Mutations in Streptococcus pneumoniae Penicillin-Binding Protein 2x: Importance of the C-Terminal Penicillin-Binding Protein and Serine/Threonine Kinase-Associated Domains for Beta-Lactam Binding

Penicillin-binding protein 2x (PBP2x) mutations that occur during the selection with beta-lactams are located within the central penicillin-binding/transpeptidase (TP) domain, and are believed to mediate resistance by interfering with the formation of a covalent complex of the active site serine wit...

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Veröffentlicht in:	Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2012-06, Vol.18 (3), p.314-321
Hauptverfasser:	Maurer, Patrick, Todorova, Katya, Sauerbier, Julia, Hakenbeck, Regine
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Antibiotics Binding Sites Boron Compounds - chemistry Boron Compounds - metabolism Cefotaxime Cefotaxime - chemistry Cefotaxime - metabolism Cefuroxime Cefuroxime - chemistry Cefuroxime - metabolism Computer Simulation Crystallography, X-Ray Drug resistance Drug Resistance, Microbial - genetics Great Wall Symposium Ionizing radiation Models, Molecular Mutation Pasta Penicillin penicillin-binding protein penicillin-binding protein 2x Penicillin-Binding Proteins - chemistry Penicillin-Binding Proteins - genetics Penicillin-Binding Proteins - metabolism Penicillins - chemistry Penicillins - metabolism Point Mutation Protein Binding Protein Structure, Tertiary Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-serine/threonine kinase Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Serine Serine - chemistry Serine - metabolism Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - genetics Streptococcus pneumoniae - metabolism Structure-Activity Relationship Threonine
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