Isoenzyme expression changes in response to high temperature determine the metabolic regulation of increased glycolytic flux in yeast

Abstract Qualitative phenotypic changes are the integrated result of quantitative changes at multiple regulatory levels. To explain the temperature-induced increase of glycolytic flux in fermenting cultures of Saccharomyces cerevisiae, we quantified the contributions of changes in activity at many r...

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Veröffentlicht in:	FEMS yeast research 2012-08, Vol.12 (5), p.571-581
Hauptverfasser:	Postmus, Jarne, Aardema, Ronald, de Koning, Leo J., de Koster, Chris G., Brul, Stanley, Smits, Gertien J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive response Enzymatic activity Enzyme kinetics gene expression Gene Expression Regulation, Fungal Glycolysis High temperature Isoenzymes Isoenzymes - chemistry Isoenzymes - metabolism Mass Spectrometry metabolic flux Metabolism Post-translation quantitative physiology Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - radiation effects Temperature temperature control Temperature effects
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