Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis of cardiac involvement and risk stratification in primary systematic (AL) amyloidosis: a 5-year cohort study
To determine the role of assessing right ventricular (RV) function, using standard echocardiography and Doppler myocardial imaging (DMI), in the early diagnosis of cardiac amyloidosis and in the prediction of mortality. Patients with primary systemic (AL) amyloidosis seen at our institution from 1 F...
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| Veröffentlicht in: | European heart journal cardiovascular imaging 2012-08, Vol.13 (8), p.680-689 |
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| creator | Bellavia, Diego Pellikka, Patricia A Dispenzieri, Angela Scott, Christopher G Al-Zahrani, Ghormallah B Grogan, Martha Pitrolo, Francesco Oh, Jae K Miller, Jr, Fletcher A |
| description | To determine the role of assessing right ventricular (RV) function, using standard echocardiography and Doppler myocardial imaging (DMI), in the early diagnosis of cardiac amyloidosis and in the prediction of mortality.
Patients with primary systemic (AL) amyloidosis seen at our institution from 1 February 2004 through 31 October 2005 (N=249) were categorized by left ventricular thickness and E' velocity and compared with 38 age- and sex-matched controls. Standard echocardiographic and DMI examination were used to measure echocardiographic parameters of RV function: systolic tissue velocity, strain rate, and strain were determined for basal and middle RV free wall segments. Patients were followed up for the endpoint of mortality. RV tricuspid annular plane systolic excursion (TAPSE) and all DMI measurements were lower in patients with AL amyloidosis and normal echocardiography results (AL-normal-echo group) than controls. A bivariate model including strain of the basal segment of the RV free wall and TAPSE was the best for distinguishing AL-normal-echo patients from controls. Male sex [hazard ratio (HR), 2.2; P=0.005], brain natriuretic peptide levels (HR 1.4; P=0.003), troponin T levels (HR 1.6; P=0.01), pleural effusion (HR 3.6; P |
| doi_str_mv | 10.1093/ehjci/jes009 |
| format | Article |
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Patients with primary systemic (AL) amyloidosis seen at our institution from 1 February 2004 through 31 October 2005 (N=249) were categorized by left ventricular thickness and E' velocity and compared with 38 age- and sex-matched controls. Standard echocardiographic and DMI examination were used to measure echocardiographic parameters of RV function: systolic tissue velocity, strain rate, and strain were determined for basal and middle RV free wall segments. Patients were followed up for the endpoint of mortality. RV tricuspid annular plane systolic excursion (TAPSE) and all DMI measurements were lower in patients with AL amyloidosis and normal echocardiography results (AL-normal-echo group) than controls. A bivariate model including strain of the basal segment of the RV free wall and TAPSE was the best for distinguishing AL-normal-echo patients from controls. Male sex [hazard ratio (HR), 2.2; P=0.005], brain natriuretic peptide levels (HR 1.4; P=0.003), troponin T levels (HR 1.6; P=0.01), pleural effusion (HR 3.6; P<0.001), E/A ratio (HR 1.3; P=0.006), RV systolic pressure (HR 1.02; P=0.01), and RV strain rate of the middle segment (HR 1.3; P=0.02) were independent predictors of death.
DMI measures of the RV can identify early impairment of cardiac function or stratify risk of death in patients with AL amyloidosis. Further studies with longer follow-up are warranted to confirm these results.</description><identifier>ISSN: 2047-2404</identifier><identifier>EISSN: 2047-2412</identifier><identifier>DOI: 10.1093/ehjci/jes009</identifier><identifier>PMID: 22307866</identifier><language>eng</language><publisher>England</publisher><subject>Amyloidosis - diagnostic imaging ; Amyloidosis - physiopathology ; Biomarkers - analysis ; Case-Control Studies ; Echocardiography, Doppler ; Electrocardiography ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Immunoglobulin Light-chain Amyloidosis ; Male ; Middle Aged ; Prospective Studies ; Reproducibility of Results ; Risk Assessment ; ROC Curve ; Statistics, Nonparametric ; Survival Analysis ; Tricuspid Valve - diagnostic imaging ; Tricuspid Valve - physiopathology ; Ventricular Dysfunction, Right - diagnostic imaging ; Ventricular Dysfunction, Right - physiopathology</subject><ispartof>European heart journal cardiovascular imaging, 2012-08, Vol.13 (8), p.680-689</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-b7b232971a97de6cf11f3f989eccf107ab1411acdc7d4b744a0cda994bee043d3</citedby><cites>FETCH-LOGICAL-c395t-b7b232971a97de6cf11f3f989eccf107ab1411acdc7d4b744a0cda994bee043d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22307866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellavia, Diego</creatorcontrib><creatorcontrib>Pellikka, Patricia A</creatorcontrib><creatorcontrib>Dispenzieri, Angela</creatorcontrib><creatorcontrib>Scott, Christopher G</creatorcontrib><creatorcontrib>Al-Zahrani, Ghormallah B</creatorcontrib><creatorcontrib>Grogan, Martha</creatorcontrib><creatorcontrib>Pitrolo, Francesco</creatorcontrib><creatorcontrib>Oh, Jae K</creatorcontrib><creatorcontrib>Miller, Jr, Fletcher A</creatorcontrib><title>Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis of cardiac involvement and risk stratification in primary systematic (AL) amyloidosis: a 5-year cohort study</title><title>European heart journal cardiovascular imaging</title><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><description>To determine the role of assessing right ventricular (RV) function, using standard echocardiography and Doppler myocardial imaging (DMI), in the early diagnosis of cardiac amyloidosis and in the prediction of mortality.
