Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration

Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal-Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to resi...

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Veröffentlicht in:Organic & biomolecular chemistry 2012-08, Vol.10 (30), p.5774-5779
Hauptverfasser: Cranwell, Philippa B, O'Brien, Matthew, Browne, Duncan L, Koos, Peter, Polyzos, Anastasios, Peña-López, Miguel, Ley, Steven V
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container_issue 30
container_start_page 5774
container_title Organic & biomolecular chemistry
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creator Cranwell, Philippa B
O'Brien, Matthew
Browne, Duncan L
Koos, Peter
Polyzos, Anastasios
Peña-López, Miguel
Ley, Steven V
description Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal-Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature.
doi_str_mv 10.1039/c2ob25407g
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source MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Ammonia - chemistry
Chemistry Techniques, Synthetic - instrumentation
Polytetrafluoroethylene - chemistry
Pyrroles - chemical synthesis
Pyrroles - chemistry
title Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration
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