doi_str_mv | 10.1039/c2ob25407g |
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source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
subjects | Ammonia - chemistry Chemistry Techniques, Synthetic - instrumentation Polytetrafluoroethylene - chemistry Pyrroles - chemical synthesis Pyrroles - chemistry |
title | Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration |
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