Magnetic Resonance Imaging Targeted Biopsy in Men with Previously Negative Prostate Biopsy Results
To evaluate the efficacy of targeted prostate biopsy using magnetic resonance imaging (MRI) and to characterize clinicopathologic features of tumors detected with targeted prostate biopsy in men with previous negative prostate biopsy results. We prospectively studied 87 patients with a persistently...
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| Veröffentlicht in: | Journal of endourology 2012-07, Vol.26 (7), p.787-791 |
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| creator | Lee, Seung Hwan Chung, Mun Su Kim, Joo Hee Oh, Young Taik Rha, Koon Ho Chung, Byung Ha |
| description | To evaluate the efficacy of targeted prostate biopsy using magnetic resonance imaging (MRI) and to characterize clinicopathologic features of tumors detected with targeted prostate biopsy in men with previous negative prostate biopsy results.
We prospectively studied 87 patients with a persistently increasing level of serum prostate-specific antigen (PSA), at least one previous set of negative 12-core prostate biopsies, and normal digital rectal examination. All patients were examined with combined T2-weighted and diffusion-weighted MRI before undergoing the prostate biopsy. Prostate biopsy was performed using transrectal ultrasonography-guided standard 12 cores plus targeted biopsy to suspicious region(s) as identified on T2 images on their MRI.
Of a total of 87 cases, 82 (94.2%) patients had suspicious lesion(s) on their MRI. Of these 82 patients, 46 (56.0%) patients had prostate cancer (PCA) as determined by the biopsy. The patients with PCA showed a significantly higher incidence of having suspicious lesion(s) (the anterior or apex) on MRI than the patients without PCA (P |
| doi_str_mv | 10.1089/end.2011.0393 |
| format | Article |
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We prospectively studied 87 patients with a persistently increasing level of serum prostate-specific antigen (PSA), at least one previous set of negative 12-core prostate biopsies, and normal digital rectal examination. All patients were examined with combined T2-weighted and diffusion-weighted MRI before undergoing the prostate biopsy. Prostate biopsy was performed using transrectal ultrasonography-guided standard 12 cores plus targeted biopsy to suspicious region(s) as identified on T2 images on their MRI.
Of a total of 87 cases, 82 (94.2%) patients had suspicious lesion(s) on their MRI. Of these 82 patients, 46 (56.0%) patients had prostate cancer (PCA) as determined by the biopsy. The patients with PCA showed a significantly higher incidence of having suspicious lesion(s) (the anterior or apex) on MRI than the patients without PCA (P<0.05). On analysis by dividing all biopsy cores into the targeted cores and standard cores, PCA was found in 149/518 (28.8%) MRI-targeted cores and in 32/903 (3.6%) standard cores (P=0.012) Of 43 patients who underwent radical prostatectomy, 37 (86.0%) patients were detected with PCA located at the anterior or apex portion of the prostate. For tumor characteristics according to tumor locations, there was no significant correlation between tumor location and Gleason scores or pathologic stage.
Our data suggest that a MRI-targeted prostate biopsy after prostate MRI might be considered for the identification of cancer foci and the detection of PCA, for patients with a previous negative standard prostate biopsy result despite a persistently elevated PSA value.</description><identifier>ISSN: 0892-7790</identifier><identifier>EISSN: 1557-900X</identifier><identifier>DOI: 10.1089/end.2011.0393</identifier><identifier>PMID: 22122555</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Biopsy ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Prostate - pathology ; Prostate-Specific Antigen - blood ; Prostatectomy ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Reproducibility of Results</subject><ispartof>Journal of endourology, 2012-07, Vol.26 (7), p.787-791</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-954a1e3f80fe294175357e437efa7ab6b747e7212ade0af01b478d567e0f44db3</citedby><cites>FETCH-LOGICAL-c323t-954a1e3f80fe294175357e437efa7ab6b747e7212ade0af01b478d567e0f44db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26380447$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22122555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Seung Hwan</creatorcontrib><creatorcontrib>Chung, Mun Su</creatorcontrib><creatorcontrib>Kim, Joo Hee</creatorcontrib><creatorcontrib>Oh, Young Taik</creatorcontrib><creatorcontrib>Rha, Koon Ho</creatorcontrib><creatorcontrib>Chung, Byung Ha</creatorcontrib><title>Magnetic Resonance Imaging Targeted Biopsy in Men with Previously Negative Prostate Biopsy Results</title><title>Journal of endourology</title><addtitle>J Endourol</addtitle><description>To evaluate the efficacy of targeted prostate biopsy using magnetic resonance imaging (MRI) and to characterize clinicopathologic features of tumors detected with targeted prostate biopsy in men with previous negative prostate biopsy results.
We prospectively studied 87 patients with a persistently increasing level of serum prostate-specific antigen (PSA), at least one previous set of negative 12-core prostate biopsies, and normal digital rectal examination. All patients were examined with combined T2-weighted and diffusion-weighted MRI before undergoing the prostate biopsy. Prostate biopsy was performed using transrectal ultrasonography-guided standard 12 cores plus targeted biopsy to suspicious region(s) as identified on T2 images on their MRI.
