Possible therapeutic effects of myxobacterial metabolites on type I Gaucher disease

Gaucher disease (GD) is the most prevalent lysosomal storage disorder caused by an inherited deficiency of glucocerebrosidase. In the present study, we aimed to determine whether myxobacterial metabolites exhibit a potential therapeutic effect in the cells from a patient with type I GD. We screened...

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Veröffentlicht in:	Gene 2012-08, Vol.504 (2), p.156-159
Hauptverfasser:	Kim, Sung-Jo, Kang, Sunyang, Kim, June-Bum
Format:	Artikel
Sprache:	eng
Schlagworte:	acetyl-CoA acetyltransferase Acetyl-CoA C-Acetyltransferase - metabolism Acetyltransferase ATP Citrate (pro-S)-Lyase - metabolism Bacterial Proteins - therapeutic use Bax protein bcl-2-Associated X Protein - metabolism bioactive properties Blotting, Western Cell Division cell viability Cells, Cultured Chromatography, Thin Layer E3-binding protein Fibroblasts Gaucher disease Gaucher Disease - metabolism Gaucher Disease - pathology Gaucher Disease - therapy Gaucher's disease Glucosylceramidase Humans Lysosomal storage disease lysosomal storage diseases Metabolites Molecular modelling Myxobacteria Myxococcales - metabolism patients Pyruvate Dehydrogenase Complex - metabolism screening Skin therapeutics Therapy Thin-layer chromatography Western blotting X protein
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