Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve
Peripheral nerve injuries lead to a variety of pathological conditions, including paresis or paralysis when the injury involves motor axons. We have been studying ways to enhance the regeneration of peripheral nerves using daily electrical stimulation (ES) following a facial nerve crush injury. In o...
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| Veröffentlicht in: | Journal of rehabilitation research and development 2012-01, Vol.49 (3), p.451-458 |
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| container_title | Journal of rehabilitation research and development |
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| creator | Foecking, Eileen M Fargo, Keith N Coughlin, Lisa M Kim, James T Marzo, Sam J Jones, Kathryn J |
| description | Peripheral nerve injuries lead to a variety of pathological conditions, including paresis or paralysis when the injury involves motor axons. We have been studying ways to enhance the regeneration of peripheral nerves using daily electrical stimulation (ES) following a facial nerve crush injury. In our previous studies, ES was not initiated until 24 h after injury. The current experiment tested whether ES administered immediately following the crush injury would further decrease the time for complete recovery from facial paralysis. Rats received a unilateral facial nerve crush injury and an electrode was positioned on the nerve proximal to the crush site. Animals received daily 30 min sessions of ES for 1 d (day of injury only), 2 d, 4 d, 7 d, or daily until complete functional recovery. Untreated animals received no ES. Animals were observed daily for the return of facial function. Our findings demonstrated that one session of ES was as effective as daily stimulation at enhancing the recovery of most functional parameters. Therefore, the use of a single 30 min session of ES as a possible treatment strategy should be studied in human patients with paralysis as a result of acute nerve injuries. |
| doi_str_mv | 10.1682/JRRD.2011.03.0033 |
| format | Article |
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We have been studying ways to enhance the regeneration of peripheral nerves using daily electrical stimulation (ES) following a facial nerve crush injury. In our previous studies, ES was not initiated until 24 h after injury. The current experiment tested whether ES administered immediately following the crush injury would further decrease the time for complete recovery from facial paralysis. Rats received a unilateral facial nerve crush injury and an electrode was positioned on the nerve proximal to the crush site. Animals received daily 30 min sessions of ES for 1 d (day of injury only), 2 d, 4 d, 7 d, or daily until complete functional recovery. Untreated animals received no ES. Animals were observed daily for the return of facial function. Our findings demonstrated that one session of ES was as effective as daily stimulation at enhancing the recovery of most functional parameters. Therefore, the use of a single 30 min session of ES as a possible treatment strategy should be studied in human patients with paralysis as a result of acute nerve injuries.</description><identifier>ISSN: 0748-7711</identifier><identifier>EISSN: 1938-1352</identifier><identifier>DOI: 10.1682/JRRD.2011.03.0033</identifier><identifier>PMID: 22773203</identifier><identifier>CODEN: JRRDDB</identifier><language>eng</language><publisher>United States: Department of Veterans Affairs</publisher><subject>Animals ; Diseases ; Electric Stimulation - methods ; Electric Stimulation Therapy ; Electrodes ; Facial nerve ; Facial Nerve - physiology ; Facial Nerve Injuries - physiopathology ; Facial Nerve Injuries - therapy ; Facial Paralysis - physiopathology ; Facial Paralysis - therapy ; Health aspects ; Health care ; Injuries ; Medical research ; Nerve Regeneration - physiology ; Neural stimulation ; Rats ; Rats, Sprague-Dawley ; Recovery of Function ; Rodents ; Surgery ; Vibrissae - innervation</subject><ispartof>Journal of rehabilitation research and development, 2012-01, Vol.49 (3), p.451-458</ispartof><rights>COPYRIGHT 2012 Department of Veterans Affairs</rights><rights>Copyright Superintendent of Documents 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-63a3ec1c9561c4eed62b940e3a2b3c6f93d9d0b0bd9268248cb76b2038f94fac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22773203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foecking, Eileen M</creatorcontrib><creatorcontrib>Fargo, Keith N</creatorcontrib><creatorcontrib>Coughlin, Lisa M</creatorcontrib><creatorcontrib>Kim, James T</creatorcontrib><creatorcontrib>Marzo, Sam J</creatorcontrib><creatorcontrib>Jones, Kathryn J</creatorcontrib><title>Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve</title><title>Journal of rehabilitation research and development</title><addtitle>J Rehabil Res Dev</addtitle><description>Peripheral nerve injuries lead to a variety of pathological conditions, including paresis or paralysis when the injury involves motor axons. We have been studying ways to enhance the regeneration of peripheral nerves using daily electrical stimulation (ES) following a facial nerve crush injury. In our previous studies, ES was not initiated until 24 h after injury. The current experiment tested whether ES administered immediately following the crush injury would further decrease the time for complete recovery from facial paralysis. Rats received a unilateral facial nerve crush injury and an electrode was positioned on the nerve proximal to the crush site. Animals received daily 30 min sessions of ES for 1 d (day of injury only), 2 d, 4 d, 7 d, or daily until complete functional recovery. Untreated animals received no ES. Animals were observed daily for the return of facial function. Our findings demonstrated that one session of ES was as effective as daily stimulation at enhancing the recovery of most functional parameters. Therefore, the use of a single 30 min session of ES as a possible treatment strategy should be studied in human patients with paralysis as a result of acute nerve injuries.</description><subject>Animals</subject><subject>Diseases</subject><subject>Electric Stimulation - methods</subject><subject>Electric Stimulation Therapy</subject><subject>Electrodes</subject><subject>Facial nerve</subject><subject>Facial Nerve - physiology</subject><subject>Facial Nerve Injuries - physiopathology</subject><subject>Facial Nerve Injuries - therapy</subject><subject>Facial Paralysis - physiopathology</subject><subject>Facial Paralysis - therapy</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Injuries</subject><subject>Medical research</subject><subject>Nerve Regeneration - physiology</subject><subject>Neural stimulation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recovery of Function</subject><subject>Rodents</subject><subject>Surgery</subject><subject>Vibrissae - 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We have been studying ways to enhance the regeneration of peripheral nerves using daily electrical stimulation (ES) following a facial nerve crush injury. In our previous studies, ES was not initiated until 24 h after injury. The current experiment tested whether ES administered immediately following the crush injury would further decrease the time for complete recovery from facial paralysis. Rats received a unilateral facial nerve crush injury and an electrode was positioned on the nerve proximal to the crush site. Animals received daily 30 min sessions of ES for 1 d (day of injury only), 2 d, 4 d, 7 d, or daily until complete functional recovery. Untreated animals received no ES. Animals were observed daily for the return of facial function. Our findings demonstrated that one session of ES was as effective as daily stimulation at enhancing the recovery of most functional parameters. Therefore, the use of a single 30 min session of ES as a possible treatment strategy should be studied in human patients with paralysis as a result of acute nerve injuries.</abstract><cop>United States</cop><pub>Department of Veterans Affairs</pub><pmid>22773203</pmid><doi>10.1682/JRRD.2011.03.0033</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of rehabilitation research and development, 2012-01, Vol.49 (3), p.451-458 |
| issn | 0748-7711 1938-1352 |
| language | eng |
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| source | U.S. Government Documents; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Diseases Electric Stimulation - methods Electric Stimulation Therapy Electrodes Facial nerve Facial Nerve - physiology Facial Nerve Injuries - physiopathology Facial Nerve Injuries - therapy Facial Paralysis - physiopathology Facial Paralysis - therapy Health aspects Health care Injuries Medical research Nerve Regeneration - physiology Neural stimulation Rats Rats, Sprague-Dawley Recovery of Function Rodents Surgery Vibrissae - innervation |
| title | Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve |
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