Eosinophil peroxidase induces the expression and function of acid-sensing ion channel-3 in allergic rhinitis: in vitro evidence in cultured epithelial cells

Summary Background Acid‐sensing ion channels (ASIC) are a family of acid‐activated ligand‐gated cation channels. As tissue acidosis is a feature of inflammatory conditions, such as allergic rhinitis (AR), we investigated the expression and function of these channels in AR. Objectives The aim of the...

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Veröffentlicht in:	Clinical and experimental allergy 2012-07, Vol.42 (7), p.1028-1039
Hauptverfasser:	G. Khoo, S., Al-Alawi, M., Walsh, M. T., Hennigan, K., Glynn, S., Thornton, M., McQuaid, S., Wang, Y., Hamilton, P. W., Verriere, V., Gleich, G. J., Harvey, B. J., Costello, R. W., McGarvey, L. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels acid-activated ligand-gated cation channels Acidity Acidosis Adolescent Adult Allergic rhinitis Amiloride Biological and medical sciences Biopsy cation channels Cells, Cultured Chloride Data processing eosinophil Eosinophil Peroxidase - metabolism Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium Extracellular signal-regulated kinase Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Humans Immunohistochemistry Inflammation Lactic acid Lactic Acid - pharmacology Leukocytes (eosinophilic) Male MAP Kinase Signaling System Medical sciences Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mucosa Nasal Mucosa - metabolism Nasal Mucosa - pathology Non tumoral diseases Nose Otorhinolaryngology. Stomatology Peroxidase pH effects Polymerase Chain Reaction Rhinitis, Allergic, Seasonal - metabolism Rhinitis, Allergic, Seasonal - pathology Sodium channels Sodium Channels - biosynthesis Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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