Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance

Pregabalin increased the incidence of hemangiosarcomas in carcinogenicity studies of 2-year mice but was not tumorigenic in rats. Serum bicarbonate increased within 24 h of pregabalin administration in mice and rats. Rats compensated appropriately, but mice developed metabolic alkalosis and increase...

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Veröffentlicht in:	Toxicological sciences 2012-07, Vol.128 (1), p.57-71
Hauptverfasser:	Criswell, Kay A, Cook, Jon C, Wojcinski, Zbigniew, Pegg, David, Herman, James, Wesche, David, Giddings, John, Brady, Joseph T, Anderson, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Dose-Response Relationship, Drug gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - toxicity Hemangiosarcoma - chemically induced Hemangiosarcoma - pathology Humans Macrophage Activation Mice Pregabalin
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