Patients with primary systemic (AL) amyloidosis seen at our institution from 1 February 2004 through 31 October 2005 (N=249) were categorized by left ventricular thickness and E' velocity and compared with 38 age- and sex-matched controls. Standard echocardiographic and DMI examination were used to measure echocardiographic parameters of RV function: systolic tissue velocity, strain rate, and strain were determined for basal and middle RV free wall segments. Patients were followed up for the endpoint of mortality. RV tricuspid annular plane systolic excursion (TAPSE) and all DMI measurements were lower in patients with AL amyloidosis and normal echocardiography results (AL-normal-echo group) than controls. A bivariate model including strain of the basal segment of the RV free wall and TAPSE was the best for distinguishing AL-normal-echo patients from controls. Male sex [hazard ratio (HR), 2.2; P=0.005], brain natriuretic peptide levels (HR 1.4; P=0.003), troponin T levels (HR 1.6; P=0.01), pleural effusion (HR 3.6; P<0.001), E/A ratio (HR 1.3; P=0.006), RV systolic pressure (HR 1.02; P=0.01), and RV strain rate of the middle segment (HR 1.3; P=0.02) were independent predictors of death.
DMI measures of the RV can identify early impairment of cardiac function or stratify risk of death in patients with AL amyloidosis. Further studies with longer follow-up are warranted to confirm these results.</description><subject>Amyloidosis - diagnostic imaging</subject><subject>Amyloidosis - physiopathology</subject><subject>Biomarkers - analysis</subject><subject>Case-Control Studies</subject><subject>Echocardiography, Doppler</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Immunoglobulin Light-chain Amyloidosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>Risk Assessment</subject><subject>ROC Curve</subject><subject>Statistics, Nonparametric</subject><subject>Survival Analysis</subject><subject>Tricuspid Valve - diagnostic imaging</subject><subject>Tricuspid Valve - physiopathology</subject><subject>Ventricular Dysfunction, Right - diagnostic imaging</subject><subject>Ventricular Dysfunction, Right - physiopathology</subject><issn>2047-2404</issn><issn>2047-2412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1v3CAQxZ0qUROlufVczTGV1gnYrB33Fq36Ja3US3u2xoC9s8Hggr2q__uy3k04wAh-evOGlyQfOXvgrMof9W4v6XGvA2PVu-QmY6JMM8Gzy7eaievkLoQ9i2stCpHx98l1luWsfCqKm4tk4_oBPQVnwbXgqduNcNB29CQngx6Msx2NkyKLBsLokSxQjx3ZbgULFQZSgNYu-GDQaghzGJ0hCfqfnHwgZ1eRUCDRK0IJDbke_Yv2AVrnQaM3M8SXzrpA4WjklSR7cOag--hoUYhOXxYbI7Uk4x59R0eDj578vDTWfbyWcP-8_QzYz8aROqp-AYR1OsdeIN3O-THKTGr-kFy1aIK-O5-3yZ9vX39vfqTbX99_bp63qcyr9Zg2ZZPlWVVyrEqlC9ly3uZt9VRpGWtWYsMF5yiVLJVoSiGQSYVVJRqtmchVfpvcn3QH7_5OOox1T0Fqc_wvN4WasyymI4qCRXR1QqV3IXjd1ufxIlQfY6-X2OtT7BH_dFaeml6rN_g15Pw_ts-yKA</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Bellavia, Diego</creator><creator>Pellikka, Patricia A</creator><creator>Dispenzieri, Angela</creator><creator>Scott, Christopher G</creator><creator>Al-Zahrani, Ghormallah B</creator><creator>Grogan, Martha</creator><creator>Pitrolo, Francesco</creator><creator>Oh, Jae K</creator><creator>Miller, Jr, Fletcher A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis of cardiac involvement and risk stratification in primary systematic (AL) amyloidosis: a 5-year cohort study</title><author>Bellavia, Diego ; Pellikka, Patricia A ; Dispenzieri, Angela ; Scott, Christopher G ; Al-Zahrani, Ghormallah B ; Grogan, Martha ; Pitrolo, Francesco ; Oh, Jae K ; Miller, Jr, Fletcher A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-b7b232971a97de6cf11f3f989eccf107ab1411acdc7d4b744a0cda994bee043d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amyloidosis - diagnostic imaging</topic><topic>Amyloidosis - physiopathology</topic><topic>Biomarkers - analysis</topic><topic>Case-Control Studies</topic><topic>Echocardiography, Doppler</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Immunoglobulin Light-chain Amyloidosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>Risk Assessment</topic><topic>ROC