Of a total of 87 cases, 82 (94.2%) patients had suspicious lesion(s) on their MRI. Of these 82 patients, 46 (56.0%) patients had prostate cancer (PCA) as determined by the biopsy. The patients with PCA showed a significantly higher incidence of having suspicious lesion(s) (the anterior or apex) on MRI than the patients without PCA (P<0.05). On analysis by dividing all biopsy cores into the targeted cores and standard cores, PCA was found in 149/518 (28.8%) MRI-targeted cores and in 32/903 (3.6%) standard cores (P=0.012) Of 43 patients who underwent radical prostatectomy, 37 (86.0%) patients were detected with PCA located at the anterior or apex portion of the prostate. For tumor characteristics according to tumor locations, there was no significant correlation between tumor location and Gleason scores or pathologic stage.
Our data suggest that a MRI-targeted prostate biopsy after prostate MRI might be considered for the identification of cancer foci and the detection of PCA, for patients with a previous negative standard prostate biopsy result despite a persistently elevated PSA value.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostate - pathology</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Reproducibility of Results</subject><issn>0892-7790</issn><issn>1557-900X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AUhQdRbK0u3cpsBDep88wkSy0-CvWBVHAXJsmdOJImNTOp9N87pa2uLpz7cTh8CJ1TMqYkSa-hKceMUDomPOUHaEilVFFKyMchGoY_i5RKyQCdOPdFCOUx5cdowBhlTEo5RPmTrhrwtsBv4NpGNwXg6UJXtqnwXHcVeCjxrW2Xbo1tg5-gwT_Wf-LXDla27V29xs9QaW9XELLWee1hz4fGvvbuFB0ZXTs4290Rer-_m08eo9nLw3RyM4sKzriPUik0BW4SYoClgirJpQLBFRitdB7nSihQYbgugWhDaC5UUspYATFClDkfoatt77Jrv3twPltYV0Bd6wbC0owSJmIh4lQENNqiRZjsOjDZsrML3a0DlG20ZkFrttGabbQG_mJX3ecLKP_ovccAXO4A7Qpdmy6ItO6fi3lChFD8F0xDgJg</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Lee, Seung Hwan</creator><creator>Chung, Mun Su</creator><creator>Kim, Joo Hee</creator><creator>Oh, Young Taik</creator><creator>Rha, Koon Ho</creator><creator>Chung, Byung Ha</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Magnetic Resonance Imaging Targeted Biopsy in Men with Previously Negative Prostate Biopsy Results</title><author>Lee, Seung Hwan ; Chung, Mun Su ; Kim, Joo Hee ; Oh, Young Taik ; Rha, Koon Ho ; Chung, Byung Ha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-954a1e3f80fe294175357e437efa7ab6b747e7212ade0af01b478d567e0f44db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prostate - pathology</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Seung Hwan</creatorcontrib><creatorcontrib>Chung, Mun Su</creatorcontrib><creatorcontrib>Kim, Joo Hee</creatorcontrib><creatorcontrib>Oh, Young Taik</creatorcontrib><creatorcontrib>Rha, Koon Ho</creatorcontrib><creatorcontrib>Chung, Byung Ha</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endourology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seung Hwan</au><au>Chung, Mun Su</au><au>Kim, Joo Hee</au><au>Oh, Young Taik</au><au>Rha, Koon Ho</au><au>Chung, Byung Ha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic Resonance Imaging Targeted Biopsy in Men with Previously Negative Prostate Biopsy Results</atitle><jtitle>Journal of endourology</jtitle><addtitle>J Endourol</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>26</volume><issue>7</issue><spage>787</spage><epage>791</epage><pages>787-791</pages><issn>0892-7790</issn><eissn>1557-900X</eissn><abstract>To evaluate the efficacy of targeted prostate biopsy using magnetic resonance imaging (MRI) and to characterize clinicopathologic features of tumors detected with targeted prostate biopsy in men with previous negative prostate biopsy results.
We prospectively studied 87 patients with a persistently increasing level of serum prostate-specific antigen (PSA), at least one previous set of negative 12-core prostate biopsies, and normal digital rectal examination. All patients were examined with combined T2-weighted and diffusion-weighted MRI before undergoing the prostate biopsy. Prostate biopsy was performed using transrectal ultrasonography-guided standard 12 cores plus targeted biopsy to suspicious region(s) as identified on T2 images on their MRI.
Of a total of 87 cases, 82 (94.2%) patients had suspicious lesion(s) on their MRI. Of these 82 patients, 46 (56.0%) patients had prostate cancer (PCA) as determined by the biopsy. The patients with PCA showed a significantly higher incidence of having suspicious lesion(s) (the anterior or apex) on MRI than the patients without PCA (P<0.05). On analysis by dividing all biopsy cores into the targeted cores and standard cores, PCA was found in 149/518 (28.8%) MRI-targeted cores and in 32/903 (3.6%) standard cores (P=0.012) Of 43 patients who underwent radical prostatectomy, 37 (86.0%) patients were detected with PCA located at the anterior or apex portion of the prostate. For tumor characteristics according to tumor locations, there was no significant correlation between tumor location and Gleason scores or pathologic stage.
Our data suggest that a MRI-targeted prostate biopsy after prostate MRI might be considered for the identification of cancer foci and the detection of PCA, for patients with a previous negative standard prostate biopsy result despite a persistently elevated PSA value.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>22122555</pmid><doi>10.1089/end.2011.0393</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Biopsy Humans Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Prostate - pathology Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - blood Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Reproducibility of Results |
| title | Magnetic Resonance Imaging Targeted Biopsy in Men with Previously Negative Prostate Biopsy Results |
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