Characteristics of Klebsiella pneumoniae harboring QnrB32, Aac(6’)-Ib-cr, GyrA and CTX-M-22 genes
Quinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of topoisomerase genes. CTX-M-22 is a member of the CTX-M family which can reduce extended-spectrum [beta]-lactamase (ESBL) production and modulate antibiotic r...
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| Veröffentlicht in: | Folia histochemica et cytobiologica 2012-01, Vol.50 (1), p.68-74 |
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| description | Quinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of topoisomerase genes. CTX-M-22 is a member of the CTX-M family which can reduce extended-spectrum [beta]-lactamase (ESBL) production and modulate antibiotic resistance, resulting in low ceftazidime minimum inhibitory concentrations (MICs). There are four different genes in Klebsiella pneumoniae (KP4707) including qnrB32 (novel qnr allele gene, HQ704413), aac(6')-Ib-cr (novel aac(6')-Ib allele gene, HQ680690), gyrA (novel gyrA allele gene, HQ680691) and CTX-M-22 gene. Five point amino acid mutations Arn(N)27 [arrow right] Leu(L), Val(V)129 [arrow right] Ala(A), Iie(I)142 [arrow right] Met(M), Gly(G)188 [arrow right] Arg(R), Val(V)212 [arrow right] Iie(I) were observed in the qnr32 gene when compared to qnrB1. Of all qnrB alleles, a novel variant of the qnrB32 gene, with qnrB31, had the highest amino acid homology. Three point amino acid mutations including Trp(W)105 [arrow right] Arg(R), Asp(D)182 [arrow right] Tyr(Y) and Val(V)201 [arrow right] Asp(D) were observed in aac(6')-Ib-cr gene, when compared to GenBank number AF479774. New variants of qnr32, aac(6')-Ib-cr, gyrA and CTX-M-22 or other genotype determinants continuously appear in different genomic sites and also outside the Enterobacteriaceae family. |
| doi_str_mv | 10.5603/FHC.2012.0009 |
| format | Article |
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CTX-M-22 is a member of the CTX-M family which can reduce extended-spectrum [beta]-lactamase (ESBL) production and modulate antibiotic resistance, resulting in low ceftazidime minimum inhibitory concentrations (MICs). There are four different genes in Klebsiella pneumoniae (KP4707) including qnrB32 (novel qnr allele gene, HQ704413), aac(6')-Ib-cr (novel aac(6')-Ib allele gene, HQ680690), gyrA (novel gyrA allele gene, HQ680691) and CTX-M-22 gene. Five point amino acid mutations Arn(N)27 [arrow right] Leu(L), Val(V)129 [arrow right] Ala(A), Iie(I)142 [arrow right] Met(M), Gly(G)188 [arrow right] Arg(R), Val(V)212 [arrow right] Iie(I) were observed in the qnr32 gene when compared to qnrB1. Of all qnrB alleles, a novel variant of the qnrB32 gene, with qnrB31, had the highest amino acid homology. Three point amino acid mutations including Trp(W)105 [arrow right] Arg(R), Asp(D)182 [arrow right] Tyr(Y) and Val(V)201 [arrow right] Asp(D) were observed in aac(6')-Ib-cr gene, when compared to GenBank number AF479774. New variants of qnr32, aac(6')-Ib-cr, gyrA and CTX-M-22 or other genotype determinants continuously appear in different genomic sites and also outside the Enterobacteriaceae family.</description><identifier>ISSN: 0239-8508</identifier><identifier>EISSN: 1897-5631</identifier><identifier>DOI: 10.5603/FHC.2012.0009</identifier><language>eng</language><publisher>Bialystok: Wydawnictwo Via Medica</publisher><subject>Alleles ; Amino acids ; Antibiotic resistance ; Antibiotics ; beta -Lactamase ; Ceftazidime ; Enterobacteriaceae ; Genes ; genomics ; Genotypes ; Homology ; Klebsiella ; Klebsiella pneumoniae ; Minimum inhibitory concentration ; Mutation ; Quinolones ; β Lactamase</subject><ispartof>Folia histochemica et cytobiologica, 2012-01, Vol.50 (1), p.68-74</ispartof><rights>Copyright Folia Histochemica et Cytobiologica 2012</rights><rights>2012. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-57da1704f0c2aeeceaf86618666d09c1b2365a1904d0ea52d8c5b13a9136c5a73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids></links><search><creatorcontrib>Wang, Dongguo</creatorcontrib><creatorcontrib>Wang, Haibao</creatorcontrib><creatorcontrib>Qi, Yongxiao</creatorcontrib><creatorcontrib>Liang, Yong</creatorcontrib><creatorcontrib>Zhang, Jin</creatorcontrib><creatorcontrib>Yu, Lianhua</creatorcontrib><title>Characteristics of Klebsiella pneumoniae harboring QnrB32, Aac(6’)-Ib-cr, GyrA and CTX-M-22 genes</title><title>Folia histochemica et cytobiologica</title><description>Quinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of topoisomerase