Curve</topic><topic>Statistics, Nonparametric</topic><topic>Survival Analysis</topic><topic>Tricuspid Valve - diagnostic imaging</topic><topic>Tricuspid Valve - physiopathology</topic><topic>Ventricular Dysfunction, Right - diagnostic imaging</topic><topic>Ventricular Dysfunction, Right - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellavia, Diego</creatorcontrib><creatorcontrib>Pellikka, Patricia A</creatorcontrib><creatorcontrib>Dispenzieri, Angela</creatorcontrib><creatorcontrib>Scott, Christopher G</creatorcontrib><creatorcontrib>Al-Zahrani, Ghormallah B</creatorcontrib><creatorcontrib>Grogan, Martha</creatorcontrib><creatorcontrib>Pitrolo, Francesco</creatorcontrib><creatorcontrib>Oh, Jae K</creatorcontrib><creatorcontrib>Miller, Jr, Fletcher A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellavia, Diego</au><au>Pellikka, Patricia A</au><au>Dispenzieri, Angela</au><au>Scott, Christopher G</au><au>Al-Zahrani, Ghormallah B</au><au>Grogan, Martha</au><au>Pitrolo, Francesco</au><au>Oh, Jae K</au><au>Miller, Jr, Fletcher A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis of cardiac involvement and risk stratification in primary systematic (AL) amyloidosis: a 5-year cohort study</atitle><jtitle>European heart journal cardiovascular imaging</jtitle><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>13</volume><issue>8</issue><spage>680</spage><epage>689</epage><pages>680-689</pages><issn>2047-2404</issn><eissn>2047-2412</eissn><abstract>To determine the role of assessing right ventricular (RV) function, using standard echocardiography and Doppler myocardial imaging (DMI), in the early diagnosis of cardiac amyloidosis and in the prediction of mortality.
Patients with primary systemic (AL) amyloidosis seen at our institution from 1 February 2004 through 31 October 2005 (N=249) were categorized by left ventricular thickness and E' velocity and compared with 38 age- and sex-matched controls. Standard echocardiographic and DMI examination were used to measure echocardiographic parameters of RV function: systolic tissue velocity, strain rate, and strain were determined for basal and middle RV free wall segments. Patients were followed up for the endpoint of mortality. RV tricuspid annular plane systolic excursion (TAPSE) and all DMI measurements were lower in patients with AL amyloidosis and normal echocardiography results (AL-normal-echo group) than controls. A bivariate model including strain of the basal segment of the RV free wall and TAPSE was the best for distinguishing AL-normal-echo patients from controls. Male sex [hazard ratio (HR), 2.2; P=0.005], brain natriuretic peptide levels (HR 1.4; P=0.003), troponin T levels (HR 1.6; P=0.01), pleural effusion (HR 3.6; P<0.001), E/A ratio (HR 1.3; P=0.006), RV systolic pressure (HR 1.02; P=0.01), and RV strain rate of the middle segment (HR 1.3; P=0.02) were independent predictors of death.
DMI measures of the RV can identify early impairment of cardiac function or stratify risk of death in patients with AL amyloidosis. Further studies with longer follow-up are warranted to confirm these results.</abstract><cop>England</cop><pmid>22307866</pmid><doi>10.1093/ehjci/jes009</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Amyloidosis - diagnostic imaging Amyloidosis - physiopathology Biomarkers - analysis Case-Control Studies Echocardiography, Doppler Electrocardiography Female Humans Image Interpretation, Computer-Assisted Immunoglobulin Light-chain Amyloidosis Male Middle Aged Prospective Studies Reproducibility of Results Risk Assessment ROC Curve Statistics, Nonparametric Survival Analysis Tricuspid Valve - diagnostic imaging Tricuspid Valve - physiopathology Ventricular Dysfunction, Right - diagnostic imaging Ventricular Dysfunction, Right - physiopathology |
| title | Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis of cardiac involvement and risk stratification in primary systematic (AL) amyloidosis: a 5-year cohort study |
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