Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM®)
Summary We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group recei...
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| Veröffentlicht in: | Anaesthesia 2012-08, Vol.67 (8), p.862-869 |
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| creator | Na, H. S. Chung, Y. H. Hwang, J. W. Do, S. H. |
| description | Summary
We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group received magnesium sulphate (50 mg.kg−1 followed by continuous infusion of 15 mg.kg−1.h−1), whereas the control group received the same volume of isotonic saline according to the same methods. Mean (SD) postoperative serum magnesium levels were 1.58 (0.17) mmol.l−1 in the magnesium group compared with 0.98 (0.06) mmol.l−1 in the control group (p |
| doi_str_mv | 10.1111/j.1365-2044.2012.07149.x |
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We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group received magnesium sulphate (50 mg.kg−1 followed by continuous infusion of 15 mg.kg−1.h−1), whereas the control group received the same volume of isotonic saline according to the same methods. Mean (SD) postoperative serum magnesium levels were 1.58 (0.17) mmol.l−1 in the magnesium group compared with 0.98 (0.06) mmol.l−1 in the control group (p < 0.001). Postoperative clotting time, clot formation time, α‐angle and maximum clot firmness of INTEM, and clot formation time, α‐angle, and maximum clot firmness of EXTEM were significantly different between the two groups (p < 0.05). Intra‐operative infusion of magnesium sulphate seems to attenuate postoperative hypercoagulability by maintaining magnesium levels at the upper limit of the normal range.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.2012.07149.x</identifier><identifier>PMID: 22519866</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Coagulation - drug effects ; Coagulation ; Double-Blind Method ; Gynecology ; Humans ; Magnesium ; Magnesium Sulfate - pharmacology ; Medical sciences ; Postoperative Complications - prevention & control ; Postoperative period ; Surgery ; Thrombelastography - methods ; Thrombophilia - prevention & control</subject><ispartof>Anaesthesia, 2012-08, Vol.67 (8), p.862-869</ispartof><rights>Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland</rights><rights>2015 INIST-CNRS</rights><rights>Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4789-51bbe12dc1e7cb254c90875ed34e9c25b8d66b2cf32e00e5abf58c523aa0e9043</citedby><cites>FETCH-LOGICAL-c4789-51bbe12dc1e7cb254c90875ed34e9c25b8d66b2cf32e00e5abf58c523aa0e9043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.2012.07149.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.2012.07149.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27926,27927,45576,45577,46411,46835</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26137442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22519866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Na, H. S.</creatorcontrib><creatorcontrib>Chung, Y. H.</creatorcontrib><creatorcontrib>Hwang, J. W.</creatorcontrib><creatorcontrib>Do, S. H.</creatorcontrib><title>Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM®)</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group received magnesium sulphate (50 mg.kg−1 followed by continuous infusion of 15 mg.kg−1.h−1), whereas the control group received the same volume of isotonic saline according to the same methods. Mean (SD) postoperative serum magnesium levels were 1.58 (0.17) mmol.l−1 in the magnesium group compared with 0.98 (0.06) mmol.l−1 in the control group (p < 0.001). Postoperative clotting time, clot formation time, α‐angle and maximum clot firmness of INTEM, and clot formation time, α‐angle, and maximum clot firmness of EXTEM were significantly different between the two groups (p < 0.05). Intra‐operative infusion of magnesium sulphate seems to attenuate postoperative hypercoagulability by maintaining magnesium levels at the upper limit of the normal range.</description><subject>Adult</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation - drug effects</subject><subject>Coagulation</subject><subject>Double-Blind Method</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Magnesium</subject><subject>Magnesium Sulfate - pharmacology</subject><subject>Medical sciences</subject><subject>Postoperative Complications - prevention & control</subject><subject>Postoperative period</subject><subject>Surgery</subject><subject>Thrombelastography - methods</subject><subject>Thrombophilia - prevention & control</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdFqFDEUhoNY7Fp9BQmIUMEZk0wyk9wIS1lroVqQeh0ymTPtLJnJmMxo96V8CJ-sme5awStzk0Py_eck_48QpiSnab3f5rQoRcYI5zkjlOWkolzld0_Q6vHiKVoRQoqMcaKO0fMYtySRkspn6JgxQZUsyxXym7YFO0XsW9ybmwFiN_c4zm68NRNgP-DRx8mPEMzU_QBsvbmZXar98A73YOIcoMH1Dgc_PZwah6fb4PvagzNJ2cMUdvj069X15vPvX29foKPWuAgvD_sJ-vZxc332Kbu8Or84W19mlldSZYLWNVDWWAqVrZngVhFZCWgKDsoyUcumLGtm24IBISBM3QppBSuMIaAIL07Q6b7vGPz3GeKk-y5acM4M4OeoKWE8TSJKJfT1P-jWzyF9ZE_RZJYUiZJ7ygYfY4BWj6HrTdglSC-h6K1evNeL93oJRT-Eou-S9NVhwFz30DwK_6SQgDcHwERrXBvMYLv4lytpUXHOEvdhz_3sHOz--wF6_WW9WcriHrqOqYc</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Na, H. S.</creator><creator>Chung, Y. H.</creator><creator>Hwang, J. W.</creator><creator>Do, S. H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM®)</title><author>Na, H. S. ; Chung, Y. H. ; Hwang, J. W. ; Do, S. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4789-51bbe12dc1e7cb254c90875ed34e9c25b8d66b2cf32e00e5abf58c523aa0e9043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation - drug effects</topic><topic>Coagulation</topic><topic>Double-Blind Method</topic><topic>Gynecology</topic><topic>Humans</topic><topic>Magnesium</topic><topic>Magnesium Sulfate - pharmacology</topic><topic>Medical sciences</topic><topic>Postoperative Complications - prevention & control</topic><topic>Postoperative period</topic><topic>Surgery</topic><topic>Thrombelastography - methods</topic><topic>Thrombophilia - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Na, H. S.</creatorcontrib><creatorcontrib>Chung, Y. H.</creatorcontrib><creatorcontrib>Hwang, J. W.</creatorcontrib><creatorcontrib>Do, S. H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Na, H. S.</au><au>Chung, Y. H.</au><au>Hwang, J. W.</au><au>Do, S. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM®)</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2012-08</date><risdate>2012</risdate><volume>67</volume><issue>8</issue><spage>862</spage><epage>869</epage><pages>862-869</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group received magnesium sulphate (50 mg.kg−1 followed by continuous infusion of 15 mg.kg−1.h−1), whereas the control group received the same volume of isotonic saline according to the same methods. Mean (SD) postoperative serum magnesium levels were 1.58 (0.17) mmol.l−1 in the magnesium group compared with 0.98 (0.06) mmol.l−1 in the control group (p < 0.001). Postoperative clotting time, clot formation time, α‐angle and maximum clot firmness of INTEM, and clot formation time, α‐angle, and maximum clot firmness of EXTEM were significantly different between the two groups (p < 0.05). Intra‐operative infusion of magnesium sulphate seems to attenuate postoperative hypercoagulability by maintaining magnesium levels at the upper limit of the normal range.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22519866</pmid><doi>10.1111/j.1365-2044.2012.07149.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Coagulation - drug effects Coagulation Double-Blind Method Gynecology Humans Magnesium Magnesium Sulfate - pharmacology Medical sciences Postoperative Complications - prevention & control Postoperative period Surgery Thrombelastography - methods Thrombophilia - prevention & control |
| title | Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM®) |
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