Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and alpha-internexin immunoreactivity

Abstract Axonal degeneration is a prominent feature of amyotrophic lateral sclerosis (ALS) both in lower motor nerves as well as descending white matter axons in the spinal cord of human patients. Although the pathology of lower motor axonal degeneration has been described in both human ALS and rela...

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Veröffentlicht in:	Brain research 2012-07, Vol.1465, p.90-100
Hauptverfasser:	King, Anna E, Blizzard, Catherine A, Southam, Katherine A, Vickers, James C, Dickson, Tracey C
Format:	Artikel
Sprache:	eng
Schlagworte:	Age ALS Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animal models Animals Axon degeneration Axons Axons - metabolism Axons - pathology Biological and medical sciences brain Data processing Development. Senescence. Regeneration. Transplantation Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Green fluorescent protein Green Fluorescent Proteins - genetics Humans immunohistochemistry Immunoreactivity Intermediate Filament Proteins - metabolism Intermediate filaments Light chains Male Mice Mice, Inbred C57BL Mice, Transgenic Molecular modelling motor neurons Motor Neurons - metabolism Motor Neurons - pathology mutants Nerve Degeneration - genetics Nerve Degeneration - metabolism Nerve Degeneration - pathology Nerves Neurodegeneration Neurofilament Proteins - metabolism Neurofilaments Neurology Neuronal intermediate filament Neurons patients sclerosis Spinal cord Spinal Cord - pathology Spinal Cord - physiopathology Spinal Cord Diseases - genetics Spinal Cord Diseases - metabolism Spinal Cord Diseases - pathology Substantia alba Superoxide superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Transgenic animals Vertebrates: nervous system and sense organs Western blotting
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