Silencing of miR20a Is Crucial for Ngn1-Mediated Neuroprotection in Injured Spinal Cord

MicroRNAs (miRNAs) compose a relatively new discipline in biomedical research, and many physiological processes in disease have been associated with changes in miRNA expression. Several studies report that miRNAs participate in biological processes such as the control of secondary injury in several...

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Veröffentlicht in:	Human gene therapy 2012-05, Vol.23 (5), p.508-520
Hauptverfasser:	Jee, Min Ki, Jung, Jin Sun, Im, Young Bin, Jung, Sung Jun, Kang, Soo Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Basic Helix-Loop-Helix Transcription Factors - administration & dosage Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors Basic Helix-Loop-Helix Transcription Factors - metabolism Biological and medical sciences Biotechnology Cell survival Cell Survival - genetics Degeneration Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics Gene therapy Health. Pharmaceutical industry Hindlimb - pathology Humans Industrial applications and implications. Economical aspects Inflammation Medical sciences Mice MicroRNAs - antagonists & inhibitors MicroRNAs - genetics miRNA Motor neurons Motor Neurons - metabolism Motor Neurons - pathology Myelin Myelin Sheath - pathology Nerve Tissue Proteins - administration & dosage Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - metabolism Neurogenesis neurogenin 1 Neuroprotection Regeneration RNA Interference Spinal Cord - metabolism Spinal Cord - pathology Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal Cord Injuries - therapy Spinal cord injury Therapeutic applications Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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