genes. CTX-M-22 is a member of the CTX-M family which can reduce extended-spectrum [beta]-lactamase (ESBL) production and modulate antibiotic resistance, resulting in low ceftazidime minimum inhibitory concentrations (MICs). There are four different genes in Klebsiella pneumoniae (KP4707) including qnrB32 (novel qnr allele gene, HQ704413), aac(6')-Ib-cr (novel aac(6')-Ib allele gene, HQ680690), gyrA (novel gyrA allele gene, HQ680691) and CTX-M-22 gene. Five point amino acid mutations Arn(N)27 [arrow right] Leu(L), Val(V)129 [arrow right] Ala(A), Iie(I)142 [arrow right] Met(M), Gly(G)188 [arrow right] Arg(R), Val(V)212 [arrow right] Iie(I) were observed in the qnr32 gene when compared to qnrB1. Of all qnrB alleles, a novel variant of the qnrB32 gene, with qnrB31, had the highest amino acid homology. Three point amino acid mutations including Trp(W)105 [arrow right] Arg(R), Asp(D)182 [arrow right] Tyr(Y) and Val(V)201 [arrow right] Asp(D) were observed in aac(6')-Ib-cr gene, when compared to GenBank number AF479774. New variants of qnr32, aac(6')-Ib-cr, gyrA and CTX-M-22 or other genotype determinants continuously appear in different genomic sites and also outside the Enterobacteriaceae family.</description><subject>Alleles</subject><subject>Amino acids</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>beta -Lactamase</subject><subject>Ceftazidime</subject><subject>Enterobacteriaceae</subject><subject>Genes</subject><subject>genomics</subject><subject>Genotypes</subject><subject>Homology</subject><subject>Klebsiella</subject><subject>Klebsiella pneumoniae</subject><subject>Minimum inhibitory concentration</subject><subject>Mutation</subject><subject>Quinolones</subject><subject>β Lactamase</subject><issn>0239-8508</issn><issn>1897-5631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kb1OwzAURi0EEqUwsltiKVJdru3YScYS0R9RhJCKxBY5jlNSpUmxk6Ebr8Hr8SQ4KhMDw9VdzvfpXh2ErilMhAR-N1skEwaUTQAgPkEDGsUhEZLTUzQAxmMSCYjO0YVzWwCfCOgA6eRdWaVbY0vXltrhpsCPlclcaapK4X1tul1Tl8pgz2WNLesNfqntPWdjPFV6JL8_v27JMiPajvH8YKdY1TlO1m_kiTCGN6Y27hKdFapy5up3D9Hr7GGdLMjqeb5MpiuiOZMtEWGuaAhBAZopY7RRRSQl9SNziDXNGJdC0RiCHIwSLI-0yChXMeVSCxXyIRode_e2-eiMa9Nd6XT_R22azqUUWCClEBF49OYPum06W_vrUiZjFoHkQfgf5buASiFD6SlypLRtnLOmSPe23Cl78FDai0m9mLQXk_Zi-A_pMHyI</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Wang, Dongguo</creator><creator>Wang, Haibao</creator><creator>Qi, Yongxiao</creator><creator>Liang, Yong</creator><creator>Zhang, Jin</creator><creator>Yu, Lianhua</creator><general>Wydawnictwo Via Medica</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20120101</creationdate><title>Characteristics of Klebsiella pneumoniae harboring QnrB32, Aac(6’)-Ib-cr, GyrA and CTX-M-22 genes</title><author>Wang, Dongguo ; 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CTX-M-22 is a member of the CTX-M family which can reduce extended-spectrum [beta]-lactamase (ESBL) production and modulate antibiotic resistance, resulting in low ceftazidime minimum inhibitory concentrations (MICs). There are four different genes in Klebsiella pneumoniae (KP4707) including qnrB32 (novel qnr allele gene, HQ704413), aac(6')-Ib-cr (novel aac(6')-Ib allele gene, HQ680690), gyrA (novel gyrA allele gene, HQ680691) and CTX-M-22 gene. Five point amino acid mutations Arn(N)27 [arrow right] Leu(L), Val(V)129 [arrow right] Ala(A), Iie(I)142 [arrow right] Met(M), Gly(G)188 [arrow right] Arg(R), Val(V)212 [arrow right] Iie(I) were observed in the qnr32 gene when compared to qnrB1. Of all qnrB alleles, a novel variant of the qnrB32 gene, with qnrB31, had the highest amino acid homology. Three point amino acid mutations including Trp(W)105 [arrow right] Arg(R), Asp(D)182 [arrow right] Tyr(Y) and Val(V)201 [arrow right] Asp(D) were observed in aac(6')-Ib-cr gene, when compared to GenBank number AF479774. New variants of qnr32, aac(6')-Ib-cr, gyrA and CTX-M-22 or other genotype determinants continuously appear in different genomic sites and also outside the Enterobacteriaceae family.</abstract><cop>Bialystok</cop><pub>Wydawnictwo Via Medica</pub><doi>10.5603/FHC.2012.0009</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Amino acids Antibiotic resistance Antibiotics beta -Lactamase Ceftazidime Enterobacteriaceae Genes genomics Genotypes Homology Klebsiella Klebsiella pneumoniae Minimum inhibitory concentration Mutation Quinolones β Lactamase |
| title | Characteristics of Klebsiella pneumoniae harboring QnrB32, Aac(6’)-Ib-cr, GyrA and CTX-M-22 genes |
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